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Research progress on the relationship between IS and kidney disease and its complications

  • Nephrology - Review
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Abstract

Indoxyl sulphate (IS) a representative uraemic toxin in the blood of patients with chronic kidney disease (CKD). Its accumulation may be closely related to CKD and the increasing morbidity and mortality of the disease’s related complications. Timely and effective detection of the IS level and efficient clearance of IS may effectively prevent the progression of CKD and its related complications. Therefore, this article summarizes the research progress of IS related, including IS in CKD and its associated complications including chronic kidney disease, chronic kidney disease with cardiovascular disease, renal anemia, bone mineral metabolic disease and neuropsychiatric disorders, looking for IS accurate rapid detection methods, and explore the efficient treatment to reduce blood levels of indole phenol sulphate.

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Acknowledgements

We would like to express our gratitude to all those who helped us during the writing of this manuscript.

Funding

Foundation item: The project of introducing overseas students of Hebei province, C20210357, Yan Gao.

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  1. Yan Gao and Ye Li contributed equally to this study.

Authors and Affiliations

  1. Department of Nephrology, Affiliated Hospital of Hebei University, No. 212 Yuhuadonglu, Baoding, 071000, People’s Republic of China

    Yan Gao, Ye Li, Xueting Duan, Qian Wang & Haisong Zhang

  2. College of Clinical Medicine, Hebei University, No. 342 Yuhua Road, Baoding, 071000, People’s Republic of China

    Yan Gao, Ye Li, Xueting Duan, Qian Wang & Haisong Zhang

  3. Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, No. 212 Yuhuadonglu, Baoding, 071000, People’s Republic of China

    Yan Gao, Qian Wang & Haisong Zhang

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  1. Yan Gao
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YG and YL conceived of the study, and XD and QW participated in its design and Qian Wang helped to draft the manuscript. All authors read and approved the final manuscript.

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Correspondence to Qian Wang or Haisong Zhang.

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Gao, Y., Li, Y., Duan, X. et al. Research progress on the relationship between IS and kidney disease and its complications. Int Urol Nephrol 54, 2881–2890 (2022). https://doi.org/10.1007/s11255-022-03209-1

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