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The effect of adding Montelukast to oxybutynin on daily urination in children with pollakiuria: a randomized clinical trial

  • Urology - Original Paper
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Abstract

Purpose

Pollakiuria is defined as a change in the pattern of daily urination. Students have mentioned wetting their pants at school as the third tragic event after the death of a parent or going blind. In this study, the effect of adding Montelukast to oxybutynin on the improvement of urinary symptoms of patients with pollakiuria was studied.

Materials and methods

This study was a pilot clinical trial in which children with pollakiuria aged 3–18 years old were included. These children were randomly divided into two groups of intervention (Montelukast plus oxybutynin) and the control group (only oxybutynin). At the beginning and the end of the study (after 14 days), mothers were asked about the frequency of daily urination. Finally, the gathered data were compared between two groups.

Results

In the present study, 64 patients were examined in two intervention and control groups (32 in each group). The results revealed that although significant changes were observed in both groups before and after intervention, the average changes in the intervention group were significantly higher (p = 0.014).

Conclusion

The results of this study showed that adding montelukast to oxybutynin has a significant decrease in frequency of daily urination in patients with pollakiuria, although further studies are recommended in this area.

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Availability of data and materials

The datasets used and analyzed during the current study are available to be collected from the corresponding author on reasonable request.

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Acknowledgements

The authors would like to thanks Arak University of Medical Sciences for their scientific and financial support.

Funding

This study was funded by Vice-chancellor for Research of Arak University of Medical Sciences.

Author information

Authors and Affiliations

  1. Department of Pediatrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran

    Ali Arjmand Shabestari, Fatemeh Dorreh & Parsa Yousefichaijan

  2. Students Research Committee, Arak University of Medical Sciences, Arak, Iran

    Hamide Bakhtiari

  3. Infectious Disease Research Center (IDRC), Arak University of Medical Sciences, Arak, Iran

    Fatemeh Dorreh & Amir Almasi-Hashiani

  4. Department of Epidemiology, School of Health, Arak University of Medical Sciences, Basij Square, Arak, Iran

    Amir Almasi-Hashiani

  5. Traditional and Complementary Medicine Research Center (TCMRC), Arak University of Medical Sciences, Arak, Iran

    Ali Arjmand Shabestari, Hamide Bakhtiari, Fatemeh Dorreh, Parsa Yousefichaijan & Amir Almasi-Hashiani

Authors
  1. Ali Arjmand Shabestari
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  2. Hamide Bakhtiari
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  3. Fatemeh Dorreh
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  4. Parsa Yousefichaijan
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  5. Amir Almasi-Hashiani
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Contributions

Study conception and design: AAS, HB, FD, PY, and AAH. Data collection, statistical expertise, analysis and interpretation of data: AAS, HB and AAH. Manuscript preparation, supervision, administrative support and critical revision of the paper: AAS, HB, FD, PY and AAH. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Amir Almasi-Hashiani.

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Conflict of interest

All authors declared that they have no conflict of interest.

Ethical approval and consent to participate

All stages of research were conducted following the Declaration of Helsinki and the Ethical Statements of the Ethics Committee of Arak University of Medical Sciences. This study was approved by the Ethics Committee of Arak University of Medical Sciences (Ethical code: IR.ARAKMU.REC.1400.054). The parents or legal guardians of subjects provided written informed consent on their behalf. The children were also asked verbally if they were willing to participate in the study.

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Arjmand Shabestari, A., Bakhtiari, H., Dorreh, F. et al. The effect of adding Montelukast to oxybutynin on daily urination in children with pollakiuria: a randomized clinical trial. Int Urol Nephrol 55, 2139–2144 (2023). https://doi.org/10.1007/s11255-023-03673-3

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  • DOI: https://doi.org/10.1007/s11255-023-03673-3

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