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Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease

  • Nephrology - Original Paper
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Abstract

Purpose

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease and the majority of patients have a PKD-1 or PKD-2 mutation. Sirtuin 1 (SIRT1) has roles in cellular aging, antioxidant activity, cellular proliferation. In an experimental study, inhibition of SIRT1 was found to delay renal cyst development in ADPKD. The purpose of this study is to determine the SIRT1 levels in ADPKD patients. To our knowledge, this is the first study that investigating blood and urine SIRT1 levels in ADPKD patients.

Methods

Sixty-seven patients with ADPKD and 34 control cases with normal renal functions and without renal cysts were included in this study. Serum and urine SIRT1 concentrations were determined by human enzyme-linked immunosorbent assay (ELISA) kit. 24-h urine samples were used for urine SIRT1 measurements.

Results

The urine SIRT1 levels were statistically significantly lower in ADPKD patients group (p < 0.001). Although blood SIRT1 levels of ADPKD patients were higher than control cases but there were no statistically significant difference between the groups in terms of blood SIRT1 levels. Urine SIRT1 levels (β = 2.452, CI 95% 1.419–4.239, p = 0.001) were found an independent factor in multivariate regression analysis for ADPKD.

Conclusions

Urine SIRT1 levels were lower in ADPKD patients than control group. The low urinary SIRT1 levels despite the similar blood SIRT1 levels might be due to the impaired metabolism of SIRT1 in ADPKD patients; this state might has a role in cyst development.

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Authors and Affiliations

  1. Division of Nephrology, Department of Internal Medicine, Konya Training and Research Hospital, University of Health Sciences, Konya, Turkey

    Pervin Ozkan Kurtgoz, Suleyman Karakose, Edip Erkus & Ibrahim Guney

  2. Department of Medical Biochemistry, Konya Training and Research Hospital, University of Health Sciences Turkey, Konya, Turkey

    Cigdem Damla Cetinkaya

Authors
  1. Pervin Ozkan Kurtgoz
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  2. Suleyman Karakose
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  3. Cigdem Damla Cetinkaya
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  4. Edip Erkus
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  5. Ibrahim Guney
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Corresponding author

Correspondence to Pervin Ozkan Kurtgoz.

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Ethical approvement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee at which the studies were conducted and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was accepted (Decision number 41901325-050.99) by the Ethics Committee of Karatay University. Signed informed consent form was taken from all patients and control cases.

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The authors declare that they have no conflict of interest.

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Informed consent was obtained from all individual participants included in the study.

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Ozkan Kurtgoz, P., Karakose, S., Cetinkaya, C.D. et al. Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease. Int Urol Nephrol 54, 131–135 (2022). https://doi.org/10.1007/s11255-021-02862-2

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  • DOI: https://doi.org/10.1007/s11255-021-02862-2

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