Abstract
Background
Renal artery stenosis is caused by a heterogeneous group of diseases, including atherosclerosis and fibromuscular dysplasia, which can be treated medically, via endovascular techniques, or by open revascularization; however, satisfactory and effective results are not always obtained. We aimed to assess the possibility of renal revascularization by a pedicled intestinal segment wrapping the kidney.
Methods
Five dogs were operated on at three steps. At the first step, laparotomy was performed, and the right kidney was released. Subsequently, an 8–10 cm segment of jejunum was separated longitudinally, and mucosectomy was done. This intestinal patch wrapped up the kidney. After eight weeks, the kidney and the intestinal patch were analyzed, and the renal artery was ligated. After four weeks, the kidney and the intestinal patch were sent for pathological evaluation.
Results
At the 12th week of evaluation, no evidence of abscess formation or collection was seen. All kidneys had a normal color, consistency, and size. All renal cells were alive, and neither atrophy nor necrosis was seen. Glomerulus and tubules were intact, and no inflammatory change was visible. Furthermore, thick wall vasculature was inspected in a fibromuscular tissue, rising from the intestinal flap toward the kidney. One of the dogs expired due to peritonitis and sepsis in the fifth week.
Conclusion
In our study, indirect perfusion of the kidney by an intestinal patch was achieved successfully. This represents new hope in patients suffering from chronic renal failure who underwent former medical and surgical interventions with undesirable results.
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Data availability
All data regarding this study has been reported in the manuscript. If requiring any further details, please contact the corresponding author.
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HH: protocol development; SMM: project development; AH: project development; MA: pathological data collection; SS: data collection; KK: data collection; HH: manuscript editing; RS: project development; manuscript writing; data management.
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Hodjati, H., Moosavi, S.M., Hosseinzadeh, A. et al. Renal revascularization by a pedicled intestinal segment wrapping the kidney: a new method for kidney revascularization. Int Urol Nephrol 54, 257–262 (2022). https://doi.org/10.1007/s11255-021-02897-5
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DOI: https://doi.org/10.1007/s11255-021-02897-5