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Decreased insulin-like growth factor-1 (IGF-1) concentration correlates with reduced left-ventricle ejection fraction (LVEF) in hemodialysis patients

  • Nephrology - Original Paper
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Abstract

Purpose

The main purpose of this study is to determine the correlation between the serum IGF-1 concentration and certain cardiac indexes in hemodialysis patients.

Methods

The study was conducted at the Clinical Center of Montenegro and three regional hemodialysis centers. The echocardiographic studies were performed the day after the hemodialysis sessions. Blood samples were taken before dialysis for the measurement of IGF1 and PTH.

Results

A total of 102 patients were divided into two groups according to their left-ventricular ejection fraction (EF). Patients in the group with the higher EF had higher IGF-1 concentration (p = 0.024). IGF-1 was positively correlated with EF (ρ = 0.251, p = 0.012), and negatively correlated with LVMI (ρ = − 0.621, p < 0.001), SW (ρ = − 0.632, p < 0.001), and LW (ρ = − 0.632, p < 0.001). Multiple linear regression analysis was performed to determine the possible independent association between the EF and IGF-1 and the clinical data. The age of patients, their gender, and smoking habits did not have any combined influence on EF, but IGF-1 had a strong influence and was independently associated with the ejection fraction.

Conclusion

Our results may indicate the possible protective role of IGF-1 in the maintenance of heart structure and function in hemodialysis patients.

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Acknowledgements

This research was supported by the technical and medical staff of the Clinic for Nephrology and the Centre for Laboratory Diagnostic of the Clinical Centre of Montenegro.

Funding

There are no grants or other funding for the conducted survey.

Author information

Authors and Affiliations

  1. Clinic for Nephrology, Clinical Center of Montenegro, Ljubljanska bb, 81000, Podgorica, Montenegro

    Vladimir Prelevic, Danilo Radunovic, Branka Gledovic & Marina Ratkovic

  2. Center for Clinical-Laboratory Diagnostics, Clinical Centre of Montenegro, Ljubljanska bb, Podgorica, 81000, Montenegro

    Tanja Antunovic & Najdana Gligorovic Barhanovic

  3. Clinic for Heart Disease, Clinical Centre of Montenegro, Ljubljanska bb, Podgorica, 81000, Montenegro

    Nebojsa Bulatovic

  4. Department of Nephrology, Arterial Hypertension, Dialysis and Kidney Transplantation, Clinic for Internal Medicine, University Clinical Hospital Centre Zagreb, Kispaticeva 12, Zagreb, 10000, Croatia

    Nikolina Basic-Jukic

Authors
  1. Vladimir Prelevic
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  2. Tanja Antunovic
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  3. Danilo Radunovic
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  4. Najdana Gligorovic Barhanovic
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  5. Branka Gledovic
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  6. Nebojsa Bulatovic
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  7. Marina Ratkovic
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  8. Nikolina Basic-Jukic
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Corresponding author

Correspondence to Vladimir Prelevic.

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Conflict of interest

All authors declare no conflict of interests.

Ethics approval

This study was approved by the Ethical Committee of the Clinical Centre of Montenegro, and was performed in accordance with the relevant ethical standards and the Declaration of Helsinki.

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All patients gave their informed consent to participate in the study.

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Cite this article

Prelevic, V., Antunovic, T., Radunovic, D. et al. Decreased insulin-like growth factor-1 (IGF-1) concentration correlates with reduced left-ventricle ejection fraction (LVEF) in hemodialysis patients. Int Urol Nephrol 52, 2385–2391 (2020). https://doi.org/10.1007/s11255-020-02595-8

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  • DOI: https://doi.org/10.1007/s11255-020-02595-8

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