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Clinicopathological patterns of bladder carcinoma over 1 year: experience from University Hospital of Nepal

  • Urology - Original Paper
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Abstract

Purpose

To define the clinical and pathological patterns of urinary bladder carcinoma from the University Hospital of Nepal.

Methods

This is a retrospective analytical study. Patients with bladder mass who underwent surgery over 1 year and who had data record were included in the study. Demographic profile, type of surgery, findings on clinical examination, cystoscopy findings, histopathological report, tumor stage, and post-surgery adjuvant therapy were analyzed.

Results

Out of 86 patients who underwent transurethral resection of bladder tumor, 77 patients had biopsy-proven malignant bladder tumor. Urothelial cancer was present in 96.1%. Male were 78.6%. The mean age of diagnosis was 65.5 ± 11.8 years. Non-muscle-invasive bladder cancer (NMIBC) was 3.7 times more common than muscle-invasive bladder cancer (MIBC). High-grade tumors (58.6%) were more common than low grade (41.4%). The detrusor muscle was present inthe biopsy specimen of 48 patients (64%). Re-TURBT within 2–6 weeks was considered based on histopathology reports for about half of the patients (45.3%). Upstaging and upgrading of the tumor was present in 5.8 and 5.8% of the patients, respectively. Residual tumor without upstaging and upgrading was present in 23.5%. One patient (1.3%) had Clavien–Dindo grade 1, three (4%) patients had grade 2 and two patients (2.7%) had grade 3b.

Conclusion

In the present study, patients with bladder cancer are younger than reported in other studies. Smokers are strongly predisposed. The histological pattern is similar to the Western and Asian populations. NMIBC and MIBC occur in proportion to that described as in other studies. We had a lower rate of recurrence, upstaging and upgrading. We had a lesser rate of acceptance for radical cystectomy in our patients.

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Authors and Affiliations

  1. Department of Urology and Kidney Transplant Surgery, Tribhuvan University Teaching Hospital, Institute of Medicine, Maharajgunj, Kathmandu, 44600, Nepal

    Purushottam Parajuli, Bhoj Raj Luitel, Manish Man Pradhan, Suman Chapagain, Sujeet Poudyal, Sampanna Chudal, Bipin Guragain, Durga Pandit, Diwas Gnyawali, Prem Raj Sigdel, Pawan Raj Chalise & Uttam Kumar Sharma

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  1. Purushottam Parajuli
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Parajuli, P., Luitel, B.R., Pradhan, M.M. et al. Clinicopathological patterns of bladder carcinoma over 1 year: experience from University Hospital of Nepal. Int Urol Nephrol 53, 2289–2294 (2021). https://doi.org/10.1007/s11255-021-02969-6

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