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Epidemiology of biopsy-proven glomerulonephritis in the past 25 years in the North-Eastern area of Romania

  • Nephrology - Original Paper
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The aim of this retrospective study was: to analyze the epidemiological patterns of the kidney disease based on clinical and histological features in a single-center in the N-E region of Romania, between 2011 and 2019 and to compare the biopsy results with the others periods, as well as the results from other countries.


We studied 442 renal biopsies. The indications for renal biopsy were represented by the clinical features: nephrotic syndrome, nephritic syndrome, asymptomatic urinary abnormalities, acute kidney injury, and chronic kidney disease of unknown etiology.


During the past 8 years, the annual incidence of renal biopsies was constant, albeit this incidence remained lower than in other countries. Nephrotic syndrome was the most common indication for renal biopsy (47.6%). Primary glomerulonephritis (GN) was the most common diagnosis in each of the three periods, followed by secondary GN. Vascular nephropathy and TIN were constant as a proportion from the overall biopsies in each of the three periods. The membranoproliferative GN (24.4%) and membranous nephropathy (MN) (21.9%) were the most prevalent primary GN, while lupus nephritis (LN) was the most common secondary glomerular disease in young female patients (7.5%). Compared to 1994–2004 period, we observed a significant decrease of incidence of focal segmental glomerulosclerosis (FSGS) and mesangial proliferative GN, and a significant increases in the frequency of MN.


The results of this study show that the GN distribution model was constant in N-E Romania and became similar to that observed in many countries with high socio-economic status.

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Availability of data and material

The data and material of this study are available from the author (L.F.) on reasonable request.


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AC: was supported by a grant of Ministry of Research and Innovation, CNCS—UEFISCDI, project number PN-III-P4-ID-PCE-2016-0908, contract number 167/2017, within PNCDI III.

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CEV, AC analyzed and interpreted the patients’ data regarding the inclusion criteria. LF, LV, SH, SC performed the clinical examination during all three periods. AC performed the renal biopsy during all three periods. IDC performed the histological examination during all three periods. All authors read and approved the final manuscript.

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Correspondence to Cristiana-Elena Vlad.

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Covic, A., Vlad, CE., Căruntu, ID. et al. Epidemiology of biopsy-proven glomerulonephritis in the past 25 years in the North-Eastern area of Romania. Int Urol Nephrol 54, 365–376 (2022).

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