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Evaluation of malnutrition and inflammation after total parathyroidectomy in patients on maintenance dialysis

  • Nephrology - Original Paper
  • Published:
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Abstract

Purpose

To evaluate the effect of total parathyroidectomy (tPTx) on malnutrition and inflammation in patients on maintenance dialysis (MHD) having secondary hyperparathyroidism (SHPT).

Methods

Twenty-five patients on MHD having SHPT who were being treated with tPTx were selected, and changes in their general condition (dry body mass), parathyroid hormone (PTH) and calcium levels, nutrition state (hemoglobin, hematocrit, serum albumin, and total iron binding capacity), and inflammatory status [serum C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor (TNF-α), and the malnutrition–inflammation score (MIS)] were observed at 12, 24, and 36 months postoperatively.

Results

Compared with the preoperative period, the dry body mass increased at 12, 24, and 36 months postoperatively (P < 0.01), hemoglobin, hematocrit, and serum albumin increased significantly (P < 0.01), whereas calcium, phosphorus, and PTH levels decreased significantly (P < 0.01). Serum CRP, IL-6, and TNF-α levels were significantly decreased at 12, 24, and 36 months after surgery (P < 0.01). Furthermore, MIS was reduced as well but to a lesser extent (P < 0.01).

Conclusion

tPTx effectively reduced MIS in maintenance dialysis patients, and the alleviated malnutrition and improved inflammatory status may contributed to improving the quality of life of patients on MHD with SHPT.

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Data availability

The data used to support the findings of this study are included within the article.

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Acknowledgements

Not applicable.

Funding

This work was supported by Gansu Longyuan young talents innovation and entrepreneurship (No. 2020RCXM127) and Lanzhou Chengguan District Science and Technology Bureau talent innovation and entrepreneurship (No. 2021RCCX0027). Meanwhile, our experiments are supported by the Clinical Medical Research Center of Gansu Province (21JR7RA436).

Author information

Authors and Affiliations

  1. Laboratory Department of Nephrology, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu, China

    Xiaochun Zhou, Yuke Kong, Wenjun Zhang, Pengming Zhao, Ya Wang, Li Ma, Gouqin Wang, Xiaoling Wang, Yaojun Liang, Xuan Du, Yaxian Ning, Rongrong Deng, Ya Tang, Weiwei Hu & Jianqin Wang

  2. Department of Nephrology, Gansu Provincial People’s Hospital, Lanzhou, 730030, Gansu, China

    Zhigang Ma

  3. Department of Nephrology, Lanzhou University First Hospital, Lanzhou, 730030, Gansu, China

    Tianxi Liu

  4. Department of Nephrology, Wuwei People’s Hospital of Gansu Province, Wuwei, 730030, Gansu, China

    Tingxin Wan

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  1. Xiaochun Zhou
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Contributions

Conceptualization: XZ, PZ, and JW; methodology: XZ, ZM, WZ, and XW; formal analysis and investigation: YK, TL, YW, YL, and RD; funding acquisition: JW; resources: TW, LM, and GW; supervision: JW; Validation: XD and YT; visualization: YN and WH; writing—original draft: XZ and YK; writing—review and editing: JW; final approval of manuscript: all the authors.

Corresponding author

Correspondence to Jianqin Wang.

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Conflict of interest

We declare that we have no conflict of interest.

Ethic approval

The study was approved by the Ethics Committee of the Second Hospital of Lanzhou University (approval number: 2020A-136).

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All the patients signed an informed consent form.

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Zhou, X., Kong, Y., Ma, Z. et al. Evaluation of malnutrition and inflammation after total parathyroidectomy in patients on maintenance dialysis. Int Urol Nephrol 55, 1301–1309 (2023). https://doi.org/10.1007/s11255-022-03436-6

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  • DOI: https://doi.org/10.1007/s11255-022-03436-6

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