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Autologous testicular tunica vaginalis graft in Peyronie’s disease: a prospective evaluation

  • Urology - Original Paper
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Abstract

Background

Peyronie’s disease (PD) is a two-phase progressive condition characterized by inelastic plaques in the tunica albuginea of the penis, leading to curvature of the penis. Men with PD also suffer from psychological distress, and sexual life and overall quality of life. Although the preferred surgical treatment modality in Peyronie’s disease is plaque incision and grafting, there is lack of studies assessing the erectile function and penile vasculature after the treatment.

Objectives

We aimed to evaluate the efficiency and safety of plaque incision and tunica vaginalis of testis grafting in PD.

Methods

This was a prospective analysis. Erectile dysfunction was assessed via International Index of Erectile Function Questionnaire (IIEF-5). Penile Doppler ultrasound was performed to assess peak systolic velocity (PSV) and end-diastolic velocity (EDV). Postoperative follow-ups were scheduled at 3, 12, and 24 months.

Results

Twenty patients (mean age 47.2 ± 10.8 years) were included. The mean preoperative penile curvature was 48 ± 6.6°. The technical success rate was 100% at 3 months and 90% at 24 months. At follow-up visits, mean erect penile length was no different from the baseline. The baseline mean IIEF-5 score was 18.4 ± 2.5. The mean IIEF-5 score was 20.6 ± 2.6 at 24-month visit (p < 0.0001). Mean PSV significantly increased, while EDV significantly reduced after surgery. There were no serious complications related to surgery.

Conclusions

We conclude that surgical reconstruction of penile curvature with tunica vaginalis grafting was a safe and effective procedure in PD.

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Acknowledgements

We are grateful to 1st Hospital of Nur-Sultan, Department of Uroandrology.

Funding

None.

Author information

Authors and Affiliations

  1. Department of Urology and Andrology, Astana Medical University, Beibitshilik Street #49/a, 010000, Nur-Sultan, Kazakhstan

    Yernur Ainayev, Ulanbek Zhanbyrbekuly, Ulan Zhaparov, Makhmud Suleiman, Nurbol Keulimzhayev, Rano Zhankina & Gafur Khairli

  2. School of Medicine, Department of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan

    Abduzhappar Gaipov

  3. Department for Reception and Diagnosis, JSC ‘National Center of Neurosurgery’, Nur-Sultan, Kazakhstan

    Nurlan Kissamedenov

  4. Department of General Medical Practice No. 3, Astana Medical University, Nur-Sultan, Kazakhstan

    Saltanat Urazova

  5. Department of Microbiology and Virology Named After Sh. I. Sarbasova, Astana Medical University, Nur-Sultan, Kazakhstan

    Nurila Rakhmetova

  6. Department of Surgery with an Angiosurgery and Plastic Surgery Course, Astana Medical University, Nur-Sultan, Kazakhstan

    Dulat Turebayev

Authors
  1. Yernur Ainayev
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Contributions

Conceptualization: YIA and UZ; methodology: DT and MAS; data collection: NK, USZ, and RAZ; manuscript writing: SU, NMK, and MAS; manuscript review and editing: AEG and NR; supervision: AEG, GZK, and UZ.

Corresponding author

Correspondence to Yernur Ainayev.

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The authors have no conflict of interest to disclose.

Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Bioethics Committee of the Astana Medical University (IRB #5).

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Informed consent was obtained from all individual participants included in the study.

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Ainayev, Y., Zhanbyrbekuly, U., Gaipov, A. et al. Autologous testicular tunica vaginalis graft in Peyronie’s disease: a prospective evaluation. Int Urol Nephrol 54, 1545–1550 (2022). https://doi.org/10.1007/s11255-022-03223-3

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  • DOI: https://doi.org/10.1007/s11255-022-03223-3

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