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A single-center clinical study of acute kidney injury associated with acute myocardial infarction

  • Nephrology - Original Paper
  • Published:
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Abstract

Objective

To investigate the risk factors of acute kidney injury (AKI) patients with acute myocardial infarction (AMI) and establish potential microRNA (miRNA) biomarkers in the peripheral blood of AMI–AKI patients.

Methods

Patients hospitalized from 2016 to 2020 and diagnosed with AMI (with AKI or without AKI groups) were recruited. The data of the two groups were compared and the risk factors of AMI–AKI were analyzed by logistic regression. The receiver operator characteristics (ROC) curve was drawn and the predictive value of risk factors in AMI–AKI was evaluated. Six AMI–AKI patients were selected and six healthy subjects were enrolled as the control. The peripheral blood samples of the two groups were collected for miRNA high-throughput sequencing.

Results

A total of 300 AMI patients were collected, including 190 patients with AKI and 110 patients without AKI. Multivariate logistic regression analysis indicated that diastolic pressure (68–80 mmHg), urea nitrogen, creatinine, serum uric acid (SUA), aspartate aminotransferase (AST), and left ventricular ejection fraction were the dependent risk factors of AMI–AKI patients (P < 0.05). ROC curve showed that the incidence of AMI–AKI patients was most correlated with urea nitrogen, creatinine, and SUA. In addition, 60 differentially expressed miRNAs were identified between AMI–AKI and controls. Then, hsa-miR-2278, hsa-miR-1827, and hsa-miR-149-5p were more corrected with predictors. Twelve of them targeted 71 genes involved in phagosome, oxytocin signaling pathway, and microRNAs in cancer pathways.

Conclusion

Urea nitrogen, creatinine, and SUA were the dependent risk factors and important predictors for AMI–AKI patients. Three miRNAs may be considered as biomarkers for AMI–AKI.

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Data availability

The datasets generated during and analyzed during the current study are publicly available. We have published the relevant data on Genome sequence archive (https://ngdc.cncb.ac.cn/gsa/).

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Acknowledgements

We would like to give our sincere appreciation to the reviewers for their helpful comments on this article.

Funding

This study is funded by the National Natural Science Foundation of China (81860125) and the Youth fund of Natural Science Foundation of Xinjiang Uygur Autonomous Region (2017D01C342).

Author information

Authors and Affiliations

  1. Nephrology Center, The First Affiliated Hospital of Xinjiang Medical University, No. 137 Xinshi Area, Urumqi, 830000, China

    Xuan Huang & Suhua Li

  2. Heart Center, The First Affiliated Hospital of Xinjiang Medical University, No. 137 Xinshi Area, Urumqi, 830000, China

    Muhuyati Mulasihan

  3. The First People’s Hospital of Kashi Region, Yingbin Road, Kashi, 844099, China

    Mireayi Tudi

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  1. Xuan Huang
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  4. Suhua Li
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Contributions

XH performed molecular experiments and wrote this manuscript. MM prepared the samples and collected clinical information. MT performed statistical analyses. SL reviewed and edited the manuscripts. All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Suhua Li.

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Conflict of interest

The authors declare that the study was conducted without any commercial or financial relationship and can be understood as free of any potential conflict of interest.

Ethical approval and consent to participate

The specimens used in this study were approved by the ethics committee of the First Affiliated Hospital of Xinjiang Medical University (approval number: K202003-01) and all experiments were performed with informed consent.

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All authors approved the final manuscript and the submission to this journal.

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Huang, X., Mulasihan, M., Tudi, M. et al. A single-center clinical study of acute kidney injury associated with acute myocardial infarction. Int Urol Nephrol 56, 325–334 (2024). https://doi.org/10.1007/s11255-023-03676-0

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  • DOI: https://doi.org/10.1007/s11255-023-03676-0

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