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Adult primary nephrotic syndrome trends by race: a diminished frequency of focal segmental glomerulosclerosis in non-black patients

  • Nephrology - Original Paper
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Abstract

Purpose

There have been conflicting data on the relative frequency of common forms of primary nephrotic syndrome (PNS). We undertook this study to look at the causes of PNS in the latest decade from our biopsy population, with a special attention to breakdown by race.

Methods

Retrospective chart review of all cases of adult PNS extracted from a database of 1388 cases for the last 10 years. We were careful to exclude patients with secondary disease and without the full nephrotic syndrome.

Results

There were 115 cases of PNS. Overall, MN was the most common lesion (40.0%), followed by minimal change disease (MCD) (34.0%), focal segmental glomerulosclerosis (FSGS) (13.0%), and IgA nephropathy (IgAN) (11.3%). Among whites, MN was the most common cause of NS (41.7%), followed by MCD (33.3%), IgAN (16.7%), and FSGS (6.3%). Among blacks, FSGS was the most common lesion (33.3%) followed closely by MN (29.6%), and MCD (26.0%). IgAN was present in 7.4%. Among multiracial patients (MR), MGN was the most common (50%) followed by MCD (45.5%) and FSGS (4.5%). In Asians, MCD (50.1%) and MGN (33.3%) were the most common, followed by FSGS and IgAN with 8.3% each.

Conclusions

MN and MCD were the most common causes of PNS in our population, with FSGS much less common overall. This is especially the case among whites and MR. Among blacks, MN and FSGS were almost codominant causes. The apparent decreased prevalence of FSGS may be related to more effective exclusion of secondary and maladaptive causes.

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Acknowledgements

We thank Kaveh Hajifathalian MD, MPH for assistance with statistical analysis.

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Authors and Affiliations

  1. Division of Nephrology at Lenox Hill Hospital, Long Island Jewish Medical, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA

    Corinne Mbakop, Maria V. DeVita & Jordan L. Rosenstock

  2. Department of Pathology at Lenox Hill Hospital, Long Island Jewish Medical, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA

    Samuel J. Wahl

  3. Department of Pathology at North Shore University Hospital, Long Island Jewish Medical, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA

    Vanesa Bijol

Authors
  1. Corinne Mbakop
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  2. Maria V. DeVita
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  3. Samuel J. Wahl
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  4. Vanesa Bijol
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  5. Jordan L. Rosenstock
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Correspondence to Corinne Mbakop.

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Mbakop, C., DeVita, M.V., Wahl, S.J. et al. Adult primary nephrotic syndrome trends by race: a diminished frequency of focal segmental glomerulosclerosis in non-black patients. Int Urol Nephrol 53, 719–724 (2021). https://doi.org/10.1007/s11255-020-02658-w

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  • DOI: https://doi.org/10.1007/s11255-020-02658-w

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