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The relationship between depression, anxiety, quality of life levels, and the chronic kidney disease stage in the autosomal dominant polycystic kidney disease

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Abstract

Purpose

Decreased quality of life, anxiety, depression, and other negative psychosocial factors in autosomal dominant polycystic kidney disease (ADPKD) may lead to the patient’s attitudes that reduce treatment effectiveness. We aimed to evaluate the relationship between the depression, anxiety, perceived social support, genetic psychosocial risk and quality of life levels, and chronic kidney disease (CKD) stage in ADPKD and to investigate the relationship between these variables/parameters and the dietary compliance that is an essential factor in the course of the disease.

Methods

100 ADPKD patients were enrolled in this cross-sectional study. EuroQol-5D-3L (EQ-5D-3L) health-related quality of life ındex, EuroQol-5D-3L visual analog scale (EQ-5D-3L VAS), multidimensional scale of perceived social support (MSPSS), patient health questionnaire (PHQ)-9, and genetic psychosocial risk ınstrument (GPRI) were applied to the patients.

Results

There is a relationship with negative regression coefficient between the CKD stage and the total scores of the EQ-5D-3L and EQ-5D-3L VAS scales (p < 0.000 and β =  − 5.355, p < 0.000, and β =  − 8.394, respectively). There is a relationship with positive regression coefficient between the CKD stage and MSPSS total score and level (p < 0.000 and β = 0.364, p < 0.000 and β = 0.331, respectively). There is no relationship between the CKD stage and GPRI total score (p = 0.800). In addition, there is a relationship with positive regression coefficient between the dietary compliance and EQ-5D and EQ-5D VAS total scores (p = 0.006 and β = 2.687, p = 0.004 and β = 3.148, respectively). There is a relationship with negative regression coefficient between the dietary adherence and PHQ-9 total score and CKD stage (p = 0.003, p = 0.006, and β =  − 0.692, respectively).

Conclusion

As the CKD stage increases in the ADPKD patients, the quality of life decreases, whereas the level of anxiety and depression increases. It has been seen that the ADPKD patients with more depressive complaints have less dietary compliance. In this particular patient group, the early detection and treatment of psychosocial difficulties and the work to improve the quality of life that affect the course of the ADPKD may be as important as the medical treatment. To determine the needs of ADPKD patients with multiple physical and psychosocial difficulties and to perform appropriate interventions, we think that there is a necessity for a specific scale that evaluates these effective components together in the ADPKD process.

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Authors and Affiliations

  1. Department of Internal Medicine, Diskapi Yildirim Beyazit Education and Research Hospital, University of Health Sciences, Ankara, Turkey

    Aysenur Miray Yarlioglu

  2. Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, University of Health Sciences, Ankara, Turkey

    Ebru Gok Oguz, Kadir Gokhan Atilgan, Hatice Sahin & Mehmet Deniz Ayli

  3. Department of Psychiatry, Diskapi Yildirim Beyazit Education and Research Hospital, University of Health Sciences, Ankara, Turkey

    Ayse Gokcen Gundogmus

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  1. Aysenur Miray Yarlioglu
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Correspondence to Ebru Gok Oguz.

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The present study protocol was reviewed and approved by the local ethical committee of University of Health Sciences, Diskapi Yıldırım Beyazit Training and Research Hospital (date: 25.03.2019; decision No: 61/21). Informed consent was submitted by all the subjects when they were enrolled.

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Yarlioglu, A.M., Oguz, E.G., Gundogmus, A.G. et al. The relationship between depression, anxiety, quality of life levels, and the chronic kidney disease stage in the autosomal dominant polycystic kidney disease. Int Urol Nephrol 55, 983–992 (2023). https://doi.org/10.1007/s11255-022-03375-2

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