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Clinical characteristics and outcomes of robot-assisted laparoscopic radical prostatectomy in HIV-positive patients: a nationwide population-based analysis

  • Urology - Original Paper
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Abstract

Purpose

To compare differences in clinical characteristics and outcomes between patients with and without human immunodeficiency virus (HIV) infection in light of robot-assisted laparoscopic radical prostatectomy (RALRP) as the most common surgical technique for prostate cancer. Previous data on perioperative complication rates of RALRP in HIV(+) patients are limited by small sample size.

Methods

The National Inpatient Sample database from 2008 to 2014 was used to query prostate cancer patients who underwent RALRP. HIV(+) patients were identified through ICD9 codes 042, 043, 044, V08 and 079.53. Intraoperative and postoperative complications, rate of blood transfusion, in-hospital mortality, prolonged length of stay and total cost were compared by univariate, multivariate regression and 1:4 propensity score matched analyses.

Results

Overall, 270,319 weighted patients undergoing RALRP were identified, among whom 546 (0.20%) patients were diagnosed with HIV. Patients with HIV were younger, less likely to be white and had more comorbidities. Multivariable regression analysis revealed that HIV(+) patients had significantly increased genitourinary complications (odds ratio [OR]: 3.31; 95% confidence interval [CI]: 1.03–10.68) and miscellaneous surgical events (OR 3.19; 95% CI 1.26–8.08). There were no differences in potentially life-threatening cardiac, respiratory and vascular events between patients with and without HIV after RALRP. Propensity score matched analysis yielded similar results.

Conclusions

Our findings suggest that patients who underwent RALRP with HIV did not experience higher risk of potentially life-threatening postoperative complications. RALRP could be safely considered as a surgical treatment for HIV(+) patients with prostate cancer.

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Funding

This study was supported by grants from the National key research and development program of China (No. 2017YFC0908005) and the Fourth Round of Shanghai Three-year Action Plan on Public Health Discipline and Talent Program: Evidence-based Public Health and Health Economics (No. 15GWZK0901).

Author information

Author notes

  1. Hedong Han, Chen Ye and Zhongjun Tang contributed equally to the study.

Authors and Affiliations

  1. Department of Health Statistics, Second Military Medical University, No. 800 Xiangyin Road, Shanghai, 200433, China

    Hedong Han, Yingyi Qin, Yiming Ruan & Jia He

  2. Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China

    Chen Ye

  3. Department of Ophthalmology, Minhang Hospital, Fudan University, Shanghai, China

    Zhongjun Tang

  4. Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, 701 82, Örebro, Sweden

    Yang Cao

  5. Tongji University School of Medicine, Shanghai, 200092, China

    Jia He

Authors
  1. Hedong Han
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  2. Chen Ye
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  4. Yingyi Qin
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Contributions

HH, CY and ZT designed the research. HH and YR had full access to the data. HH and CY conducted all analysis. HH and ZT wrote the draft of this paper. YQ, YR and YC revised the article critically. All the authors contributed to the manuscript writing, read and approved the final manuscript. JH was the guarantor.

Corresponding author

Correspondence to Jia He.

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Conflict of interest

The authors report no disclosures relevant to the manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent is not required due to the retrospective de-identified dataset from the National Inpatient Sample.

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Electronic supplementary material

Below is the link to the electronic supplementary material.

11255_2019_2321_MOESM1_ESM.eps

Supplementary material 1: Supplementary Fig. 1. Propensity score matching analysis of perioperative outcomes in RALRP patients (EPS 737 kb)

11255_2019_2321_MOESM2_ESM.docx

Supplementary material 2: Supplementary Table 1. Absolute standard differences for variables before and after propensity score matching (DOCX 13 kb)

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Han, H., Ye, C., Tang, Z. et al. Clinical characteristics and outcomes of robot-assisted laparoscopic radical prostatectomy in HIV-positive patients: a nationwide population-based analysis. Int Urol Nephrol 52, 481–487 (2020). https://doi.org/10.1007/s11255-019-02321-z

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  • DOI: https://doi.org/10.1007/s11255-019-02321-z

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