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Perioperative change of circulating tumor cells in cytoreductive radical prostatectomy for oligometastatic hormone-sensitive prostate cancer: the preliminary safety evidence from long-term oncologic outcomes

  • Urology - Original Paper
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Abstract

Surgical manipulation has a risk of triggering the shedding of circulating tumor cells (CTCs) in patients with malignancies, However, perioperative change of circulating tumor cells in cytoreductive radical prostatectomy (CRP) for patients with oligometastatic hormone-sensitive prostate cancer (omHSPC) has not yet been well documented. This study aimed to assess whether CRP is a safe procedure for patients with omHSPC by monitoring the perioperative change of CTCs and investigating its impact on long-term oncologic outcomes. We have observed a significant decrease between the median CTC counts before and after surgery (6 vs. 4, p = 0.026). Comparing preoperative and postoperative CTC levels, seven patients increased (CTC increase group), one did not change and nineteen decreased (CTC non-increase group). PSA response rates in CTC increase group were lower than those in CTC non-increase group (73.0% vs 99.8%, p = 0.162), and nadir PSA was higher in CTC increase group (0.043 vs 0.003, p = 0.072). The CTC increase was positively correlated with the nadir PSA (r = 0.386, p = 0.047). The median follow-up period was 71.6 months, we found that there was no significant difference in clinical-pathological, operative variables or long-term oncologic outcomes between perioperative CTC increase and non-increase groups. In the entire cohort, the CTC level significantly decreased after surgery. There was no significant differences in long-term oncologic outcomes between the CTC increase and non-increase groups, implying that CRP potentially represents a safe procedure for the treatment of patients with omHSPC. The results need to be confirmed in a prospective large-scale clinical trial.

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Data availability

The data that support the findings of this study are available upon request from the corresponding author yaoxudong1967@163.com and yangbnju@gmail.com.

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Acknowledgements

We thank Bullet Edits ( www.bulletedits.cn) for editing and proofreading this manuscript.

Funding

This study was supported by the National Natural Science Foundation of China (Grant no. 81472389 to Yao; Grant no. 31570993 to Yang).

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Author notes

  1. Niraj Maskey, Shiyu Mao and Guanjie Yang have contributed equally to this work.

Authors and Affiliations

  1. Department of Urology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 301 Middle Yan Chang Road, Shanghai, 200072, People’s Republic of China

    Niraj Maskey, Shiyu Mao, Guanjie Yang, Yadong Guo, Aimaitiaji Kadier, Jing Yuan, Changcheng Guo, Bin Yang & Xudong Yao

  2. Urologic Cancer Institute, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China

    Niraj Maskey, Shiyu Mao, Guanjie Yang, Yadong Guo, Aimaitiaji Kadier, Jing Yuan, Changcheng Guo, Bin Yang & Xudong Yao

  3. Shanghai Clinical College, Anhui Medical University, 81 Meishan Road, Hefei, 230032, People’s Republic of China

    Jun Xie & Xudong Yao

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  1. Niraj Maskey
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Contributions

Conception and design: XY; BY. Administrative support: CG. Provision of study materials or patients: AK; JY; CG. Collection and assembly of data: SM; NM; GY; YG. Data analysis and interpretation: SM; NM; JX. Manuscript writing: all authors. Final approval of manuscript: All authors.

Corresponding authors

Correspondence to Bin Yang or Xudong Yao.

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The authors have no conflicts to disclose.

Ethics statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of Tenth People’s Hospital of Shanghai (SHSY-IEC-4.1/20-22/01). The patients/participants provided their written informed consent to participate in this study.

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11255_2023_3622_MOESM1_ESM.jpg

Supplemental Figure 1. Preoperative and postoperative counts in each of twenty-seven patients treated with cytoreductive radical prostatectomy (JPG 278 KB)

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Maskey, N., Mao, S., Yang, G. et al. Perioperative change of circulating tumor cells in cytoreductive radical prostatectomy for oligometastatic hormone-sensitive prostate cancer: the preliminary safety evidence from long-term oncologic outcomes. Int Urol Nephrol 55, 1709–1717 (2023). https://doi.org/10.1007/s11255-023-03622-0

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