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Combinative predictive effect of left ventricular mass index, ratio of HDL and CRP for progression of chronic kidney disease in non-dialysis patient

  • Nephrology - Original Paper
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Abstract

Purpose

This current study scrutinized the association among left ventricular mass index (LVMI), ratio of high-density lipoprotein (HDL) and C-reactive protein (CRP), and renal function. Furthermore, we examined the predictive effects of left ventricular mass index and HDL/CRP on progression of non-dialysis chronic kidney disease.

Methods

We enrolled adult patients with chronic kidney disease (CKD) who were not receiving dialysis and obtained follow-up data on them. We extracted and compared data between different groups. To investigate the relationship between left ventricular mass index (LVMI), high-density lipoprotein (HDL)/C-reactive protein (CRP) levels, and CKD, we employed linear regression analysis, Kaplan–Meier analysis, and Cox proportional hazards regression analysis.

Results

Our study enrolled a total of 2351 patients. Compared with those in the non-progression group, subjects in the CKD progression group had lower ln(HDL/CRP) levels (− 1.56 ± 1.78 vs. − 1.14 ± 1.77, P < 0.001) but higher left ventricular mass index (LVMI) values (115.45 ± 29.8 vs. 102.8 ± 26.31 g/m2, P < 0.001). Moreover, after adjusting for demographic factors, ln(HDL/CRP) was found to be positively associated with estimated glomerular filtration rate (eGFR) (B = 1.18, P < 0.001), while LVMI was negatively associated with eGFR (B = − 0.15, P < 0.001). In the end, we found that both LVH (HR = 1.53, 95% CI 1.15 to 2.05, P = 0.004) and lower ln(HDL/CRP) (HR = 1.46, 95% CI 1.08 to 1.96, P = 0.013) independently predicted CKD progression. Notably, the combined predictive power of these variables was stronger than either variable alone (HR = 1.98, 95% CI 1.5 to 2.62, P < 0.001).

Conclusion

Our study findings indicate that in pre-dialysis patients, both HDL/CRP and LVMI are associated with basic renal function and are independently correlated with CKD progression. These variables may serve as predictors for CKD progression, and their combined predictive power is stronger than that of either variable alone.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

This work was supported by: Key Project of Basic and Applied Basic Research Fund of Guangdong Province (No. 2020B1515120037) to Dr Xun Liu; Special Fund for Clinical Medical Research of the Third Affiliated Hospital of Sun Yat-sen University (No. YHJH201806) to Dr Xun Liu. The National Natural Science Foundation of China (Grant No.81873631, 81370866, 81070612) to Dr Xun Liu; The Guangzhou Science and technology planning project (Grant No.202002020047) to Dr Xun Liu; NSFC-Guangdong United Fund (Grant No. 2020B1515120037) to Dr Xun Liu.

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Author notes

  1. Leile Tang and Shaomin Li have contributed equally to this paper.

Authors and Affiliations

  1. Department of Cardiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China

    Leile Tang

  2. Department of Nephrology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, Guangdong, China

    Shaomin Li, Jiahui Lai, Peijia Liu, Jia Fang & Xun Liu

  3. Department of Rheumatology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China

    Xinghua Guo

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Contributions

LT, SL, JL, XG, PL, JF—analysis and interpretation of data and preparation of the manuscript. XL—study concept and design, and preparation and critical review of the manuscript. XL—critical review and statistical guidance of the revised manuscript. All authors have approved the final manuscript.

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Correspondence to Xun Liu.

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Tang, L., Li, S., Guo, X. et al. Combinative predictive effect of left ventricular mass index, ratio of HDL and CRP for progression of chronic kidney disease in non-dialysis patient. Int Urol Nephrol 56, 205–215 (2024). https://doi.org/10.1007/s11255-023-03624-y

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