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Correlation between bilateral GFR in patients with localized renal cancer after partial nephrectomy

  • Urology - Original Paper
  • Published:
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Abstract

Objective

To explore the relationship between the residual glomerular filtration rate (GFR) on the operated side and the GFR on the contralateral side following partial nephrectomy (PN) in patients with localized renal cell carcinoma (RCC).

Materials and methods

Following institutional review board approval, we conducted a retrospective analysis of clinical records from May 2018 to July 2023, involving 118 patients who underwent partial nephrectomy for unilateral localized kidney tumors (T1–T2). Glomerular filtration rate data were assessed using single photon emission computed tomography (SPECT)/computed tomography imaging [using 9mTc-DTPA (diethylenetriaminepentaacetic acid) renal dynamic imaging]. The independent determinants of postoperative renal function or renal function change were determined using linear regression analysis. In addition, the patient's demographic, clinical, and nephrometry characteristics were collected.

Results

A total of 58 patients were finally enrolled. The preoperative and postoperative GFR of bilateral kidneys showed a significant positive correlation. Postoperative GFR of the operated kidney was the independent predictor of GFR of contralateral kidney (p = 0.001). Tumor diameter (p = 0.036), age (p = 0.005), and postoperative GFR of the contralateral kidney (p = 0.001) were all independent predictors of postoperative GFR of the operated kidney. ΔGFR1 was the independent predictor of ΔGFR2. Results showed that a more pronounced postoperative decline in GFR on the operated side corresponded to a weaker compensatory capacity of the contralateral-side kidney.

Conclusions

During the course of the surgical procedure, the active endeavor to safeguard the renal function of the operated kidney side holds paramount importance, which yields positive outcomes for postoperative kidney function on the contralateral side, consequently contributing to the overall preservation of renal function.

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Data availability

All relevant data during this study are within the paper.

Abbreviations

PN:

Partial nephrectomy

RN:

Radical nephrectomy

GFR:

Glomerular filtration rate

RCC:

Renal cell carcinoma

BMI:

Body mass index

RhGH:

Recombinant human growth hormone

CKD:

Chronic kidney disease

ΔGFR1:

Change in the glomerular filtration rate on the operated side

ΔGFR2:

Change in the glomerular filtration rate on the contralateral side

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Funding

This study was supported by the Tianjin Health Science and Technology Project (ZC20130) and the Tianjin Science and Technology Planning Project (21JCYBJC00170).

Author information

Authors and Affiliations

  1. Urology, The Third Central Clinical College of Tianjin Medical University, Tianjin, 300170, China

    Wu Wensong

  2. Urology, The Third Central Hospital of Tianjin, 83 Jintang Road, Hedong District, Tianjin, 300170, China

    Chang Fan, Zhang Jianghui, Tang Shuai, Lv Zheng, Liu Xuehui & Chen Fangmin

  3. Nuclear Medicine Department, The Third Central Hospital of Tianjin, 83 Jintang Road, Hedong District, Tianjin, 300170, China

    Liu Xuehui

  4. The Third Central Hospital affiliated to Nankai University, Jintang Road, Hedong District, Tianjin, 300170, China

    Chang Fan, Zhang Jianghui, Tang Shuai, Lv Zheng & Chen Fangmin

Authors
  1. Wu Wensong
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  2. Chang Fan
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  3. Zhang Jianghui
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  4. Tang Shuai
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  5. Lv Zheng
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  6. Liu Xuehui
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  7. Chen Fangmin
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Contributions

The provided concept and study objective were created by WW. CF and WW created the study and wrote the article. ZJ collected the information. CF, WW, TS, LZ and LX carried out the analysis. The results of this study were overseen by CF. The paper has been read and approved by all authors.

Corresponding author

Correspondence to Chen Fangmin.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Not applicable.

Ethics approval and consent to participate

This study was approved by the Ethics Committee of the Third Central Hospital of Tianjin (IRB2023-010-01) and strictly adhered to the tenets of the Declaration of Helsinki. In addition, all patients signed an informed consent form before the operation.

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Wensong, W., Fan, C., Jianghui, Z. et al. Correlation between bilateral GFR in patients with localized renal cancer after partial nephrectomy. Int Urol Nephrol 56, 1617–1625 (2024). https://doi.org/10.1007/s11255-023-03901-w

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  • DOI: https://doi.org/10.1007/s11255-023-03901-w

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