Abstract
Objectives
We aimed to evaluate the role of nephrin and podocalyxin in determining the intervals between shock wave lithotripsy (SWL) sessions and how soon the kidney damage was recovered.
Methods
This work was a prospective study that included 30 patients with unilateral kidney stones. The patients’ midflow urine samples were collected before SWL and 1 h, 1 day and 1 week after the procedure. Nephrin and podocalyxin levels in the urine samples were measured by the enzyme-linked immunosorbent assay method.
Results
Among the 30 patients who underwent SWL, 19 were males and 11 were females. The mean age of the SWL group was 34.7 ± 13.2. Both biomarkers did not correlate with age, creatinine values, body mass index, stone side, stone size, energy, frequency and shock numbers. Nephrin and podocalyxin levels were significantly higher at the pre-SWL point (p < 0.05). After the procedure, a significant decrease was observed in both biomarker levels (p < 0.05). At the end of first day, these levels started to increase progressively up to the end of the first week (p > 0.05).
Conclusions
Nephrin and podocalyxin may help to determine early period kidney damage associated with SWL. Post-SWL podocalyxin and nephrin values may be used to determine the interval between SWL sessions.
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Abbreviations
- BMI:
-
Body mass index
- SWL:
-
Shock wave lithotripsy
- SD:
-
Slit diaphragm
- HESW:
-
High-energy shock waves
- ERPF:
-
Effective renal plasma flow
- ROS:
-
Reactive oxygen species
- RIRS:
-
Retrograde intrarenal surgery
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KH: project development, data collection, data analysis, manuscript writing. BF: project development, data collection. AN: data collection, manuscript editing. Kİ: data collection, manuscript editing. ŞE: project development, data collection, data analysis, manuscript editing. SK: data analysis, manuscript editing.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study protocol (2018/01-01) was approved by the ethics committee of the Health Sciences University Erzurum Regional Education and Research Hospital.
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Kocatürk, H., Atasoy, N., Bedir, F. et al. Evaluation of the urinary podocalyxin and nephrin excretion levels to determine a safe time interval between two sessions of SWL for renal stones: a non randomized exploratory study. Int Urol Nephrol 51, 1727–1734 (2019). https://doi.org/10.1007/s11255-019-02229-8
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DOI: https://doi.org/10.1007/s11255-019-02229-8