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Mitophagy in renal interstitial fibrosis

  • Nephrology - Review
  • Published:
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Abstract

As a high energy consumption organ, kidney relies on a large number of mitochondria to ensure normal physiological activities. Under specific stimulation, mitophagy and mitochondrial dynamics (fission, fusion) cooperatively regulate mitochondrial quality and participate in many life activities such as energy metabolism, inflammatory response, oxidative stress, cell senescence and death. Mitophagy plays a key role in the progression of acute kidney injury and chronic kidney disease. The early induction of oxidative stress in renal parenchyma, the activation of pro-inflammatory cytokines and TGF-β signal pathway are closely related to renal interstitial fibrosis. Macrophage reprogramming is also considered to be an important participant in the progression of kidney fibrosis. This review summarizes the molecular mechanism of mitochondrial autophagy and its relationship with the pathway of promoting fibrosis, and discusses the possibility of restoring mitophagy balance as a pharmacological target for the treatment of renal interstitial fibrosis, so as to provide new ideas for more efficient anti-fibrosis and delay the progress of chronic kidney disease.

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Funding

This work received support by the Joint Fund for Innovation and Development of Natural Science Foundation of Shandong Province, China (ZR2022LZY005).

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  1. Jun Sun and Chong Liu have contributed equally to this work and are the co-first authors.

Authors and Affiliations

  1. College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China

    Jun Sun & Chong Liu

  2. Department of Nephrology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China

    Ying-Ying Liu & Zhao-An Guo

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  1. Jun Sun
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  2. Chong Liu
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Z-AG and Y-YL conceived the study. JS and CL wrote and revised the manuscript. Y-YL revised the manuscript. All the authors contributed to the article and approved the submitted version.

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Correspondence to Zhao-An Guo.

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Sun, J., Liu, C., Liu, YY. et al. Mitophagy in renal interstitial fibrosis. Int Urol Nephrol 56, 167–179 (2024). https://doi.org/10.1007/s11255-023-03686-y

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