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Regional brain atrophy in overactive bladder syndrome: a voxel based morphometry study

  • Urology - Original Paper
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Abstract

Objectives

To investigate whether patients with overactive bladder syndrome (OAB) have brain volume changes using voxel-based morphometry (VBM) and correlations with clinical tests.

Methods

With institutional review board approval and after obtaining written informed consent, structural magnetic resonance imaging data were prospectively acquired in 28 patients and 28 control subjects. OAB symptoms were assessed using the OAB symptom score (OABSS) scale. The gray matter volume (GMV) of each voxel was compared between the two groups while controlling for the effects of age, sex, and education level. Correlation analysis was performed to identify correlations between abnormal GMV regions and OABSS scores in patients. Multiple comparisons were corrected using a false discovery rate (FDR) method.

Results

Patients with OAB exhibited a GMV reduction in the right cerebellum, bilateral hippocampus, left insula, right superior temporal gyrus, left anterior cingulate gyrus, bilateral caudate nucleus and right middle frontal gyrus. Furthermore, there was a significant negative correlation between the local GMV of the right cerebellar hemisphere and OABSS score.

Conclusions

Patients with OAB have abnormal GMV in brain regions localized within the brain-bladder control network. It deepens our understanding of the structural changes in the brain area of the network. The patterns of structural reorganization in patients with OAB may provide useful information in the neuropathological mechanisms of the OAB.

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References

  1. Smith AL (2018) Understanding overactive bladder and urgency incontinence: what does the brain have to do with it? F1000 Research 7:1869

    Article  Google Scholar 

  2. Kitta T, Mitsui T, Kanno Y, Chiba H, Moriya K, Shinohara N (2015) Brain-bladder control network: The unsolved 21st century urological mystery. Int J Urol 22(4):342–348

    Article  PubMed  Google Scholar 

  3. Ridgway GR, Henley S, Rohrer JD, Scahill RI, Warren JD, Fox NC (2008) Ten simple rules for reporting voxel-based morphometry studies. NeuroImage 40(4):1429–1435

    Article  PubMed  Google Scholar 

  4. Homma Y, Yoshida M, Seki N, Yokoyama O, Kakizaki H, Gotoh M, Yamanishi T, Yamaguchi O, Takeda M, Nishizawa O (2006) Symptom assessment tool for overactive bladder syndrome–overactive bladder symptom score. Urology 68(2):318–323. https://doi.org/10.1016/j.urology.2006.02.042

    Article  PubMed  Google Scholar 

  5. Sepehry AA (2014) Self-rating depression scale (SDS). Springer, New York

    Book  Google Scholar 

  6. Wang W (2011) Confirmatory factor analysis of the Zung self-rating Anxiety Scale. Chin J Health Psychol 19:781–782

    Google Scholar 

  7. Mahendran R, Chua J, Feng L, Kua EH, Preedy VR (2015) the mini-mental state examination and other neuropsychological assessment tools for detecting cognitive decline. Elsevier Inc., Amsterdam

    Book  Google Scholar 

  8. Manto M, Nordeyn OBT (2013) The Contributions of the cerebellum in sensorimotor control: what are the prevailing opinions which will guide forthcoming studies? Cerebellum 12(3):313–315

    Article  PubMed  Google Scholar 

  9. Huang TF, Yang CP, Yang SL (1979) The role of the fastigial nucleus in bladder control. Exp Neurol 66(3):681

    Article  Google Scholar 

  10. Lars M, Bertil FMB, Flavia G, Michael K, Brigitte S, Kurtz M, Spyros K, Ulrich M (2014) Supraspinal control of urine storage and micturition in men—an fMRI Study. Cereb Cortex 25(10):10

    Google Scholar 

  11. Nardulli R, Monitillo V, Losavio E, Fiore P, Megna G (1992) Urodynamic evaluation of 12 ataxic subjects: neurophysiopathologic considerations. Funct Neurol 7(3):223–225

    CAS  PubMed  Google Scholar 

  12. Stevens FL, Hurley RA, Taber KH (2011) Anterior cingulate cortex: unique role in cognition and emotion. J Neuropsychiatry Clin Neurosci 23(2):121–125

    Article  PubMed  Google Scholar 

  13. Arienzo D, Babiloni C, Ferretti A, Caulo M, Gratta CD, Tartaro A, Rossini PM, Romani GL (2006) Somatotopy of anterior cingulate cortex (ACC) and supplementary motor area (SMA) for electric stimulation of the median and tibial nerves: an fMRI study. NeuroImage 33(2):700–705

    Article  CAS  PubMed  Google Scholar 

  14. Griffiths D, Tadic SD (2007) Bladder control, urgency, and urge incontinence: Evidence from functional brain imaging. Neurourol Urodyn 27(6):466–474

    Article  Google Scholar 

  15. Critchley HD, Wiens S, Rotshtein P, Öhman A, Dolan RJ (2004) Neural systems supporting interoceptive awareness. Nat Neurosci 7(2):189–195

    Article  CAS  PubMed  Google Scholar 

  16. Komesu YM, Ketai LH, Mayer AR, Teshiba TM, Rogers RG (2011) Functional magnetic resonance imaging of the brain in women with overactive bladder: brain activation during urinary urgency. Female Pelvic Med Reconstr Surg 17(1):50–54

    Article  PubMed  PubMed Central  Google Scholar 

  17. Tai C, Wang J, Jin T, Wang P, Kim SG, Roppolo JR, de Groat WC (2009) Brain switch for reflex micturition control detected by FMRI in rats. J Neurophysiol 102(5):2719–2730. https://doi.org/10.1152/jn.00700.2009

    Article  PubMed  PubMed Central  Google Scholar 

  18. Matsuura S, Kakizaki H, Mitsui T, Shiga T, Koyanagi T (2002) Human brain region response to distention or cold stimulation of the bladder: a positron emission tomography study. J Urol 168(5):2035–2039

    Article  PubMed  Google Scholar 

  19. Yamamoto T, Sakakibara R, Nakazawa K, Uchiyama T, Shimizu E, Hattori T (2009) Effects of electrical stimulation of the striatum on bladder activity in cats. Neurourol Urodyn 28(6):549–554

    Article  PubMed  Google Scholar 

  20. Yau Y, Dadar M, Taylor M, Zeighami Y, Fellows LK, Cisek P, Dagher A (2019) Neural correlates of evidence and urgency during human perceptual decision-making in dynamically changing conditions. bioRxiv:84775. https://doi.org/10.1101/847756

    Article  Google Scholar 

  21. Zhang H, Reitz A, Kollias S, Summers P, Curt A, Schurch B (2005) An fMRI study of the role of suprapontine brain structures in the voluntary voiding control induced by pelvic floor contraction. NeuroImage 24(1):174–180

    Article  PubMed  Google Scholar 

  22. National Clinical Guideline C (2012) National Institute for Health and Clinical Excellence: Guidance. In: Urinary Incontinence in neurological disease: management of lower urinary tract dysfunction in neurological disease. Royal College of Physicians (UK), National Clinical Guideline Centre, London. https://www.ncbi.nlm.nih.gov/books/NBK132831/pdf/Bookshelf_NBK132831.pdf

  23. Porter AB, Healy L, Foster NL, Josephs KA (2007) Compulsive urination as a presenting symptom of frontotemporal dementia. Eur J Neurol 14(8):e16–17. https://doi.org/10.1111/j.1468-1331.2007.01864.x

    Article  CAS  PubMed  Google Scholar 

  24. Jang HJ, Kwon MJ, Cho KO (2018) Central regulation of micturition and its association with epilepsy. Int Neurol J 22(1):2–8. https://doi.org/10.5213/inj.1836040.020

    Article  Google Scholar 

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Funding

This study was supported by grants from the National Nature Science Foundation of China (No. Grant nos. 81541129, 81301016, KZ73100001) and the Beihang University Research Fund Program under Project ZG216S1871.

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Authors and Affiliations

  1. Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China

    Long Zuo, Yang Zhou, Shuangkun Wang & Hua Gu

  2. Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

    Biao Wang

  3. School of Economics and Management, Beihang University, Beijing, China

    Jingnan Chen

Authors
  1. Long Zuo
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  2. Yang Zhou
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  3. Shuangkun Wang
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  4. Biao Wang
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  5. Hua Gu
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  6. Jingnan Chen
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Corresponding author

Correspondence to Shuangkun Wang.

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Conflicts of interest

None of the contributing authors have any conflict of interest, including specific financial interests or relationships and affiliations relevant to the subject matter or materials discussed in the manuscript.

Informed consent

All patients have provided informed consent.

Research involving human participants

This study was approved by the Committee for Human Research in Beijing Chaoyang Hospital and followed by all regulations (Grant nos. 2015-ke-21).

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Cite this article

Zuo, L., Zhou, Y., Wang, S. et al. Regional brain atrophy in overactive bladder syndrome: a voxel based morphometry study. Int Urol Nephrol 53, 27–33 (2021). https://doi.org/10.1007/s11255-020-02614-8

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  • DOI: https://doi.org/10.1007/s11255-020-02614-8

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