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Secondary tumours in orthotopic neobladder using isolated gut segment post radical cystectomy for urothelial carcinoma: a systematic review

  • Urology - Original Paper
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Abstract

Background

Urothelial carcinoma recurrence of an orthotopic neobladder created from bowel segment is a rare occurrence. The usage of bowel segments to create neobladder following cystectomy for urinary diversion is growing yet there still remains a large gap in the literature about recurrence in neobladder. We carry out the first systematic review to outline current details of urothelial cancer recurrences in a neobladder, diagnostic approach, management and long term prognosis.

Method

We carried out a systematic review searching databases PubMed (MEDLINE), Scopus and Web of Science. Only studies reporting on urothelial carcinoma recurrence of the neobladder with or without multi-focal disease were reported. A quality assessment tool was utilized to ensure all studies met quality standards.

Results

Fifteen studies were included in the systematic review meeting inclusion criteria. Fourteen of these studies were cases in men where pT3 disease was the most prevalent (29%). The most common symptomology was macroscopic haematuria seen in eight patients (53.33%). Management varied among cases and including adjuvant chemotherapy regimens and surgical interventions consisting of endoscopic resection to robotic neocystectomy and nephroureterectomy. Follow up period for these patients was up to 38 months and 55% of patients did not see a recurrence.

Conclusion

The nature of recurrence is hypothesised to be due to seeding of urothelial cells into the non-urothelial surfaces compatible for both implantation and growth. We present the first systematic review to report on recurrence rates and details of diagnosis and outcomes of various management regimes for urothelial carcinoma of the neobladder.

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Data availability

The data that support the findings of this study are openly available on pubmed.

References

  1. Saginala K, Barsouk A, Aluru JS, Rawla P, Padala SA, Barsouk A (2020) Epidemiology of bladder cancer. Med Sci (Basel) 8(1):15

    CAS  PubMed  Google Scholar 

  2. Hautmann RE, Volkmer BG, Schumacher MC, Gschwend JE, Studer UE (2006) Long-term results of standard procedures in urology: the ileal neobladder. World J Urol 24(3):305–314

    Article  PubMed  Google Scholar 

  3. Picozzi S, Ricci C, Gaeta M, Ratti D, Macchi A, Casellato S, Bozzini G, Carmignani L (2012) Upper urinary tract recurrence following radical cystectomy for bladder cancer: a meta-analysis on 13,185 patients. J Urol 188(6):2046–2054

    Article  PubMed  Google Scholar 

  4. Ma LL, Wang YY, Yang ZH et al (2020) Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: what are they and which is better? Mil Med Res 7:7

    PubMed  PubMed Central  Google Scholar 

  5. Pardalidis PN, Andriopoulos NA, Kosmaoglou EV, Pardalidis VN, Pardalidis NP (2020) Urothelial carcinoma recurrence in an ileal orthotopic neobladder 10 years after primary robotic radical cystoprostatectomy. J Endourol Case Rep 6(1):16–18

    Article  PubMed  PubMed Central  Google Scholar 

  6. Cherbanyk F, Prod’homme M, Pezzetta E, Chevaux B, Anaye A, Boillat JJ (2016) Urothelial Carcinoma recurrence in an ileal neobladder nine years after primary surgery with Muir-Torre syndrome. Case Rep Urol 2016:4762514

    PubMed  PubMed Central  Google Scholar 

  7. Doshi CP, Barkan GA, Quek ML (2019) Urothelial carcinoma recurrence in an orthotopic neobladder without urethral or upper urinary tract involvement. Case Rep Urol 5(2019):8458706

    Google Scholar 

  8. Groen VH, Lock TMTWT, Keizer B, Horenblas S, Meijer RP (2017) Urothelial carcinoma in an orthotopic neobladder: an unusual pattern of recurrence and metastasis. BMJ Case Rep. https://doi.org/10.1136/bcr-2017-221052

    Article  PubMed  PubMed Central  Google Scholar 

  9. Cakmak O, Tarhan H, Celik O, Kucuk U, Ilbey YO (2014) Transitional cell carcinoma in orthotopic ileal neobladder. Case Rep Urol 2014:218615

    PubMed  PubMed Central  Google Scholar 

  10. Kawamoto B, Honda M, Iwamoto H, Morizane S, Hikita K, Takenaka A (2016) Urothelial carcinoma recurrence at an ileal orthotopic neobladder and unilateral lower ureter after surgery. Urol Case Rep 17(9):27–29

    Article  Google Scholar 

  11. Ide H, Kikuchi E, Shinoda K, Mukai M, Murai M (2007) Carcinoma in situ developing in an ileal neobladder. Urology 69(3):576.e9–11

    Article  PubMed  Google Scholar 

  12. Moore CD, Iczkowski KA, Blue KM, Algood CB (2007) Urothelial carcinoma recurrence in ileal orthotopic neobladder: urethrectomy and creation of ileal conduit. Urology 69(1):184.e11–3

    Article  PubMed  Google Scholar 

  13. Sánchez Zalabardo D, López Ferrandis J, Arocena García-Tapia J, Sanz Pérez G, ZudaireBergera J, Berían Polo JM (2001) Recurrent urothelial tumor in orthotopic neobladder. Actas Urol Esp 25(8):600–602

    Article  PubMed  Google Scholar 

  14. Hadzi-Djokić J, Pejcić T, Andrejević V, Djurasić L (2013) Transitional cell carcinoma in orthotopic ileal neobladder 12 years after radical cystectomy. Vojnosanit Pregl 70(11):1062–1064

    Article  PubMed  Google Scholar 

  15. Moeen A (2015) Recurrence of isolated transitional cell carcinoma in an orthotopic ileal neobladder: a case report. Afr J Urol 21:214–216

    Article  Google Scholar 

  16. Yamashita R, Matsuzaki M, Niwakawa M, Ito I (2014) Bacillus calmette-guerintreatment of urothelial carcinoma arising in the ileal neobladder after radical cystectomy. Int J Urol 21:333–334

    Article  PubMed  Google Scholar 

  17. Hara I, Hara S, Miyake H et al (2003) Carcinoma in situ spread to mucosa of sigmoid colon neobladder. Urology 62:145

    Article  PubMed  Google Scholar 

  18. Herawi M, Leppert JT, Thomas GV et al (2006) Implants of non-invasive papillary urothelial carcinoma in peritoneum and ileocolonic neobladder: support for seed and soil hypothesis of bladder recurrence. Urology 67:746–750

    Article  PubMed  Google Scholar 

  19. Dadikhi K, Mueller F, Montani M, Thalmann GN, Kiss B (2022) Case of the Month from the University Hospital of Bern, Switzerland: Urothelial carcinoma in an orthotopic neobladder: reported cases and pathophysiological hypotheses. BJU Int 130(1):38–42

    Article  PubMed  Google Scholar 

  20. Skrodzki WJ, Głuchowski J, Weli-Wegbe J, Blawat A, Kordasz J (2014) Tumor growth in intestinal neobladder. Cent Eur J Urol 66(4):431–433

    Google Scholar 

  21. Donat SM (2006) Staged based directed surveillance of invasive bladder cancer following radical cystectomy: valuable and effective? World J Urol 24:557–564

    Article  PubMed  Google Scholar 

  22. Uguet-Perez J, Palou J, Millan-Rodriguez F et al (2001) Up-per tract transitional cell carcinoma following cystectomy for bladder cancer. Eur Urol 40:318–323

    Article  Google Scholar 

  23. Kirkali Z, Tuzel E (2003) Transitional cell carcinoma of the ureter and renal pelvis. Crit Rev Oncol Hematol 47:155–169

    Article  PubMed  Google Scholar 

  24. Oehlschläger S, Baldauf A, Wiessner D et al (2000) Bladder tumor recurrence after primary surgery for transitional cell carcinoma of the upper urinary tract. Urol Int 73:209–211

    Article  Google Scholar 

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Authors and Affiliations

  1. Redcliffe Hospital, Redcliffe, QLD, 4020, Australia

    Arya Bahadori, Gerard Bray & Nick Rukin

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  1. Arya Bahadori
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Correspondence to Arya Bahadori.

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Bahadori, A., Bray, G. & Rukin, N. Secondary tumours in orthotopic neobladder using isolated gut segment post radical cystectomy for urothelial carcinoma: a systematic review. Int Urol Nephrol 56, 519–525 (2024). https://doi.org/10.1007/s11255-023-03745-4

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  • DOI: https://doi.org/10.1007/s11255-023-03745-4

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