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Management of spinal cord injury patients with neurogenic lower urinary tract dysfunction using minimally invasive and surgical therapies in Taiwan

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An Urology – Letter to the Editor to this article was published on 13 April 2024

Abstract

The main problems of neurogenic lower urinary tract dysfunction (NLUTD) in patients with spinal cord injury (SCI) consist of impaired urine storage, impaired bladder emptying, or both. The priorities in the management of SCI–NLUTD should be preservation of renal function, followed by freedom from urinary tract infections and improvement of quality of life. Management of NLUTD in patients with SCI must be based on urodynamic findings rather than clinical evaluations. In the hospital without urodynamic equipment, careful measurement of intravesical pressure and safety functional bladder capacity in conjunction with clinical assessment are also feasible. Identification of high-risk patients is important for preventing urological complications in patients with chronic SCI. The management of NLUTD should start with conservative bladder management and medical treatment. Patients with SCI should be regularly followed up, and any NLUTDs and urological complications should be adequately treated. When surgical intervention is necessary, less invasive and reversible procedures should be considered first, and any unnecessary surgery should be avoided. This article reports the current evidence and expert opinions on the patient-centered bladder management of NLUTD in chronic SCI patients in Taiwan. To avoid renal function deterioration and urological complications, annual active surveillance of bladder and renal function is mandatory, especially for high-risk SCI patients.

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References

  1. Groen J, Pannek J, Castro Diaz D, Del Popolo G, Gross T, Hamid R, Karsenty G, Kessler TM, Schneider M, 't Hoen L, Blok B (2016) Summary of European Association of Urology (EAU) Guidelines on Neuro-Urology. Eur Urol 69:324-333

  2. Chen YJ, Lo SH, Meng E, Shen JD, Eric Chou CL, Chen SF, Lee MH, Hsu CY, Ong HL, Chen JT, Chen SL, Tsai YA, Lin CC, Wu SY, Chiu B, Kuo HC, Taiwan Continence Society Spinal Cord Injury Study Group (2023) Clinical guidelines of patient-centered bladder management of neurogenic lower urinary tract dysfunction due to chronic spinal cord injury–Part 1: Pathophysiology, treatment strategy and priority. Urol Sci 34:3–9

    Google Scholar 

  3. Chen SF, Kuo HC (2022) Interventional management and surgery of neurogenic lower urinary tract dysfunction in patients with chronic spinal cord injury: a urologist’s perspective. Low Urin Tract Symp 14:132–139

    Article  Google Scholar 

  4. Chang TL, Kuo HC (2023) The videourodynamic characteristics of patients with chronic spinal cord injury with different injury levels and bladder conditions. Urol Sci 34:46–52

    Google Scholar 

  5. Ong HL, Chiang IN, Hsu LN, Chin CW, Shao IH, Jang MY, Juan YS, Wang CC, Kuo HC, Taiwan Continence Society Spinal Cord Injury Study Group (2023) Conservative bladder management and medical treatment in chronic spinal cord injury patients. J Clin Med 12:2021

    Article  PubMed  PubMed Central  Google Scholar 

  6. Wu SY, Jhang JF, Liu HH, Chen JT, Li JR, Chiu B, Chen SL, Kuo HC (2023) Long-term surveillance and management of urological complications in chronic spinal cord-injured patients. J Clin Med 11:7307

    Article  Google Scholar 

  7. Lin YH, Fan YH, Wu CT, Shen YC, Hu JC, Huang SW, Chow PM, Chang PC, Liao CH, Chen YC, Victor C. Lin, Hsu CC, Chang SJ, Wang CC, Lin WY, Lin CC, Jiang YH, Kuo HC, Taiwan Continence Society Spinal Cord Injury Study Group (2023) Clinical guidelines of patient-centered bladder management of neurogenic lower urinary tract dysfunction due to chronic spinal cord injury – Part 3: Surgical treatment in chronic spinal cord injured patients. Urol Sci 34:109-116

  8. McGuire EJ, Cespedes RD, O’Connell HE (1996) Leak-point pressures. Urol Clin North Am 23:253–262

    Article  CAS  PubMed  Google Scholar 

  9. Stöhrer M, Goepel M, Kondo A, Kramer G, Madersbacher H, Millard R, Rossier A, Wyndaele JJ (1999) The standardization of terminology in neurogenic lower urinary tract dysfunction: with suggestions for diagnostic procedures. International Continence Society Standardization Committee. Neurourol Urodyn 18:139–158

    Article  PubMed  Google Scholar 

  10. Madersbacher S, Pycha A, Klingler CH, Mian C, Djavan B, Stulnig T, Marberger M (1999) Interrelationships of bladder compliance with age, detrusor instability, and obstruction in elderly men with lower urinary tract symptoms. Neurourol Urodyn 18:3–15

    Article  CAS  PubMed  Google Scholar 

  11. Weld KJ, Wall BM, Mangold TA, Steere EL, Dmochowski RR (2000) Influences on renal function in chronic spinal cord injured patients. J Urol 164:1490–1493

    Article  CAS  PubMed  Google Scholar 

  12. Mitsui T, Minami K, Furuno T, Morita H, Koyanagi T (2000) Is suprapubic cystostomy an optimal urinary management in high quadriplegics?. A comparative study of suprapubic cystostomy and clean intermittent catheterization. Eur Urol 38:434–438

    Article  CAS  PubMed  Google Scholar 

  13. Weld KJ, Dmochowski RR (2000) Effect of bladder management on urological complications in spinal cord injured patients. J Urol 163:768–772

    Article  CAS  PubMed  Google Scholar 

  14. Cameron AP, Wallner LP, Tate DG, Sarma AV, Rodriguez GM, Clemens JQ (2010) Bladder management after spinal cord injury in the United States 1972 to 2005. J Urol 184:213–217

    Article  PubMed  Google Scholar 

  15. Chen SF, Jiang YH, Jhang JF, Lee CL, Kuo HC (2014) Bladder management and urological complications in patients with chronic SCI in Taiwan. Tzu Chi Med J 26:25–28

    Article  Google Scholar 

  16. Ginsberg DA, Boone TB, Cameron AP, Gousse A, Kaufman MR, Keays E, Kennelly MJ, Lemack GE, Rovner ES, Souter LH, Yang CC, Kraus SR (2021) The AUA/SUFU guideline on adult neurogenic lower urinary tract dysfunction: treatment and follow-up. J Urol 206:1106–1113

    Article  PubMed  Google Scholar 

  17. Zhang D, Sun F, Yao H, Bao X, Wang D, Cui Y, Wu J (2021) The efficacy and safety of mirabegron for the treatment of neurogenic lower urinary tract dysfunction: a systematic review and meta-analysis. Front Pharmacol 12:756582

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Reitz A, Haferkamp A, Kyburz T, Knapp PA, Wefer B, Schurch B (2004) The effect of tamsulosin on the resting tone and the contractile behaviour of the female urethra: a functional urodynamic study in healthy women. Eur Urol 46:235–240

    Article  CAS  PubMed  Google Scholar 

  19. Diokno AC, Koppenhoefer R (1976) Bethanechol chloride in neurogenic bladder dysfunction. Urology 8:455–458

    Article  CAS  PubMed  Google Scholar 

  20. Light JK, Scott FB (1982) Bethanechol chloride and the traumatic cord bladder. J Urol 128:85–87

    Article  CAS  PubMed  Google Scholar 

  21. Mangera A, Apostolidis A, Andersson KE, Dasgupta P, Giannantoni A, Roehrborn C, Novara G, Chapple C (2014) An updated systematic review and statistical comparison of standardised mean outcomes for the use of botulinum toxin in the management of lower urinary tract disorders. Eur Urol 65:981–990

    Article  CAS  PubMed  Google Scholar 

  22. Dykstra DD, Sidi AA (1990) Treatment of detrusor-sphincter dyssynergia with botulinum a toxin: a double-blind study. Arch Phys Med Rehabil 71:24–26

    CAS  PubMed  Google Scholar 

  23. Schurch B, Hauri D, Rodic B, Curt A, Meyer M, Rossier AB (1996) Botulinum-A toxin as a treatment of detrusor-sphincter dyssynergia: a prospective study in 24 spinal cord injury patients. J Urol 2:519–533

    Google Scholar 

  24. Kuo HC (2003) Botulinum A toxin urethral injection for the treatment of lower urinary tract dysfunction. J Urol 170:1908–1912

    Article  CAS  PubMed  Google Scholar 

  25. Kuo HC, Liu HT, Chuang YC, Birder LA, Chancellor MB (2014) Pilot study of liposome-encapsulated onabotulinumtoxina for patients with overactive bladder: a single-center study. Eur Urol 65:1117–1124

    Article  CAS  PubMed  Google Scholar 

  26. Chen SF, Kuo HC (2021) Will repeated botulinum toxin A improve detrusor overactivity and bladder compliance in patients with chronic spinal cord injury? Tzu Chi Med J 33:101–107

    Article  PubMed  Google Scholar 

  27. Schurch B, de Sèze M, Denys P, Chartier-Kastler E, Haab F, Everaert K, Plante P, Perrouin-Verbe B, Kumar C, Fraczek S, Brin MF, Botox Detrusor Hyperreflexia Study Team (2005) Botulinum toxin type a is a safe and effective treatment for neurogenic urinary incontinence: results of a single treatment, randomized, placebo controlled 6-month study. J Urol 174:196–200

    Article  CAS  PubMed  Google Scholar 

  28. Kuo HC, Liu SH (2011) Effect of repeated detrusor onabotulinumtoxinA injections on bladder and renal function in patients with chronic spinal cord injuries. Neurourol Urodyn 30:1541–1545

    Article  PubMed  Google Scholar 

  29. Chen YC, Kuo HC (2014) The therapeutic effects of repeated detrusor injections between 200 or 300 units of onabotulinumtoxinA in chronic spinal cord injured patients. Neurourol Urodyn 33:129–134

    Article  CAS  PubMed  Google Scholar 

  30. Chen CY, Liao CH, Kuo HC (2011) Therapeutic effects of detrusor botulinum toxin a injection on neurogenic detrusor overactivity in patients with different levels of spinal cord injury and types of detrusor sphincter dyssynergia. Spinal Cord 49:659–664

    Article  PubMed  Google Scholar 

  31. Kuo HC (2006) Therapeutic effects of suburothelial injection of botulinum a toxin for neurogenic detrusor overactivity due to chronic cerebrovascular accident and spinal cord lesions. Urology 67:232–236

    Article  PubMed  Google Scholar 

  32. Grosse J, Kramer G, Stöhrer M (2005) Success of repeat detrusor injections of botulinum a toxin in patients with severe neurogenic detrusor overactivity and incontinence. Eur Urol 47:653–659

    Article  CAS  PubMed  Google Scholar 

  33. Kuo HC (2008) Therapeutic satisfaction and dissatisfaction in patients with spinal cord lesions and detrusor sphincter dyssynergia who received detrusor botulinum toxin a injection. Urology 72:1056–1060

    Article  PubMed  Google Scholar 

  34. Chen SF, Kuo HC (2015) Therapeutic outcome and patient adherence to repeated onabotulinumtoxinA detrusor injections in chronic spinal cord-injured patients and neurogenic detrusor overactivity. J Formos Med Assoc 114:583–589

    Article  CAS  PubMed  Google Scholar 

  35. Ginsberg DA, Drake MJ, Kaufmann A, Radomski S, Gousse AE, Chermansky CJ, Magyar A, Nicandro JP, Nitti VW, 191622-096 Investigators (2017) Long-term treatment with onabotulinumtoxinA results in consistent, durable improvements in health related quality of life in patients with overactive bladder. J Urol 198:897–904

    Article  CAS  PubMed  Google Scholar 

  36. Chen PY, Cheng JH, Wu ZS, Chuang YC (2022) New Frontiers of extracorporeal shock wave medicine in urology from bench to clinical studies. Biomedicines 10:675

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Smith CP, Nishiguchi J, O’Leary M, Yoshimura N, Chancellor MB (2005) Single-institution experience in 110 patients with botulinum toxin A injection into bladder or urethra. Urology 65:37–41

    Article  PubMed  Google Scholar 

  38. Phelan MW, Franks M, Somogyi GT, Yokoyama T, Fraser MO, Lavelle JP, Yoshimura N, Chancellor MB (2001) Botulinum toxin urethral sphincter injection to restore bladder emptying in men and women with voiding dysfunction. J Urol 165:1107–1110

    Article  CAS  PubMed  Google Scholar 

  39. Kuo HC (2013) Therapeutic outcome and quality of life between urethral and detrusor botulinum toxin treatment for patients with spinal cord lesions and detrusor sphincter dyssynergia. Int J Clin Pract 67:1044–1049

    Article  CAS  PubMed  Google Scholar 

  40. Elkelini MS, Bagli DJ, Fehlings M, Hassouna M (2012) Effects of intravesical onabotulinumtoxinA on bladder dysfunction and autonomic dysreflexia after spinal cord injury: role of nerve growth factor. BJU Int 109:402–407

    Article  CAS  PubMed  Google Scholar 

  41. Fougere RJ, Currie KD, Nigro MK, Stothers L, Rapoport D, Krassioukov AV (2016) Reduction in bladder-related autonomic dysreflexia after onabotulinumtoxinA treatment in spinal cord injury. J Neurotrauma 33:1651–1657

    Article  PubMed  PubMed Central  Google Scholar 

  42. Tow AM, Toh KL, Chan SP, Consigliere D (2007) Botulinum toxin type A for refractory neurogenic detrusor overactivity in spinal cord injured patients in Singapore. Ann Acad Med Singap 36:11–17

    Article  PubMed  Google Scholar 

  43. Cruz F, Herschorn S, Aliotta P, Brin M, Thompson C, Lam W, Daniell G, Heesakkers J, Haag-Molkenteller C (2011) Efficacy and safety of onabotulinumtoxinA in patients with urinary incontinence due to neurogenic detrusor overactivity: a randomised, double-blind, placebo-controlled trial. Eur Urol 60:742–750

    Article  CAS  PubMed  Google Scholar 

  44. Jaggi A, Drake M, Siddiqui E, Fatoye F (2018) A comparison of the treatment recommendations for neurogenic lower urinary tract dysfunction in the national institute for health and care excellence, European association of urology and international consultations on incontinence guidelines. Neurourol Urodyn 37:2273–2280

    Article  PubMed  Google Scholar 

  45. Kao YL, Chen JT, Chen SL, Shao IH, Wang CC, Chiang IN, Hsu YC, Lee KH, Lee WC, Yeh TC, Kuo YC, Chiang BJ, Liao CH, Chen PC, Meng E, Lee YC, Kuo HC, Taiwan Continence Society Spinal Cord Injury Study Group (2023) Clinical guidelines of patient-centered bladder management of neurogenic lower urinary tract dysfunction due to chronic spinal cord injury — Part 2: Conservative and minimally invasive treatment. Urol Sci 34:10–17

    Google Scholar 

  46. Wu SY, Kuo HC (2018) A real-world experience with augmentation enterocystoplasty-High patient satisfaction with high complication rates. Neurourol Urodyn 37:744–750

    Article  PubMed  Google Scholar 

  47. Perkash I (1978) Detrusor-sphincter dyssynergia and dyssynergic responses: recognition and rationale for early modified transurethral sphincterotomy in complete spinal cord injury lesions. J Urol 120:469–474

    Article  CAS  PubMed  Google Scholar 

  48. Pan D, Troy A, Rogerson J, Bolton D, Brown D, Lawrentschuk N (2009) Long-term outcomes of external sphincterotomy in a spinal injured population. J Urol 181:705–709

    Article  PubMed  Google Scholar 

  49. Takahashi R, Kimoto Y, Eto M (2018) Long-term urodynamic follow-up after external sphincterotomy in patients with spinal cord injury. Neurourol Urodyn 37:2625–2631

    Article  PubMed  Google Scholar 

  50. Ke QS, Kuo HC (2010) Transurethral incision of the bladder neck to treat bladder neck dysfunction and voiding dysfunction in patients with high-level spinal cord injuries. Neurourol Urodyn 29:748–752

    Article  PubMed  Google Scholar 

  51. Vainrib M, Reyblat P, Ginsberg DA (2014) Long-term efficacy of repeat incisions of bladder neck/external sphincter in patients with spinal cord injury. Urology 84:940–945

    Article  PubMed  Google Scholar 

  52. Chen SF, Jhang JF, Jiang YH, Kuo HC (2022) Treatment outcomes of detrusor underactivity in women based on clinical and videourodynamic characteristics. Int Urol Nephrol 54:1215–1223

    Article  PubMed  Google Scholar 

  53. Lee KH, Kuo HC (2019) Recovery of voiding efficiency and bladder function in male patients with non-neurogenic detrusor underactivity after transurethral bladder outlet surgery. Urology 123:235–241

    Article  PubMed  Google Scholar 

  54. Lee CL, Jhang JF, Ho HC, Jiang YH, Hsu YH, Kuo HC (2022) Therapeutic outcome of active management in male patients with detrusor underactivity based on clinical diagnosis and videourodynamic classification. Sci Rep 12:362

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Chen JL, Kuo HC (2009) Long-term outcomes of augmentation enterocystoplasty with an ileal segment in patients with spinal cord injury. J Formos Med Assoc 108:475–480

    Article  PubMed  Google Scholar 

  56. Kuo HC (1997) Clinical outcome and quality of life after enterocystoplasty for contracted bladders. Urol Int 58:160–165

    Article  CAS  PubMed  Google Scholar 

  57. Gobeaux N, Yates DR, Denys P, Even-Schneider A, Richard F, Chartier-Kastler E (2012) Supratrigonal cystectomy with Hautmann pouch as treatment for neurogenic bladder in spinal cord injury patients: long-term functional results. Neurourol Urodyn 31:672–676

    Article  PubMed  Google Scholar 

  58. Stöhrer M, Kramer G, Goepel M, Löchner-Ernst D, Kruse D, Rübben H (1997) Bladder autoaugmentation in adult patients with neurogenic voiding dysfunction. Spinal Cord 35:456–462

    Article  PubMed  Google Scholar 

  59. Skobejko-Wlodarska L, Strulak K, Nachulewicz P, Szymkiewicz C (1998) Bladder autoaugmentation in myelodysplastic children. Br J Urol 81(Suppl 3):114–116

    Article  PubMed  Google Scholar 

  60. Pannek J, Wöllner J (2022) Management of stress urinary incontinence in female patients with spinal cord injury by autologous fascial sling: time for a revival? Spinal Cord Ser Cases 8:57

    Article  PubMed  PubMed Central  Google Scholar 

  61. Abdullah A, Machkour F, Bouchet E, Plainard X, Descazeaud A (2019) Efficacy of the VIRTUE male quadratic sling in the treatment of stress urinary incontinence: a retrospective study. Prog Urol 29:490–495

    Article  CAS  PubMed  Google Scholar 

  62. Deytrikh A, Downey AP, Mangera A, Reid SV (2022) Autologous fascial slings for stress urinary incontinence in patients with neuropathic bladder. Spinal Cord Ser Cases 8:25

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Chen SF, Lee YK, Kuo HC (2022) Satisfaction with urinary incontinence treatments in patients with chronic spinal cord injury. J Clin Med 11:5864

    Article  PubMed  PubMed Central  Google Scholar 

  64. Musco S, Ecclestone H, 't Hoen L, Blok BFM, Padilla-Fernández B, Del Popolo G, Groen J, Pannek J, Kessler TM, Karsenty G, Phé V, Sartori AM, Castro-Diaz D, Rizwan H (2022) Efficacy and Safety of Surgical Treatments for Neurogenic Stress Urinary Incontinence in Adults: A Systematic Review. Eur Urol Focus 8:1090-1102

  65. Farag F, Koens M, Sievert KD, De Ridder D, Feitz W, Heesakkers J (2016) Surgical treatment of neurogenic stress urinary incontinence: a systematic review of quality assessment and surgical outcomes. Neurourol Urodyn 35:21–25

    Article  PubMed  Google Scholar 

  66. Krasmik D, Krebs J, van Ophoven A, Pannek J (2014) Urodynamic results, clinical efficacy, and complication rates of sacral intradural deafferentation and sacral anterior root stimulation in patients with neurogenic lower urinary tract dysfunction resulting from complete spinal cord injury. Neurourol Urodyn 33:1202–1206

    Article  CAS  PubMed  Google Scholar 

  67. van Ophoven A, Engelberg S, Lilley H, Sievert KD (2021) Systematic literature review and meta-analysis of sacral neuromodulation (SNM) in patients with neurogenic lower urinary tract dysfunction (NLUTD): over 20 years’ experience and future directions. Adv Ther 38:1987–2006

    Article  PubMed  PubMed Central  Google Scholar 

  68. Kuo HC (1998) Quality of life after active urological management of chronic spinal cord injury in eastern Taiwan. Eur Urol 34:37–46

    Article  CAS  PubMed  Google Scholar 

  69. Wu SY, Kuo HC (2022) Satisfaction with surgical procedures and bladder management of chronic spinal cord injured patients with voiding dysfunction who desire spontaneous voiding. J Pers Med 12:1751

    Article  PubMed  PubMed Central  Google Scholar 

  70. Stöhrer M, Madersbacher H, Richter R, Wehnert J, Dreikorn K (1999) Efficacy and safety of propiverine in SCI-patients suffering from detrusor hyperreflexia–a double-blind, placebo-controlled clinical trial. Spinal Cord 37:196–200

    Article  PubMed  Google Scholar 

  71. Hsu LN, Jhang JF, Ou YC, Chuang YC, Jang MY, Chin CW, Juan YS, Yang MH, Lin WY, Liu HH, Li JR, Kuo HC, and Taiwan Continence Society Spinal Cord Injury Study Group (2023) Clinical guidelines of patient-centered bladder management of neurogenic lower urinary tract dysfunction due to chronic spinal cord injury – Part 4: Patient Risk, Bladder Management, and Active Surveillance. Urol Sci Jun 19. (Ahead of print publication)

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This work was supported by Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, grant number: TCMF-MP 110-03-01.

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Correspondence to Sheng-Fu Chen or Hann-Chorng Kuo.

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Chen, SF., Kuo, HC. Management of spinal cord injury patients with neurogenic lower urinary tract dysfunction using minimally invasive and surgical therapies in Taiwan. Int Urol Nephrol 56, 1205–1216 (2024). https://doi.org/10.1007/s11255-023-03884-8

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