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Bibliometric study and review of Klotho research: global characteristics and trends from 2000 to 2023

  • Nephrology - Review
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Abstract

Background

Although Klotho-related research has seen a significant upsurge, the field lacks comprehensive analytical representation and in-depth exploration of pertinent areas such as prevailing research trends and key focus areas.

Method

This review presents a bibliometric analysis of literature data gathered from the Web of Science Core Collection databases from January 1, 2000, to April 30, 2023. Parameters such as co-authorship, co-citation, co-occurrence, and the emergence of publications, countries, categories, references, and keywords were scrutinized predominantly using Citespace software.

Results

Our investigation amassed a total of 3548 papers, with the United States leading in the quantity of publications (1175, accounting for 33.12%), followed by China (867, representing 24.44%), and Japan (439, accounting for 12.37%). While the United States is preeminent in the overall volume of publications, Scotland holds prominence in terms of centrality. Out of a total of 96 subject categories, urology and nephrology (573), and endocrinology and metabolism (542) were the two leading domains of Klotho-related publications. The 2011 paper titled “FGF23 induces left ventricular hypertrophy” by Faul C et al. holds the distinction of being the most frequently cited. The keywords “fibroblast growth factor 23,” “phosphate homeostasis,” and “functional variants” demonstrated the highest intensity, underscoring the potential of these research areas.

Conclusion

As the volume of literature grows, the role of Klotho in disease management and its applicability as a marker in disease progression warrant vigilant tracking and study.

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Data availability

Data supporting the findings of this study are available in “figshare” , at https://doi.org/10.6084/m9.figshare.24152898 and https://doi.org/10.6084/m9.figshare.24152895 and https://doi.org/10.6084/m9.figshare.24152835.

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Funding

This work has been awarded by the State Administration of Traditional Chinese Medicine Key Discipline Construction Project (No.1242000309), Jiangxi Provincial Administration of Traditional Chinese Medicine Key Research Laboratory on the Fundamentals of Chinese Medicine Evidence (Gan TCM Science and Education Word [2022] No.8-4), Jiangxi Province Traditional Chinese Medicine Young Chinese Backbone Talent Training Project (Gan TCM Comprehensive Word [2020] No.9]), Jiangxi University of Traditional Chinese Medicine School-level Science and Technology Innovation Team (CXTD22016), Science and Technology Research Project of Jiangxi Provincial Department of Education (GJJ211247), National Student Innovation and Entrepreneurship Training Program of Jiangxi University of Traditional Chinese Medicine (202310412002), Postgraduate Innovation Special Fund Project of Jiangxi University of Traditional Chinese Medicine (JZYC22S19).

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Authors and Affiliations

  1. Graduate School, Jiangxi University of Traditional Chinese Medicine, Jiangxi, China

    Fen-Fen Zhang, Yue-Qi Xu, Jiang-Hao Xiong & Jun-Xia Hu

  2. College of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, No.1688 Meiling Avenue, Nanchang, 33004, Jiangxi Province, China

    Guo-Shuang Zhu & Shao-Min Cheng

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Contributions

FF-Z: performed data collection, analysis and interpretation, and manuscript writing. YQ-X, JH-X, and JX-H: participated in data collection and analysis, and GS-Z and SM-C: performed the study conception and design, financial support, and manuscript approval. All authors have read and approved the final content of this manuscript.

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Correspondence to Guo-Shuang Zhu or Shao-Min Cheng.

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The current study is entirely a literature review, which utilized the Science Citation Index database. Ethical approval and informed consent are not necessary as the study did not involves human participants and/or animals.

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Zhang, FF., Xu, YQ., Xiong, JH. et al. Bibliometric study and review of Klotho research: global characteristics and trends from 2000 to 2023. Int Urol Nephrol 56, 1045–1056 (2024). https://doi.org/10.1007/s11255-023-03792-x

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