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The association of the decline in glomerular filtration rate with aggressive endometrial cancers

  • Nephrology - Original Paper
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Abstract

Purpose

Most site-specific cancer incidence is increased with the decrease of glomerular filtration rate (GFR). We analyzed endometrial cancers depending on different type, staging, and histology grades. We hypothesized that patients with lower GFR levels have an increased risk for higher staging and histology grades of endometrial cancers.

Methods

Patients were divided into two subgroups regarding GFR; the first group with GFR < 60 ml/min and the second group with GFR > 60 ml/min and regarding different histology grades and cancer stages. Cancers were also divided by stages (1–4). Patients were followed up during 1 year through regular controls in the outpatient clinic and during that time cancer recurrence was recorded.

Results

GFR was the strongest predictor for higher cancer histology grade and higher cancer staging. Patients with reduced GFR had OR for higher histology grade and higher staging of 1.06 and 1.06. Traditional risk factors for endometrial cancer development were not associated with higher histology grade or higher cancer staging.

Conclusion

Higher staging and histology grades in patients with endometrial cancers are associated with reduced GFR. Patients with mild-to-moderate CKD had significantly higher number of cancers with higher histology grades and higher stages than patients with mild or normal GFR category. Decline in GFR was independently associated with more aggressive cancers without other well-known risk factors for endometrial cancer development like age, menopause, diabetes, and obesity.

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Authors and Affiliations

  1. Department of Nephrology Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, Kispaticeva 12, 10 000, Zagreb, Croatia

    Vedran Premuzic

  2. Department of Gynecology and Obstetrics, Clinical Hospital “Sveti Duh”, Sveti Duh 64, 10 000, Zagreb, Croatia

    Egon Kruezi, Matea Berovic, Ingrid Marton & Dubravko Habek

  3. Department of Gynecology and Obstetrics, University Hospital Centre “Sestre Milosrdnice”, Vinogradska Cesta 29, 10 000, Zagreb, Croatia

    Lana Leko, Lucija Susnjar & Drazan Butorac

Authors
  1. Vedran Premuzic
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  2. Egon Kruezi
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  3. Matea Berovic
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  4. Lana Leko
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  5. Lucija Susnjar
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  6. Ingrid Marton
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  7. Drazan Butorac
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  8. Dubravko Habek
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Correspondence to Vedran Premuzic.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Premuzic, V., Kruezi, E., Berovic, M. et al. The association of the decline in glomerular filtration rate with aggressive endometrial cancers. Int Urol Nephrol 52, 161–168 (2020). https://doi.org/10.1007/s11255-019-02324-w

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  • DOI: https://doi.org/10.1007/s11255-019-02324-w

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