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The association of dyslipidemia with kidney stone: result from the NHANES 2007–2020

  • Urology - Original Paper
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Abstract

Objective

To examine the association between dyslipidemia and kidney stone disease (KSD).

Methods

A cross-sectional study data from 2007 to 2020 National Health and Nutrition Examination Survey (NHANES) were analyzed. Multivariate logistic regression was conducted with serum lipid levels as the exposure and presence of KSD as the outcome, and included adjustment for confounders and subgroup analysis.

Results

A total of 38,617 participants were enrolled and classified into two groups according to whether they ever had (n = 3689) or did not have (n = 34,928) KSD. After multivariate logistic regression models, compared to quartile 1 (Q1) of lipid profile, the participants in Q3 (OR 0.8380; 95 CI 0.7380, 0.9515, P < 0.01) and Q4 (OR 0.7373; 95 CI 0.6377, 0.8525, P < 0.01) of high-density lipoprotein cholesterol (HDL) had a significantly lower risk of KSD in adjusted model 3. Results remained stable after stratified by age, gender, and body mass index (BMI) in subgroup analysis. No association was observed between low-density lipoprotein cholesterol (LDL), total cholesterol (TC) and triglycerides (TG) levels, and KSD.

Conclusions

Low HDL was associated with a higher risk of kidney stones in the USA adult population.

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Availability of data and materials

The datasets generated during the current study are available in the public database (NHANES) (https://www.cdc.gov/nchs/nhanes/).

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Funding

This work was supported by the National Natural Science Foundation of China (81770705 to Hequn Chen); Central South University Independent Exploration and Innovation Project for Graduate Students (2021zzts0348 to Zewu Zhu).

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Authors and Affiliations

  1. Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, China

    Meng Gao, Minghui Liu, Zewu Zhu & Hequn Chen

  2. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

    Meng Gao, Zewu Zhu & Hequn Chen

Authors
  1. Meng Gao
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  2. Minghui Liu
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  3. Zewu Zhu
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  4. Hequn Chen
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Contributions

MG: conceptualization, visualization, methodology, writing original draft. ZZ: validation, data curation, investigation. ML: methodology, software, formal analysis. ZZ and HC: conceptualization, project administration, supervision. All authors reviewed the manuscript.

Corresponding authors

Correspondence to Zewu Zhu or Hequn Chen.

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The authors declare no conflict of interest.

Ethics approval

Approval of the study from the National Center of Health and Statistics Research ethics review board was waived because the research relied on publicly used, de-identified secondary data.

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Gao, M., Liu, M., Zhu, Z. et al. The association of dyslipidemia with kidney stone: result from the NHANES 2007–2020. Int Urol Nephrol 56, 35–44 (2024). https://doi.org/10.1007/s11255-023-03784-x

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  • DOI: https://doi.org/10.1007/s11255-023-03784-x

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