Androgen deprivation therapy and the risk of tenosynovitis in prostate cancer patients



Androgen deprivation therapy (ADT) use in prostate cancer (PCa) patients has been reported to have an association with rheumatoid arthritis. We aimed to assess the impact of ADT on the subsequent risk of tenosynovitis.


Using data from the National Health Insurance Research Database of Taiwan between 2001 and 2013, 3309 patients with PCa were identified. Among them, 729 ADT patients comprised the study group with 729 matched non-ADT controls. We used a 1:1 propensity score matched analysis. The demographic characteristics and comorbidities of the patients were analyzed; Cox proportional hazards regression was used to calculate the hazard ratios (HR) for the risk of tenosynovitis.


There were 224 (15.3%) patients with newly diagnosed tenosynovitis. Compared with non-ADT patients, ADT patients had a lower risk of subsequent tenosynovitis with an adjusted HR of 0.38 [95% confidence interval (CI) 0.28–0.51; P < 0.001].


ADT use apparently did not increase the risk of tenosynovitis in patients with PCa. Further studies are warranted to assess the clinical significance.

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Fig. 1
Fig. 2



Confidence interval


Androgen deprivation therapy


Prostate cancer


Hazard ratio


National Health Insurance Research Database


National Health Insurance


Cerebral vascular accident


Rheumatoid arthritis


Prostate-specific antigen


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This study was supported by the Taoyuan General Hospital, Ministry of Health and Welfare (Grant No. PYT10801) and Cross-institute Research Committee, Buddhist Tzu Chi Medical Foundation (TCMMP105-09-03).

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Correspondence to Ren-Jun Hsu.

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Liu, JM., Liu, DW., Chuang, HC. et al. Androgen deprivation therapy and the risk of tenosynovitis in prostate cancer patients. Int Urol Nephrol 51, 1113–1119 (2019).

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  • Prostate cancer
  • Tenosynovitis
  • Androgen deprivation therapy