Abstract
Purpose
In our study, diagnostic and demographic characteristics of patients diagnosed with minimal change disease (MCD) by biopsy, clinical and laboratory findings in our country were investigated.
Methods
Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. The data presented are cross-sectional and includes application data for the biopsy period.
Results
Of 3875 patients, 233 patients with MCD (median age 35.0 years) were included in the study, which constitutes 6.0% of the total glomerulonephritis database. Renal biopsy was performed in 196 (84.1%) patients due to nephrotic syndrome. Median serum creatinine was 0.7 (0.6–1.0) mg/dl, mean eGFR was 104 ± 33 ml/min/1.73 m2 and median proteinuria 6000 mg/day. The number of patients under the age of 40 years was 139 (59.7%) (Group A), and the number of patients aged 40 years and over was 94 (40.3%) (Group B). Compared to Group A, global sclerotic glomeruli (24 vs. 43, p < 0.001) interstitial inflammation (15 vs. 34, p < 0.001), interstitial fibrosis (20 vs. 31, p = 0.001, vascular changes (10 vs. 25, p < 0.001) and tubular atrophy (18 vs. 30, p < 0.001) were found to be significantly higher in Group B. There was no difference in immunofluorescent staining properties between the two groups.
Conclusion
Our data are generally compatible with the literature. Chronic histopathological changes were more common in patients aged 40 years and older than younger patients. Studies investigating the effects of these different features on renal survival are needed.
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Availability of data and materials
All data and materials are registered at the Turkish Society of Nephrology Glomerular Diseases Working Group (TSN-GOLD) website (http://pgh.tsn.org.tr). All data generated or analyzed during this study are included in this published article.
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Acknowledgements
We would like to express our endless thanks to the Turkish Society of Nephrology, who organized the background of the study, and to the pathologists in each center for their contributions to patient care and their help in providing these data.
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All authors contributed to the study conception and design. All authors contributed to study material preparation, data collection. Analysis; Zeki Aydin, Murvet Yilmaz. The first draft of the manuscript was written by Zeki Aydin and Garip Sahin. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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The present study was approved by the Ethical Committee of the Istanbul Medical Faculty of Istanbul University. Informed consent was obtained from all individual participants included in the study. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee at which the studies were conducted (IRB approval number 1164/2011) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
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Aydin, Z., Yilmaz, M., Sipahioglu, M. et al. Demographic, clinical and laboratory characteristics of adult-onset minimal change disease in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group. Int Urol Nephrol 55, 975–982 (2023). https://doi.org/10.1007/s11255-022-03382-3
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DOI: https://doi.org/10.1007/s11255-022-03382-3