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Heart rate variability in men with lower urinary tract symptoms: a case-control study

  • Urology - Original Paper
  • Published:
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Abstract

Purpose

Measurement of heart rate variability (HRV) allows evaluation of autonomic nervous system activity. Decreased HRV is associated with autonomic disbalance, poor health and higher mortality. Our objective is to evaluate the HRV in men with lower urinary tract symptoms (LUTS) through a case-control study.

Methods

LUTS were considered as the outcome and HRV variables were considered as exposure. The protocol included anamnesis, LUTS assessment, anthropometry, blood pressure and HRV measurement by analyzing the variation in the time interval between consecutive heartbeats or RR intervals. The mathematical study of HRV indicators allowed the assessment of the cardiac autonomic modulation of the volunteers.

Results

Eighty nine patients were included in the study, with 34 allocated to the case group (with LUTS) and 55 to the control group (without LUTS). The patients were similar in terms of age and systolic and diastolic blood pressure. Among the HRV variables, the mean VLF index for the very low frequency of the spectrum associated with the frequency domain was significantly higher in volunteers without LUTS. Control group patients presented a mean of 113.18 ± 166.74 ms2, while patients with LUTS presented a mean of 69.21 ± 61.98 ms2 (p = 0.032).

Conclusions

Men 50–59 years of age without chronic diseases and with LUTS have an unfavorable cardiac autonomic profile indicated by significantly lower levels of the VLF component of HRV compared to men without LUTS.

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Funding

There was no funding to declare.

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Authors and Affiliations

  1. NIPU - Núcleo Interdisciplinar de Pesquisa em Urologia, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil

    Christiano Silva Brum, Daniel Rocha Pedrosa, José Murillo Bastos Netto & André Avarese Figueiredo

  2. Departmento de Saúde Coletiva, Medical School, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil

    Isabel Cristina Gonçalves Leite

  3. Department of Surgery, Medical School, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil

    José Murillo Bastos Netto & André Avarese Figueiredo

Authors
  1. Christiano Silva Brum
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  2. Daniel Rocha Pedrosa
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  3. Isabel Cristina Gonçalves Leite
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  4. José Murillo Bastos Netto
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  5. André Avarese Figueiredo
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Contributions

CSB: protocol/project development, data collection, data management, data analysis, manuscript writing, manuscript editing. DRP: data collection, data management, data analysis. ICGL: manuscript writing, manuscript editing. HEL: protocol/project development, manuscript editing. JMBN: protocol/project development, manuscript editing. AAF: protocol/project development, data analysis, manuscript writing, manuscript editing.

Corresponding author

Correspondence to André Avarese Figueiredo.

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Conflict of interest

The authors states that there is no conflict of interest to report.

Ethics approval

This study was approved by the Research Ethics Committee of the University Hospital of the Federal University of Juiz de For a (number 888.619). The study was performed according with the Declaration of Helsinki.

Consent to participate

All patients assigned an informed consent to participate in the present clinical trial.

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Brum, C.S., Pedrosa, D.R., Leite, I.C.G. et al. Heart rate variability in men with lower urinary tract symptoms: a case-control study. Int Urol Nephrol 54, 1479–1484 (2022). https://doi.org/10.1007/s11255-022-03213-5

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  • DOI: https://doi.org/10.1007/s11255-022-03213-5

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