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HPV infection in urology practice

  • Urology - Review
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Abstract

Human papillomavirus (HPV) is the most common pathogen of sexually transmitted disease worldwide. While HPV is responsible for low-grade benign lesions in the anogenital area such as condyloma acuminatum, it is also strongly associated with cervical, anal, vulvar/vaginal, and penile carcinomas. In addition to being an oncogenic virus, HPV causes a substantial socioeconomic burden due to the recurrence of benign lesions, the lack of a definitive treatment option that provides a complete cure, and the high cost of treatment. The global incidence of HPV infection is rising, especially among young and sexually active individuals; as a result, in recent years these infections have also become increasingly conspicuous in urology practice, both as incidental findings and primary complaints. The aim of this review is to evaluate the pathogenesis, diagnosis, and treatment modalities of HPV infections in light of the current literature from the urologist’s perspective.

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Abbreviations

CA:

Condyloma acuminatum

CDC:

Centers for disease control and prevention

DNA:

Deoxyribonucleic acid

FDA:

Food and drug administration

HPV:

Human papilomavirus

PCR:

Polymerase chain reaction

RB:

Retinoblastoma

References

  1. Tolstov Y, Hadaschik B, Pahernik S, Hohenfellner M, Duensing S (2014) Human papillomaviruses in urological malignancies: a critical assessment. Urol Oncol 32(1):46.e19–46.e27. https://doi.org/10.1016/j.urolonc.2013.06.012

    Article  CAS  Google Scholar 

  2. Cobos C, Figueroa JA, Mirandola L et al (2014) The role of human papilloma virus (HPV) infection in non-anogenital cancer and the promise of immunotherapy: a review. Int Rev Immunol 33(5):383–401. https://doi.org/10.3109/08830185.2014.911857

    Article  CAS  PubMed  Google Scholar 

  3. Heidegger I, Borena W, Pichler R (2015) The role of human papilloma virus in urological malignancies. Anticancer Res 35(5):2513–2519. http://www.ncbi.nlm.nih.gov/pubmed/25964524. Accessed 30 Nov 2018

  4. Sarier M, Sepin N, Keles Y et al (2019) Is there any association between urothelial carcinoma of the bladder and human papillomavirus? A case-control study. Urol Int 2019:1–6. https://doi.org/10.1159/000500467

    Article  Google Scholar 

  5. Stanley M (2006) Immune responses to human papillomavirus. Vaccine 24:S16–S22. https://doi.org/10.1016/j.vaccine.2005.09.002

    Article  CAS  PubMed  Google Scholar 

  6. Avcı GA, Gülendam B (2013) Human papillomavirus. Kafkas J Med Sci 3(3):136–144. https://doi.org/10.5505/kmjs.2013.52724

    Article  Google Scholar 

  7. Garolla A, Pizzol D, Bertoldo A, De Toni L, Barzon L, Foresta C (2013) Association, prevalence, and clearance of human papillomavirus and antisperm antibodies in infected semen samples from infertile patients. Fertil Steril 99(1):125–131. https://doi.org/10.1016/J.FERTNSTERT.2012.09.006

    Article  PubMed  Google Scholar 

  8. Liu M, He Z, Zhang C et al (2014) Prevalence, incidence, clearance, and associated factors of genital human papillomavirus infection among men: a population-based cohort study in rural China. Cancer Epidemiol Biomarkers Prev 23(12):2857–2865. https://doi.org/10.1158/1055-9965.EPI-14-0365

    Article  CAS  PubMed  Google Scholar 

  9. Muñoz N, Méndez F, Posso H et al (2004) Incidence, duration, and determinants of cervical human papillomavirus infection in a cohort of colombian women with normal cytological results. J Infect Dis 190(12):2077–2087. https://doi.org/10.1086/425907

    Article  PubMed  Google Scholar 

  10. Muñoz N, Bosch FX, de Sanjosé S et al (2003) Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348(6):518–527. https://doi.org/10.1056/NEJMoa021641

    Article  PubMed  Google Scholar 

  11. Ma X, Wang Q, Ong JJ et al (2018) Prevalence of human papillomavirus by geographical regions, sexual orientation and HIV status in China: a systematic review and meta-analysis. Sex Transm Infect 94(6):434–442. https://doi.org/10.1136/sextrans-2017-053412

    Article  PubMed  Google Scholar 

  12. Stanley MA, Pett MR, Coleman N (2007) HPV: from infection to cancer. Biochem Soc Trans 35(6):1456–1460. https://doi.org/10.1042/BST0351456

    Article  CAS  PubMed  Google Scholar 

  13. Nielson CM, Harris RB, Nyitray AG, Dunne EF, Stone KM, Giuliano AR (2010) Consistent condom use is associated with lower prevalence of human papillomavirus infection in men. J Infect Dis 202(3):445–451. https://doi.org/10.1086/653708

    Article  PubMed  Google Scholar 

  14. Schneider A (1993) Pathogenesis of genital HPV infection. Genitourin Med 69(3):165–173. http://www.ncbi.nlm.nih.gov/pubmed/8392965. Accessed 15 Apr 2019

    Article  CAS  Google Scholar 

  15. Münger K (2002) The role of human papillomaviruses in human cancers. Front Biosci 7:d641–9. http://www.ncbi.nlm.nih.gov/pubmed/11861215. Accessed 15 Apr 2019

    Article  Google Scholar 

  16. Andersen ES, Thorup K, Larsen G (1988) The results of cryosurgery for cervical intraepithelial neoplasia. Gynecol Oncol 30(1):21–25. http://www.ncbi.nlm.nih.gov/pubmed/3366393. Accessed 15 Apr 2019

    Article  CAS  Google Scholar 

  17. Mayrand M-H, Duarte-Franco E, Rodrigues I et al (2007) Human papillomavirus DNA versus papanicolaou screening tests for cervical cancer. N Engl J Med 357(16):1579–1588. https://doi.org/10.1056/NEJMoa071430

    Article  CAS  PubMed  Google Scholar 

  18. Kösel S, Burggraf S, Mommsen J, Engelhardt W, Olgemöller B (2003) Type-specific detection of human papillomaviruses in a routine laboratory setting–improved sensitivity and specificity of PCR and sequence analysis compared to direct hybridisation. Clin Chem Lab Med 41(6):787–791. https://doi.org/10.1515/CCLM.2003.119

    Article  PubMed  Google Scholar 

  19. Cai T, Mazzoli S, Meacci F et al (2011) Human papillomavirus and non-muscle invasive urothelial bladder cancer: potential relationship from a pilot study. Oncol Rep 25(2):485–489. https://doi.org/10.3892/or.2010.1083

    Article  PubMed  Google Scholar 

  20. Nilyanimit P, Chansaenroj J, Srisomboon J et al (2018) Human papillomavirus in thai women and men with anogenital warts. Intervirology 61(5):223–229. https://doi.org/10.1159/000497351

    Article  CAS  PubMed  Google Scholar 

  21. Gall SA (2001) Female genital warts: global trends and treatments. Infect Dis Obstet Gynecol 9(3):149–154. https://doi.org/10.1155/S1064744901000278

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Kilciler M, Bedir S, Erdemir F et al (2007) Condylomata acuminata of external urethral meatus causing infravesical obstruction. Int Urol Nephrol 39(1):107–109. https://doi.org/10.1007/s11255-005-4986-3

    Article  PubMed  Google Scholar 

  23. Camenga DR, Dunne EF, Desai MM et al (2013) Incidence of genital warts in adolescents and young adults in an integrated health care delivery system in the United States before human papillomavirus vaccine recommendations. Sex Transm Dis 40(7):534–538. https://doi.org/10.1097/OLQ.0b013e3182953ce0

    Article  PubMed  Google Scholar 

  24. Sarier M, Ozel E, Duman I, Yuksel Y, Demirbas A (2017) HPV type 45-positive condyloma acuminata of the bladder in a renal transplant recipient. Transpl Infect Dis 19(2):e12667. https://doi.org/10.1111/tid.12667

    Article  Google Scholar 

  25. Giuliano AR, Lee JH, Fulp W et al (2011) Incidence and clearance of genital human papillomavirus infection in men (HIM): a cohort study. Lancet. https://doi.org/10.1016/S0140-6736(10)62342-2

    Article  PubMed  PubMed Central  Google Scholar 

  26. Assmann G, Sotlar K (2011) HPV-associated squamous cell carcinogenesis. Pathologe 32(5):391–398. https://doi.org/10.1007/s00292-011-1442-2

    Article  CAS  PubMed  Google Scholar 

  27. Giuliano AR, Tortolero-Luna G, Ferrer E et al (2008) Epidemiology of human papillomavirus infection in men, cancers other than cervical and benign conditions. Vaccine 26:K17–K28. https://doi.org/10.1016/j.vaccine.2008.06.021

    Article  PubMed  PubMed Central  Google Scholar 

  28. Marchionne E, Perez C, Hui A, Khachemoune A (2017) Penile squamous cell carcinoma: a review of the literature and case report treated with Mohs micrographic surgery. An Bras Dermatol 92(1):95–99. https://doi.org/10.1590/abd1806-4841.20175009

    Article  PubMed  PubMed Central  Google Scholar 

  29. Kraus I, Molden T, Holm R et al (2006) Presence of E6 and E7 mRNA from human papillomavirus types 16, 18, 31, 33, and 45 in the majority of cervical carcinomas. J Clin Microbiol 44(4):1310–1317. https://doi.org/10.1128/JCM.44.4.1310-1317.2006

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Longworth MS, Laimins LA (2004) Pathogenesis of human papillomaviruses in differentiating epithelia. Microbiol Mol Biol Rev 68(2):362–372. https://doi.org/10.1128/MMBR.68.2.362-372.2004

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Shaker OG, Hammam OA, Wishahi MM (2013) Is there a correlation between HPV and urinary bladder carcinoma? Biomed Pharmacother 67(3):183–191. https://doi.org/10.1016/j.biopha.2012.10.019

    Article  PubMed  Google Scholar 

  32. Gould VE, Schmitt M, Vinokurova S et al (2010) Human papillomavirus and p16 expression in inverted papillomas of the urinary bladder. Cancer Lett 292(2):171–175. https://doi.org/10.1016/j.canlet.2009.11.022

    Article  CAS  PubMed  Google Scholar 

  33. Gutiérrez J, Jiménez A, de Dios Luna J, Soto MJ, Sorlózano A (2006) Meta-analysis of studies analyzing the relationship between bladder cancer and infection by human papillomavirus. J Urol 176((6 Pt 1)):2474–2481. https://doi.org/10.1016/j.juro.2006.07.157(discussion 2481)

    Article  PubMed  Google Scholar 

  34. Mai S, Welzel G, Ottstadt M et al (2015) Prognostic relevance of HPV infection and p16 overexpression in squamous cell anal cancer. Int J Radiat Oncol Biol Phys 93(4):819–827. https://doi.org/10.1016/j.ijrobp.2015.08.004

    Article  CAS  PubMed  Google Scholar 

  35. Lopaschuk CC (2013) New approach to managing genital warts. Can Fam Physician 59(7):731-736. http://www.ncbi.nlm.nih.gov/pubmed/23851535. Accessed 7 May 2019

  36. Ockenfels HM (2016) Therapeutic management of cutaneous and genital warts. JDDG 14(9):892–899. https://doi.org/10.1111/ddg.12838

    Article  PubMed  Google Scholar 

  37. de Camargo CC, D’Elia MPB, Miot HA (2017) Quality of life in men diagnosed with anogenital warts. An Bras Dermatol 92(3):427–429. https://doi.org/10.1590/abd1806-4841.20175282

    Article  PubMed  PubMed Central  Google Scholar 

  38. Mistrangelo M, Dal Conte I, Volpatto S et al (2018) Current treatments for anal condylomata acuminata. Minerva Chir 73(1):100–106. https://doi.org/10.23736/S0026-4733.17.07554-X

    Article  PubMed  Google Scholar 

  39. Scheinfeld N (2013) Update on the treatment of genital warts. Dermatol Online J 20;19(6):18559. http://www.ncbi.nlm.nih.gov/pubmed/24011309. Accessed 7 May 2019

  40. Yanofsky VR, Patel R V, Goldenberg G (2012) Genital warts: a comprehensive review. J Clin Aesthet Dermatol 5(6):25–36. http://www.ncbi.nlm.nih.gov/pubmed/22768354. Accessed 7 May 2019

  41. Yuan J, Ni G, Wang T et al (2018) Genital warts treatment: beyond imiquimod. Hum Vaccin Immunother 14(7):1815–1819. https://doi.org/10.1080/21645515.2018.1445947

    Article  PubMed  PubMed Central  Google Scholar 

  42. Steben M, Garland SM (2014) Genital warts. Best Pract Res Clin Obstet Gynaecol 28(7):1063–1073. https://doi.org/10.1016/j.bpobgyn.2014.07.002

    Article  PubMed  Google Scholar 

  43. Yılmaz Ö, Okçelik S, Yeşildal C, Soydan H, Ateş FŞT (2017) Our surgical treatment results in urethral condylomata acuminata cases. New J Urol 12(1):36–39

    Google Scholar 

  44. Hancock G, Hellner K, Dorrell L (2018) Therapeutic HPV vaccines. Best Pract Res Clin Obstet Gynaecol 47:59–72. https://doi.org/10.1016/j.bpobgyn.2017.09.008

    Article  PubMed  Google Scholar 

  45. Gallagher KE, LaMontagne DS, Watson-Jones D (2018) Status of HPV vaccine introduction and barriers to country uptake. Vaccine 36((32 Pt A)):4761–4767 https://doi.org/10.1016/j.vaccine.2018.02.003

    Article  CAS  PubMed  Google Scholar 

  46. Meites E, Kempe A, Markowitz LE (2016) Use of a 2-dose schedule for human papillomavirus vaccination—updated recommendations of the advisory committee on immunization practices. MMWR 65(49):1405–1408. https://doi.org/10.15585/mmwr.mm6549a5

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Istinye University, Istanbul, Turkey

    Mehmet Sarier

  2. Department of Dermatology, Medical Park Hospital, Antalya, Turkey

    Ali Murat Ceyhan

  3. Department of Clinical Microbiology and Infectious Disease, Education and Research Hospital, Antalya, Turkey

    Nevgun Sepin

  4. Department of Pathology, Antalya Pathology Laboratories, Antalya, Turkey

    Esin Ozel

  5. Department of Obstetrics and Gynaecology, Memorial Hospital, Antalya, Turkey

    Mehmet Murat Inal

  6. Department of Urology, Medical Park Hospital, Muratpaşa, Antalya, Turkey

    Mehmet Sarier & Erdal Kukul

  7. Department of Urology, Gozde Academy Hospital, Malatya, Turkey

    Ahmet Soylu

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  1. Mehmet Sarier
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Correspondence to Mehmet Sarier.

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Sarier, M., Ceyhan, A.M., Sepin, N. et al. HPV infection in urology practice. Int Urol Nephrol 52, 1–8 (2020). https://doi.org/10.1007/s11255-019-02302-2

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