Abstract
Objective
To assess the testicular volume in children with unilateral cryptorchidism of different ages in Hainan Province, China.
Methods
The study included 424 children (ranging in age from 0 month to 4 years) with unilateral cryptorchidism or normal who were treated from 2017 to 2021 at our institution. They were divided into different groups according to age. We evaluated the correlation of testicular volume between the children with cryptorchidism and the normal children among different groups.
Results
There was a significant difference in testicular volume between the affected side and the healthy side. There was no difference in testicular volume between the left side and the right side of each control group. There were significant differences between the affected side of cryptorchid groups and the same side of the control groups. There were no significant differences between the healthy side of cryptorchid groups and the same side of the control groups. There were no significant differences between the affected side of left cryptorchid groups and right cryptorchid groups. There were no significant differences between the healthy side of left cryptorchid groups and right cryptorchid groups. There were significant differences in testicular volume among different age groups of the control group, while there were no differences in the cryptorchid groups.
Conclusions
The development of testicular volume in children with unilateral inguinal cryptorchidism is affected in earlier age, and there was no compensatory testicular adaptation in the healthy testis.
Similar content being viewed by others
References
Chung E, Brock GB (2011) Cryptorchidism and its impact on male fertility: a state of art review of current literature. Can Urol Assoc J 5(3):210–214
Sijstermans K, Hack WW, Meijer RW, van der Voort-Doedens LM (2008) The frequency of undescended testis from birth to adulthood: a review. Int J Androl 31(1):1–11. https://doi.org/10.1111/j.1365-2605.2007.00770.x
Huang J, Wang JY, Kong CZ, Li Hong, Xie Liping, Zhou Liqun, Ye Dingwei (2020). Guidelines for the diagnosis and treatment of benign disease of the scrotum and penis. In: Guidelines for diagnosis and treatment of urology and andrology in China, 2019. Beijing, China, pp 725–728.
Loebenstein M, Thorup J, Cortes D, Clasen-Linde E, Hutson JM, Li R (2020) Cryptorchidism, gonocyte development, and the risks of germ cell malignancy and infertility: a systematic review. J Pediatr Surg 55(7):1201–1210. https://doi.org/10.1016/j.jpedsurg.2019.06.023
Rübben I (2016) Cryptorchidism and fertility. Urologe A 55(7):890–897. https://doi.org/10.1007/s00120-016-0142-1
Goel P, Rawat JD, Wakhlu A, Kureel SN (2015) Undescended testicle: an update on fertility in cryptorchid men. Indian J Med Res 141(2):163–171
Spinelli C, Strambi S, Busetto M, Pucci V, Bianco F (2014) Effects on normalized testicular atrophy index (TAIn) in cryptorchid infants treated with GnRHa pre and post-operative vs surgery alone: a prospective randomized trial and long-term follow-up on 62 cases. Pediatr Surg Int 30(10):1061–1067. https://doi.org/10.1007/s00383-014-3577-8
Sarila G, Hutson JM, Vikraman J (2021) Testicular descent: a review of a complex, multistaged process to identify potential hidden causes of UDT. J Pediatr Surg. https://doi.org/10.1016/j.jpedsurg.2021.05.007
Sadov S, Koskenniemi JJ, Virtanen HE, Perheentupa A, Petersen JH, Skakkebaek NE, Main KM, Toppari J (2016) Testicular growth during puberty in boys with and without a history of congenital cryptorchidism. J Clin Endocrinol Metab 101(6):2570–2577. https://doi.org/10.1210/jc.2015-3329
Verkauskas G, Malcius D, Eidukaite A, Vilimas J, Dasevicius D, Bilius V, Hadziselimovic F (2016) Prospective study of histological and endocrine parameters of gonadal function in boys with cryptorchidism. J Pediatr Urol 12(4):238.e1-e6. https://doi.org/10.1016/j.jpurol.2016.05.007
Rosito NC, Koff WJ, da Silva Oliveira TL, Cerski CT, Salle JL (2004) Volumetric and histological findings in intra-abdominal testes before and after division of spermatic vessels. J Urol 171(6 Pt 1):2430–2433
Rodprasert W, Virtanen HE, Mäkelä JA, Toppari J (2020) Hypogonadism and cryptorchidism. Front Endocrinol (Lausanne) 10:906. https://doi.org/10.3389/fendo.2019.00906
Hadziselimovic F (2017) On the descent of the epididymo-testicular unit, cryptorchidism, and prevention of infertility. Basic Clin Androl 27:21. https://doi.org/10.1186/s12610-017-0065-8
Mieusset R, Fouda PJ, Vaysse P, Guitard J, Moscovici J, Juskiewenski S (1993) Increase in testicular temperature in case of cryptorchidism in boys. Fertil Steril 59(6):1319–1321. https://doi.org/10.1016/S0015-0282(16)55999-8
Takihara H, Cosentino MJ, Sakatoku J, Cockett AT (1987) Significance of testicular size measurement in andrology: II. Correlation of testicular size with testicular function. J Urol 137(3):416–419
Bahk JY, Jung JH, Jin LM, Min SK (2010) Cut-off value of testes volume in young adults and correlation among testes volume, body mass index, hormonal level, and seminal profiles. Urology 75(6):1318–1323. https://doi.org/10.1016/j.urology.2009.12.007
Spinelli C, Morelli G, Cito G, Bertocchini A, Ghionzoli M, Pucci A, Cocci A, Morganti R, Strambi S (2021) Correlation between testicular volume and histological findings in children with unilateral cryptorchidism: potential impact on future fertility. Urologia. https://doi.org/10.1177/03915603211004732
Koch T, Hansen AH, Priskorn L, Petersen JH, Carlsen E, Main KM, Skakkebaek NE, Jørgensen N (2020) A history of cryptorchidism is associated with impaired testicular function in early adulthood: a cross-sectional study of 6376 men from the general population. Hum Reprod 35(8):1765–1780. https://doi.org/10.1093/humrep/deaa127
Jedrzejewski G, Wozniak MM, Madej T, Kryza R, Zielonka-Lamparska E, Wieczorek AP (2012) The differences in testicular volumes in boys 8–36 months old with undescended, retractile and hydrocele testis–usefulness of scrotal screening ultrasound. Early Hum Dev 88(3):185–189. https://doi.org/10.1016/j.earlhumdev.2011.07.023
Jedrzejewski G, Wieczorek AP, Osemlak P, Nachulewicz P (2016) The role of ultrasound in the management of undescended testes before and after orchidopexy—an update. Medicine (Baltimore) 95(51):e5731
Al-Mendalawi MD (2020) Testicular Volume in a Cohort of Prepubertal Indian Children. J Indian Assoc Pediatr Surg, 25 (2):126. https://www.jiaps.com/text.asp?2020/25/2/126/276967
Zvizdic Z, Milisic E, Halimic A, Zvizdic D, Zubovic SV (2014) Testicular volume and testicular atrophy index as predictors of functionality of unilaterally cryptorchid testis. Med Arch 68(2):79–82
Shin J, Jeon GW (2020) Comparison of diagnostic and treatment guidelines for undescended testis. Clin Exp Pediatr 3(11):415–421. https://doi.org/10.3345/cep.2020.00115
Acknowledgements
This presented research was supported by Hainan Province Clinical Medical Center (QWYH202175).
Author information
Authors and Affiliations
Contributions
All authors contributed to the study conception and design. ZZ conceived the designed of the study and worked on the manuscript. SH drafted the original manuscript. ZW, WB and SC collected the data. YL provided critical comments of the manuscript. All authors approved the final version of the manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The author(s) declare that they have no conflict of interest.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent
Informed consent is not required due to the retrospective de-identified data set from the Inpatient Sample.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Hu, S., Zhao, Z., Wan, Z. et al. Comparative study of testicular volume in children with unilateral cryptorchidism of different ages in the tropical province of China. Int Urol Nephrol 54, 973–978 (2022). https://doi.org/10.1007/s11255-022-03171-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11255-022-03171-y