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Creatinine index as a predictive marker of sarcopenia in patients under hemodialysis

  • Nephrology - Original Paper
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Abstract

Purpose

Sarcopenia is a clinical condition that comprises declined skeletal muscle (SM) mass and SM strength, and is a risk factor for physical disability, impaired quality of life, and advanced morbidity and mortality in patients on hemodialysis (HD). The existing difficulty in evaluating SM mass and consequently of sarcopenia, with affordable and practical methods in clinical practice, is well established. The purpose of this study is to examine the creatinine index (CrI), a surrogate of SM mass, as a potential predictive marker of sarcopenia.

Methods

In this cross-sectional study, we included 130 patients on HD with a mean age of 66.17 ± 12.47 years. SM mass and SM strength were evaluated with CrI and hand grip strength, respectively. Anthropometric, adiposity, nutritional, and biochemical assessments were also performed. Partial correlation and multivariate regression analyses were applied to investigate the association between CrI and SM strength.

Results

Correlation analysis showed that mid-arm circumference, calf circumference, Geriatric nutritional index, and albumin-to-total protein ratio were positively associated with SM strength. Multivariate model indicated that CrI (β = 2.05, p < 0.001) and dialysis duration (β =− 0.53, p = 0.001) were independently related to SM strength. The significant positive correlation between CrI and SM strength remained unaffected even after adjusting for potential confounders.

Conclusions

Creatinine Index was significantly associated with SM strength highlighting its value as a new emerging practical in clinical setting sarcopenia predictive marker in HD patients.

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The data accessibility is warranted upon request.

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Funding

Authors received no funding for this study.

Author information

Authors and Affiliations

  1. Department of Nutrition, ‘‘Konstantopouleio’’ General Hospital of Athens, Athens, Greece

    Petrini Plytzanopoulou

  2. Dialysis Center, ‘‘Nefroiatriki’’, Athens, Greece

    Panagiotis Politis, Theodora Papachrysanthou & Christos Andriopoulos

  3. Department of Nephrology, ‘‘Henry Durant’’ Hospital Center, Athens, Greece

    Athina Drakou

  4. Department of Nephrology, University Hospital of Patras, Patras, Greece

    Evangelos Papachristou & Marios Papasotiriou

  5. Department of Surgery, ‘‘Konstantopouleio’’ General Hospital of Athens, Athens, Greece

    Miltiadis Papastamatiou

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  1. Petrini Plytzanopoulou
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  2. Panagiotis Politis
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  3. Theodora Papachrysanthou
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  4. Christos Andriopoulos
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  5. Athina Drakou
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  8. Marios Papasotiriou
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Contributions

All authors have contributed to the preparation of this manuscript. More specifically, PP designed, analyzed the data, and drafted the manuscript. PP, TP, CA, and AD were responsible for gathering the clinical data. EP, MP, and MP interpreted the data and revised the manuscript. All authors approved the final version of the article.

Corresponding author

Correspondence to Marios Papasotiriou.

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The authors declare that they have no conflict of interest related to this study.

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Ethical approval was obtained from the ethics committee of “Konstantopouleio” General Hospital, Athens, Greece.

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Informed consent was obtained from all individual participants included in the study.

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Plytzanopoulou, P., Politis, P., Papachrysanthou, T. et al. Creatinine index as a predictive marker of sarcopenia in patients under hemodialysis. Int Urol Nephrol 54, 1565–1573 (2022). https://doi.org/10.1007/s11255-021-03032-0

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