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Trends of primary glomerular disease in Turkey: TSN-GOLD registry report

  • Nephrology - Original Paper
  • Published:
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Abstract

Background

Although several renal biopsy registry reports have been published worldwide, there are no data on primary glomerular disease trends in Turkey.

Methods

Three thousand eight-hundred fifty-eight native kidney biopsy records were assessed in the Turkish Society of Nephrology Primary Glomerulopathy Working Group (TSN-GOLD) Registry. Secondary disease and transplant biopsies were not recorded in the registry. These records were divided into four periods, before 2009, 2009 to 2013, 2013–2017, and 2017–current.

Results

A total of 3858 patients (43.6% female, 6.8% elderly) were examined. Nephrotic syndrome was the most common biopsy indication in all periods (58.6%, 53%, 44.1%, 51.6%, respectively). In the whole cohort, IgA nephropathy (IgAN) (25.7%) was the most common PGN with male predominance (62.7%), and IgAN frequency steadily increased through the periods (× 2 = 198, p < 0.001). MGN was the most common nephropathy in the elderly (> 65 years), and there was no trend in this age group. An increasing trend was seen in the frequency of overweight patients (× 2 = 37, p < 0.0001). Although the biopsy rate performed with interventional radiology gradually increased, the mean glomeruli count in the samples did not change over the periods.

Conclusions

In Turkey, IgAN is the most common primary glomerulonephritis, and the frequency of this is increasing.

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Availability of data and material

All data are stored in an Excel file in the Turkish Society of Nephrology GOLD registration database. The registry web site address is: https://gold.nefroloji.org.tr.

Code availability

Not applicable.

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Acknowledgements

We would like to thank all our fellow nephropathologists for their never-ending efforts, contributions, and collaborations.

Funding

This study was financed by a grant from the Turkish Society of Nephrology.

Author information

Authors and Affiliations

  1. Department of Nephrology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey

    Cuma Bülent Gül & Nimet Aktaş

  2. Nephrology, Okmeydanı Training and Research Hospital, Istanbul, Turkey

    Mehmet Küçük & Başak Can

  3. Nephrology, Haseki Training and Resarch Hospital, Istanbul, Turkey

    Savaş Öztürk

  4. Nephrology, Istanbul University Medical School, Istanbul, Turkey

    Erol Demir

  5. Nephrology, Kocaeli University School of Medicine, Kocaeli, Turkey

    Necmi Eren

  6. Faculty of Medicine, Nephrology, Medipol University Hospital, Istanbul, Turkey

    Abdullah Şumnu

  7. Nephrology, Cerrahpasa University Medical School, Istanbul, Turkey

    Nurhan Seyahi

  8. Nephrology, Uludag University Medical Faculty Hospital, Bursa, Turkey

    Mustafa Güllülü

  9. Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey

    Fatih Dede

  10. Nephrology, Gazi University Medical Faculty, Ankara, Turkey

    Ülver Derici

  11. Nephrology, Sisli Hamidiye Training and Research Hospital, Istanbul, Turkey

    Yener Koç

  12. Nephrology, Osmangazi University, Odunpazarı, Eskisehir, Turkey

    Garip Şahin

  13. Nephrology, Erciyes University, Kayseri, Turkey

    Oktay Oymak

  14. Nephrology, Sultan Abdülhamid Han Training and Research Hospital, Istanbul, Turkey

    Gülizar Manga Sahin

  15. Nephrology, Bozyaka Training and Research Hospital, Izmir, Turkey

    Erhan Tatar

  16. Nephrology, Pamukkale University, Denizli, Turkey

    Belda Dursun

  17. Nephrology, Sakarya Training and Research Hospital, Sakarya, Turkey

    Hamad Dheir

  18. Istanbul Sadi Konuk Training and Research Hospital, Istanbul, Turkey

    Süheyla Apaydın

  19. Nephrology, Akdeniz University Hospital, Antalya, Turkey

    Gültekin Süleymanlar

  20. Nephrology, Afyon Kocatepe University Medical School, Afyonkarahisar, Turkey

    Sena Ulu

  21. Nephrology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey

    Orçun Altınören

  22. Faculty of Medicine, Nephrology, Ankara University, Ankara, Turkey

    Sim Kutlay

  23. Nephrology, Istanbul Dr Lufti Kirdar Kartal Training and Research Hospital, Istanbul, Turkey

    Meral Meşe

  24. Nephrology, Inonu University Medical School, Malatya, Turkey

    İdris Şahin

  25. Nephrology, Trakya University Medical School, Edirne, Turkey

    Sedat Üstündağ

  26. Nephrology, Necmettin Erbakan University Meram Medical School, Konya, Turkey

    Kültigin Türkmen & Nedim Yılmaz Selçuk

  27. Nephrology, Dicle University Medical School, Diyarbakir, Turkey

    Mehmet Emin Yılmaz

  28. Nephrology, Bezmialem University Medical School, Istanbul, Turkey

    Rümeyza Turan Kazancıoğlu

  29. Nephrology, Dokuz Eylul University Medical School, Izmir, Turkey

    Özcan Uzun & Caner Çavdar

  30. Nephrology, Cumhuriyet University Medical School, Sivas, Turkey

    Ferhan Candan

  31. Nephrology, Darıca Farabi Training and Research Hospital, Kocaeli, Turkey

    Zeki Aydın

  32. Nephrology, Lefkosa Burhan Nalbantoglu Hospital, Lefkosa, Turkish Republic of Northern Cyprus

    Deren Oygar

  33. Nephrology, Hacettepe University Medical School, Ankara, Turkey

    Yunus Erdem

  34. Nephrology, Cukurova University Medical School, Adana, Turkey

    Saime Paydaş

  35. Nephrology, Kocaeli State Hospital, Kocaeli, Turkey

    Dilek Taymez

  36. Nephrology, Mersin University Medical School, Mersin, Turkey

    Ahmet Kıykım

  37. Nephrology, Taksim Training and Research Hospital, Istanbul, Turkey

    Leyla Koç

  38. Nephrology, Baskent University Medical School, Ankara, Turkey

    Siren Sezer

  39. Nephrology, Ankara Atatürk Training and Research Hospital, Ankara, Turkey

    Murat Duranay

  40. Nephrology, Batman State Hospital, Batman, Turkey

    Simge Bardak

  41. Nephrology, Selcuk University Selcuklu Medical School, Konya, Turkey

    Lütfullah Altıntepe

  42. Nephrology, Marmara University Medical School, Istanbul, Turkey

    Burcu Kaya

  43. Nephrology, Balıkesir Training and Research Hospital, Balikesir, Turkey

    Alper Azak

  44. Nephrology, Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey

    Sebahat Alışır Ecder

Authors
  1. Cuma Bülent Gül
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  2. Mehmet Küçük
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  3. Savaş Öztürk
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  4. Erol Demir
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  5. Necmi Eren
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  6. Abdullah Şumnu
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  7. Nurhan Seyahi
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  8. Mustafa Güllülü
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  9. Fatih Dede
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  10. Ülver Derici
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  11. Yener Koç
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  15. Erhan Tatar
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  16. Belda Dursun
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  17. Hamad Dheir
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  18. Süheyla Apaydın
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  19. Gültekin Süleymanlar
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  20. Sena Ulu
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  22. Sim Kutlay
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  25. Sedat Üstündağ
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  26. Kültigin Türkmen
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  27. Mehmet Emin Yılmaz
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  28. Rümeyza Turan Kazancıoğlu
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  32. Deren Oygar
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  33. Nimet Aktaş
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  34. Yunus Erdem
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  35. Saime Paydaş
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  36. Dilek Taymez
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  37. Başak Can
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  38. Ahmet Kıykım
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  39. Leyla Koç
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  40. Siren Sezer
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  41. Murat Duranay
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  42. Simge Bardak
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  43. Lütfullah Altıntepe
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  44. Burcu Kaya
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  45. Alper Azak
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  46. Sebahat Alışır Ecder
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  47. Caner Çavdar
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  48. Nedim Yılmaz Selçuk
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Contributions

Dr. GUL and Dr. Ozturk wrote the manuscript, and all the other authors shared patient information at their center.

Corresponding author

Correspondence to Cuma Bülent Gül.

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Conflict of interest

All authors have no conflict of interests to declare.

Ethical approval

Ethical clearance was obtained from The Ethics Committee of Istanbul University, Istanbul Medical Faculty.

Consent to participate

Before kidney biopsy was performed, patient consent was obtained from the centers that entered data in the registry.

Consent for publication

The informed consent form contained the following warning: "Your data will be used in a clinical trial without personal information."

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Gül, C.B., Küçük, M., Öztürk, S. et al. Trends of primary glomerular disease in Turkey: TSN-GOLD registry report. Int Urol Nephrol 54, 2285–2294 (2022). https://doi.org/10.1007/s11255-022-03123-6

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