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Bladder augmentation from an insider’s perspective: a review of the literature on microcirculatory studies

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Abstract

Augmentation cystoplasty is an exemplary multiorgan intervention in urology which is particularly associated with microvascular damage. Our aim was to review the available intravital imaging techniques and data obtained from clinical and experimental microcirculatory studies involving the most important donor organs applied in bladder augmentation. Although numerous direct or indirect methods are available to assess the condition of microvessels the implementation of microcirculatory diagnostic methods in humans is still challenging and the assessment of organ microcirculation in the operating theatre has limitations. Nevertheless, preclinical studies generally report good internal validity and although prospective human protocols with reduced variability are needed, a possible positive impact of microcirculatory diagnostics on the clinical outcomes of urologic surgery can be anticipated.

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Acknowledgements

Gabriella Varga and Dániel Érces contributed equally to the paper. The study was supported by Economic Development and Innovation Operational Programme GINOP-2.3.2-15-2016-00034.

Funding

The study was supported by the Economic Development and Innovation Operational Programme GINOP-2.3.2-15-2016-00034.

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Authors and Affiliations

  1. Institute of Surgical Research, University of Szeged, Pulz u. 1., Szeged, 6724, Hungary

    Dániel Urbán, Tamás Cserni, Mihály Boros, Dániel Érces & Gabriella Varga

  2. Department of General and Thoracic Surgery, Hetényi Géza County Hospital, Tószegi u. 21., Szolnok, 5000, Hungary

    Dániel Urbán & Árpád Juhász

  3. Department of Paediatric Urology, The Royal Manchester Children’s Hospital, Oxford Road, Manchester, M13 9WL, UK

    Tamás Cserni

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  1. Dániel Urbán
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  2. Tamás Cserni
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  4. Árpád Juhász
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  5. Dániel Érces
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Contributions

DU wrote and edited the manuscript and did literature search; TC edited and critically revised the manuscript; MB did literature search and critically revised the manuscript; ÁJ critically revised the manuscript; DE wrote, edited and critically revised the manuscript; GV initiated the project, did literature search, wrote and critically revised the manuscript.

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Correspondence to Gabriella Varga.

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Urbán, D., Cserni, T., Boros, M. et al. Bladder augmentation from an insider’s perspective: a review of the literature on microcirculatory studies. Int Urol Nephrol 53, 2221–2230 (2021). https://doi.org/10.1007/s11255-021-02971-y

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