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Impact of small and dense low-density lipoprotein (sd-LDL)on contrast-induced acute kidney injury in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

  • Nephrology - Original Paper
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Abstract

Objective

To investigate the impact of serum small and dense low-density lipoprotein (sd-LDL) on contrast-induced acute kidney injury (CI-AKI) after emergency percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI).

Method

From November 2019 to August 2020, 352 patients with STEMI who underwent primary PCI were recruited consecutively. Patients were divided into CI-AKI group (n = 71) and non-CI-AKI group (n = 281). CI-AKI was defined as an increase in serum creatinine (≥ 25% or ≥ 0.5 mg/dL) from baseline occurring 72 h after PCI. All subjects were tested for sd-LDL.

Results

In the 352 eligible patients with STEMI receiving emergency PCI, 71 patients (20.2%) developed CI-AKI. The levels of sd-LDL in CI-AKI group was higher than those in the non-CI-AKI group, and the difference was statistically significant (P < 0.05). The area under the curve (AUC) of the sd-LDL was 0.741 [95% confidence interval (CI) 0.538–0.636] in the STEMI patients receiving emergency PCI. CI-AKI model included the following five predictors: sd-LDL, NLR, Diabetes, Pre-PCI eGFR, and Log NT-proBNP. The AUC of forecast probability was 0.835 [95% confidence interval (CI) 0.786–0.883].The Hosmer–Lemeshow test has a P value of 0.519, which confirms the model’s goodness of fit.

Conclusion

Increased sd-LDL is independently associated with risk of CI-AKI in STEMI patients treated by primary PCI.

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Funding

The author(s) received no financial support for the research, authorship, and/or publication of this article.

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Author notes

  1. Yuhan Li and Kai Ma contributed equally to this work.

Authors and Affiliations

  1. Institute of Cardiovascular Diseases, Xuzhou Medical University, Xuzhou, 221000, China

    Yuhan Li, Kai Ma, Guoqi Shen & Wenhua Li

  2. Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Xuzhou, 221002, Jiangsu, China

    Di Zheng, Yongli Xuan & Wenhua Li

Authors
  1. Yuhan Li
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  2. Kai Ma
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  3. Guoqi Shen
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  4. Di Zheng
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  5. Yongli Xuan
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  6. Wenhua Li
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Contributions

YL, KM and WL contributed in the conception of the work, conducting the study, revising the draft, approval of the final version of the manuscript, and agreed for all aspects of the work. YL, KM, GS, DZ, YX and WL contributed in the conception of the work, drafting and revising the draft. All authors read and approved the final version of the manuscript.

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Correspondence to Wenhua Li.

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Li, Y., Ma, K., Shen, G. et al. Impact of small and dense low-density lipoprotein (sd-LDL)on contrast-induced acute kidney injury in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Int Urol Nephrol 53, 2611–2617 (2021). https://doi.org/10.1007/s11255-021-02821-x

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  • DOI: https://doi.org/10.1007/s11255-021-02821-x

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