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Do not forget the kidney in graves’ disease

  • Nephrology - Original Paper
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Abstract

Purpose

To investigate the prevalence of microalbuminuria and factors associated with microalbuminuria in Graves’ Disease (GD).

Methods

This cross-sectional and single-center study included 99 patients with GD and 47 healthy controls (HC). Exclusion criteria such as active infection, uncontrolled diabetes, and chronic kidney disease were applied to the participants. The participants’ clinical findings, comorbidities, drug use, laboratory tests, and thyroid antibody levels were recorded. Spot urine samples were collected and stored at – 80 ℃ to analyze the presence of microalbuminuria.

Results

The prevalence of microalbuminuria in patients with GD was 12.1%. The median microalbumin/creatinine ratio in spot urine (UACR) in patients with GD (9.49 mg/g [5.09–18.10]) was higher than in the HC group (7.99 mg/g [3.48–12.88], p = 0.033). UACR was correlated with thyroid-stimulating hormone receptor antibody (TRAb), thyroid-stimulating hormone (TSH), and free triiodothyronine (FT3) levels (p = 0.020, p = 0.006, p = 0.009 respectively). In the regression analysis, only the relationship between TRAb level and UACR remained (p = 0.040).

Conclusion

This study demonstrates an increased prevalence of microalbuminuria in patients with GD. There was a significant correlation between microalbuminuria and TRAb level in patients with GD. This relationship suggests that one of the underlying mechanisms of microalbuminuria seen in patients with GD may be autoimmunity.

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Data Availability

The data used and analyzed during the current scoping review are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. Department of Endocrinology, Metabolism, and Diabetes, Medical Faculty, Istanbul University-Cerrahpasa, Campus Kocamustafapasa Street No:53 Cerrahpasa, Fatih, 34098, Istanbul, Turkey

    Ahmet Numan Demir, Zehra Kara, Emre Durcan, Cem Sulu, Hande Mefkure Ozkaya & Mustafa Sait Gonen

  2. Department of Internal Medicine, Istanbul University-Cerrahpasa, 34098, Istanbul, Turkey

    Oznur Aydin Atar & Guldana Zulfaliyeva

  3. Department of Nephrology, Istanbul University-Cerrahpasa, 34098, Istanbul, Turkey

    Cebrail Karaca & Nurhan Seyahi

  4. Department of Medical Biochemistry, Istanbul University-Cerrahpasa, 34098, Istanbul, Turkey

    Dildar Konukoglu

Authors
  1. Ahmet Numan Demir
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  2. Zehra Kara
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  3. Emre Durcan
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  4. Cem Sulu
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  5. Oznur Aydin Atar
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  6. Guldana Zulfaliyeva
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  7. Cebrail Karaca
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  8. Hande Mefkure Ozkaya
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  9. Nurhan Seyahi
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  10. Dildar Konukoglu
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  11. Mustafa Sait Gonen
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Contributions

All authors provided substantial contributions to the design and implementation of this study and the generation of the manuscript. The contributions of each author are as follows: MSG, HMO, NS, and DK conceived the design and purpose of the work. OAA and GZ: took part in the collection of data and spot urine samples. AND, ZK, ED, CS, and CK: analyzed the data AND: interpreted the results based on the available literature and drafted the manuscript. MSG, HMÖ, and AND: made critical revisions. MSG, HMÖ, and AND: provided the final version of the article.

Corresponding author

Correspondence to Mustafa Sait Gonen.

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Conflict of interest

None of the authors have any potential conflicts of interest associated with this research.

Ethical approval

The study adhered to the ethical principles for medical research involving human participants described in the World Medical Association's Declaration of Helsinki. Istanbul University-Cerrahpaşa Ethics Committee approved the study (Approval Number: 2019-09-83045809-604.01.02).

Informed consent

Signed informed consent was obtained from all study participants.

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Demir, A.N., Kara, Z., Durcan, E. et al. Do not forget the kidney in graves’ disease. Int Urol Nephrol 55, 2667–2673 (2023). https://doi.org/10.1007/s11255-023-03600-6

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  • DOI: https://doi.org/10.1007/s11255-023-03600-6

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