Abstract
Purpose
The incidence of urethral recurrence (UR) following radical cystectomy (RC) for transitional cell carcinoma (TCC) of the bladder varies between 1.5 and 6%. There is debate over the timing of urethrectomy for patients undergoing RC. We evaluated the requirement for a formal surveillance programme for UR in patients after RC.
Methods
We retrospectively reviewed the outcomes of patients who underwent RC between 2006 and 2019. Females, non-TCC cases and patients with neo-bladder diversions were excluded. Histological prostatic urethral involvement at the time of RC was deemed high risk for UR. Carcinoma in-situ, multifocal tumours and bladder neck involvement were deemed intermediate risk and the absence of the above features was considered low risk.
Results
417 patients underwent RC, 300 cases remained after exclusion criteria were applied. 42 patients were high-risk for UR, 102 patients were intermediate risk and 156 were low risk. Of the 300, 24 urethrectomy cases were recorded. Six cases of UR occurred. Of these, 5 presented with symptoms and only 1 case was detected by surveillance. Only 1 low-risk patient developed UR, 7 years post RC. Using our risk stratification, UR rates for high, intermediate and low-risk cohorts were 25%, 10.5% and 0.8%, respectively.
Conclusions
In our cohort, routine surveillance for all patients with annual urethroscopy was of limited value in detecting UR post RC. Staged Urethrectomy for high and intermediate-risk patients, and patient counselling in self-identification of recurrence symptoms for low-risk patients will improve the early detection of UR.
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All authors contributed to the production of this paper. Their contribution is as follows. CMD—study concept, data analyses, writing of the paper and editing the paper. BW—data collection and analyses. KY—data collection. CNM—data analyses, paper writing, review and editing. RS—study concept, review of a paper. RC—study concept, data review, paper review and editing.
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Devlin, C.M., Molokwu, C.N., Wood, B. et al. Routine urethroscopic surveillance is of limited value after radical cystectomy: a single centre retrospective cohort analysis. Int Urol Nephrol 54, 3139–3144 (2022). https://doi.org/10.1007/s11255-022-03312-3
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DOI: https://doi.org/10.1007/s11255-022-03312-3