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Non-typical anti-GBM disease with intraglomerular granulomatous reaction and anti-PLA2R-negative membranous nephropathy in the context of IgM/κ paraproteinemia

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Authors and Affiliations

  1. Department of Nephrology, The First Hospital of HeBei Medical University, No. 89 East DongGang Road, ShiJiaZhuang, 050030, People’s Republic of China

    WenTing Zhao, Jing Li, GuangWei Ren, LiHong Zhang & Tao Wang

  2. TaiYuan KingMed Center for Clinical Laboratory, No. 2 LongSheng Street, TaiYuan, 030000, People’s Republic of China

    Guang Yang

Authors
  1. WenTing Zhao
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  2. Jing Li
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  3. Guang Yang
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  4. GuangWei Ren
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  5. LiHong Zhang
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  6. Tao Wang
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Correspondence to Tao Wang.

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11255_2022_3424_MOESM1_ESM.jpg

Supplementary Figure 1. Results of the main diagnostic work-up. a1-a4. Immunofluorescence showing linear deposits of IgG 3+, IgG1 2+, IgM 1+ and C1q 1+ along the glomerular capillary loop, respectively. b1. Immunofluorescence of the α5 chain. b2. Electron microscope showing diffuse thickening of the GBM with a maximum thickness of 800 nm, accompanied by segmental wrinkling and formation of spikes. There were also podocytes swelling, diffuse effacement of the foot processes and electron-dense deposits under the epithelium and within the GBM. b3 and b4. CT images showing absence of pulmonary alveolar hemorrhage and normal kidney size without hydronephrosis, respectively. c1-c4. Respectively depicting monoclonal bands of the IgM and κ chain in immunofixation electrophoresis, normal bone marrow aspiration, swollen axillary lymph nodes and lymph proliferative disorder as viewed by morphology. Supplementary file1 (JPG 2273 KB)

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Zhao, W., Li, J., Yang, G. et al. Non-typical anti-GBM disease with intraglomerular granulomatous reaction and anti-PLA2R-negative membranous nephropathy in the context of IgM/κ paraproteinemia. Int Urol Nephrol 55, 1389–1391 (2023). https://doi.org/10.1007/s11255-022-03424-w

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  • DOI: https://doi.org/10.1007/s11255-022-03424-w

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