Determining whether dexmedetomidine provides a reno-protective effect in patients receiving laparoscopic radical prostatectomy: a pilot study

  • Shan Wu
  • Hui Yao
  • Nan Cheng
  • Na Guo
  • Jiaxin Chen
  • Mian Ge
  • Jun CaiEmail author
Urology - Original Paper



This study aims to determine whether perioperative treatment with dexmedetomidine (DEX) during laparoscopic radical prostatectomy (LRP) can provide a reno-protective effect.


This pilot study enrolled 89 patients between 60 and 79 years old, who underwent LRP. These patients were randomly allocated into two groups: group D (n = 44) and group C (n = 45). For patients in group D, 1 µg/kg of DEX was intravenously administered within 10 min, followed by 0.5 µg/kg/h of DEX infusion during the operation. This was stopped at 30 min before the end of surgery. For patients in group C, saline was administered at the same doses. The primary outcome was the incidence of acute kidney injury (AKI), and secondary outcomes included other postoperative variables.


The incidence of AKI in group D and C was 4.5% and 13.3%, respectively (P > 0.05). Compared with group C, patients in group D had significantly lower urea nitrogen levels at 6 h after surgery, lower creatinine levels at 6 and 48 h after surgery, and significantly lower CysC levels at 48 h after surgery. A significant decrease in VAS scores for pain and postoperative nausea and vomiting (PONV) at the second and third day after surgery was observed in patients in group D when compared to patients in group C.


Intraoperative DEX does not reduce the incidence of AKI, but provides a potential reno-protective effect, and alleviates postoperative pain and PONV in patients undergoing LRP.


Acute kidney injury Dexmedetomidine Estimated glomerular filtration rate Laparoscopic radical prostatectomy 



The authors thank Doctor Qianqian Zhu for the guidance of the statistics analyses in this manuscript, and we also thank Medjaden Bioscience Limited for editing and proofreading our manuscript.

Author contributions

SW and HY contributed to this work equally. SW and HY: clinical data collection, writing up of the first draft of the paper and data analysis; NC, NG and JXC: clinical anaesthesia for the patients; MG and JC: study design.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Shan Wu
    • 1
  • Hui Yao
    • 1
    • 2
  • Nan Cheng
    • 1
  • Na Guo
    • 1
  • Jiaxin Chen
    • 1
    • 3
  • Mian Ge
    • 1
  • Jun Cai
    • 1
    Email author
  1. 1.Department of AnesthesiologyThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina
  2. 2.Department of AnesthesiologyGuangdong Second Provincial General HospitalGuangzhouChina
  3. 3.Department of AnesthesiologyThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenChina

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