Abstract
Aim
The aim of this study was to explore the effect of sex on the clinicopathological features and long-term outcomes of IgAN patients.
Methods
A total of 1096 adult IgAN patients were divided into male and female groups. Clinicopathological features and risk factors of IgAN patients of different genders were contrasted. The primary endpoint was the combined endpoint of a 50% reduction in estimated glomerular filtration rate (eGFR) and/or end stage renal disease (ESRD: eGFR < 15 mL/min/1.73 m2 or dialysis). The effect of gender on prognosis of IgAN was assessed using Kaplan–Meier and Cox proportional hazards models.
Results
In total, 475 male patients and 621 female patients were included in this study. At baseline, male patients had higher values for blood pressure, serum creatinine, urine protein and serum uric acid, as well as lower levels of eGFR. Further analysis indicated that tubular atrophy/interstitial fibrosis (T) lesions and vascular lesions were more frequent in male patients. During the follow-up period of 40.9 ± 24.2 months, kidney survival rates of male IgAN patients were remarkably lower than those of female patients. Using multivariate Cox regression analysis, male gender was identified as an independent risk factor for poor outcomes (β = 0.384, Wald = 4.290, Exp (β) = 1.47, p = 0.038), including hypertension, low eGFR, IgM deposition, arteriosclerosis lesions and T1–T2 lesions. However, male and female patients were characterized by different risk factors.
Conclusion
Male patients presented with more severe clinical and pathological changes than female patients. Renal survival rates of male patients were remarkably lower than those of female patients, and male gender was identified as an independent risk factor for poor outcomes.
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References
Lai KN, Tang SC, Schena FP et al (2016) IgA nephropathy[J]. Nat Rev Dis Prim 2:16001
Rodrigues JC, Haas M, Reich HN (2017) IgA Nephropathy[J]. Clin J Am Soc Nephrol 12(4):677–686
Goto M, Wakai K, Kawamura T et al (2009) A scoring system to predict renal outcome in IgA nephropathy: a nationwide 10-year prospective cohort study[J]. Nephrol Dial Transplant 24(10):3068–3074
Donadio JV, Bergstralh EJ, Grande JP et al (2002) Proteinuria patterns and their association with subsequent end-stage renal disease in IgA nephropathy[J]. Nephrol Dial Transplant 17(7):1197–1203
Xie J, Lv J, Wang W et al (2018) Kidney failure risk prediction equations in IgA nephropathy: a multicenter risk assessment study in Chinese patients[j]. Am J Kidney Dis 72(3):371–380
Moriyama T, Tanaka K, Iwasaki C et al (2014) Prognosis in IgA nephropathy: 30-year analysis of 1012 patients at a single center in Japan[J]. PLoS ONE 9(3):e91756
Neugarten J, Acharya A, Silbiger SR (2000) Effect of gender on the progression of nondiabetic renal disease: a meta-analysis[J]. J Am Soc Nephrol 11(2):319
Deng W, Tan X, Zhou Q et al (2018) Gender-related differences in clinicopathological characteristics and renal outcomes of Chinese patients with IgA nephropathy[J]. BMC Nephrol 19(1):31
Cattran DC, Reich HN, Beanlands HJ et al (2008) The impact of sex in primary glomerulonephritis[J]. Nephrol Dial Transplant 23(7):2247–2253
Levey AS, Stevens LA, Schmid CH et al (2009) A new equation to estimate glomerular filtration rate[J]. Ann Intern Med 150(9):604–612
Trimarchi H, Barratt J, Cattran DC et al (2017) Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group[J]. Kidney Int 91(5):1014–1021
Peng W, Tang Y, Tan L et al (2019) Crescents and global glomerulosclerosis in Chinese IgA nephropathy patients: a 5-year follow-up[J]. Kidney Blood Press Res 44(1):103–112
Kurahashi H, Watanabe M, Sugimoto M et al (2013) Testosterone replacement elevates the serum uric acid levels in patients with female to male gender identity disorder[J]. Endocr J 60(12):1321–1327
Barbour SJ, Cattran DC, Kim SJ et al (2013) Individuals of Pacific Asian origin with IgA nephropathy have an increased risk of progression to end-stage renal disease[J]. Kidney Int 84(5):1017–1024
Knoop T, Vikse BE, Svarstad E et al (2013) Mortality in patients with IgA nephropathy[J]. Am J Kidney Dis 62(5):883–890
Jarrick S, Lundberg S, Welander A et al (2017) Clinical validation of immunoglobulin A nephropathy diagnosis in Swedish biopsy registers[J]. Clin Epidemiol 9:67–73
O'Shaughnessy MM, Hogan SL, Thompson BD et al (2018) Glomerular disease frequencies by race, sex and region: results from the International Kidney Biopsy Survey[J]. Nephrol Dial Transplant 33(4):661–669
Reckelhoff JF (2018) Gender differences in hypertension[J]. Curr Opin Nephrol Hypertens 27(3):176–181
Matsukuma Y, Masutani K, Tanaka S et al (2017) A J-shaped association between serum uric acid levels and poor renal survival in female patients with IgA nephropathy[J]. Hypertens Res 40(3):291–297
Tan M, Li W, Zou G et al (2015) Clinicopathological features and outcomes of IgA nephropathy with hematuria and/or minimal proteinuria[J]. Kidney Blood Press Res 40(2):200–206
Yamamoto R, Nagasawa Y, Shoji T et al (2010) Cigarette smoking and progression of IgA nephropathy[J]. Am J Kidney Dis 56(2):313–324
Beck L, Bomback AS, Choi MJ et al (2013) KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis[J]. Am J Kidney Dis 62(3):403–441
Riispere Ž, Laurinavičius A, Kuudeberg A et al (2016) IgA nephropathy clinicopathologic study following the Oxford classification: progression peculiarities and gender-related differences[J]. Medicina 52(6):340–348
Tan L, Tang Y, Peng W et al (2018) Combined immunosuppressive treatment may improve short-term renal outcomes in Chinese patients with advanced IgA nephropathy[J]. Kidney Blood Press Res 43(4):1333–1343
Coppo R, Troyanov S, Bellur S et al (2014) Validation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments[J]. Kidney Int 86(4):828–836
Zhang Y, Sun L, Zhou S et al (2018) Intrarenal arterial lesions are associated with higher blood pressure, reduced renal function and poorer renal outcomes in patients with IgA nephropathy[J]. Kidney Blood Press Res 43(2):639–650
Rauen T, Eitner F, Fitzner C et al (2015) Intensive supportive care plus immunosuppression in IgA nephropathy[J]. N Engl J Med 373(23):2225–2236
Carrero JJ, Hecking M, Chesnaye NC et al (2018) Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease[J]. Nat Rev Nephrol 14(3):151–164
Seppi T, Prajczer S, Dorler MM et al (2016) Sex differences in renal proximal tubular cell homeostasis[J]. J Am Soc Nephrol 27(10):3051–3062
Chakera A, MacEwen C, Bellur SS et al (2016) Prognostic value of endocapillary hypercellularity in IgA nephropathy patients with no immunosuppression[J]. J Nephrol 29(3):367–375
Sevillano AM, Gutierrez E, Yuste C et al (2017) Remission of hematuria improves renal survival in IgA nephropathy[J]. J Am Soc Nephrol 28(10):3089–3099
Heybeli C, Oktan MA, Yildiz S et al (2019) Clinical significance of mesangial IgM deposition in patients with IgA nephropathy[J]. Clin Exp Nephrol 23(3):371–379
Acknowledgements
This study was partially supported by the National Natural Science Foundation of China (no. 81270793) and the Science and Technology Planning Project of Sichuan Province (no. 2019YFS0280). We thank all of our colleagues at West China Hospital of Sichuan University for their excellent data collection.
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Wen, D., Tang, Y., Tan, L. et al. Sex disparities in IgA nephropathy: a retrospective study in Chinese patients. Int Urol Nephrol 53, 315–323 (2021). https://doi.org/10.1007/s11255-020-02631-7
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DOI: https://doi.org/10.1007/s11255-020-02631-7