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Urothelial carcinoma of the upper urinary tract: preoperative pyuria is not correlated with bladder cancer recurrence and survival

  • Urology - Original Paper
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Abstract

Objective

To identify the impact of preoperative pyuria on the bladder cancer recurrence and survival of patients who were treated surgically for UTUC.

Patients and methods

Study included 319 consecutive patients who were treated with RNU for UTUC. Cox proportional hazard regression models were used to evaluate the association of preoperative pyuria with outcome.

Results

Eighty patients (25.1%) had pyuria. Preoperative pyuria was associated with sex (P = 0.01), tumor focality (P = 0.01), tumor size (P = 0.05), tumor stage (P = 0.01), lymph node metastasis (P = 0.01), lymphovascular invasion (P = 0.02), and chemotherapy (P = 0.04). A total of 102 patients recurred, with a median time to bladder recurrence of 24.2 months. Bladder cancer recurrence-free survival rates for these 319 patients at 1, 3, 5, 7, and 10 years were 84.6, 72.4, 69.0, 68.3, and 68.0%, respectively. Preoperative pyuria was not independently associated with bladder cancer recurrence (HR 1.15; p = 0.5). Preoperative pyuria was associated with OS (HR 1.57; p = 0.02) and CSS (HR 1.65; p = 0.02). However, preoperative pyuria was not independently associated with OS and CSS (HR 1.07; p = 0.79).

Conclusions

Preoperative pyuria is unable to predict outcomes in a single-centre series of consecutive patients who were treated with RNU.

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Acknowledgements

This work was supported by the Ministry for Science and Technology of the Republic of Serbia, through Contact No. 175042.

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Authors and Affiliations

  1. Clinic of Urology, Clinical Center of Serbia, Resavska 51, Belgrade, 11000, Serbia

    Bogomir Milojevic, Zoran Dzamic, Nebojsa Bojanic, Otas Durutovic, Aleksandar Janicic, Boris Kajmakovic & Uros Bumbasirevic

  2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia

    Bogomir Milojevic, Zoran Dzamic, Nebojsa Bojanic, Otas Durutovic, Aleksandar Janicic, Boris Kajmakovic, Isidora Grozdic Milojevic & Uros Bumbasirevic

  3. Center of Nuclear Medicine, Clinical Center of Serbia, Belgrade, Serbia

    Isidora Grozdic Milojevic

  4. Clinic for Digestive Surgery, Clinical Center of Serbia, Belgrade, Serbia

    Nikola Grubor

  5. Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

    Sandra Sipetic Grujicic

Authors
  1. Bogomir Milojevic
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  2. Zoran Dzamic
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  3. Nebojsa Bojanic
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  4. Otas Durutovic
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  5. Aleksandar Janicic
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  6. Boris Kajmakovic
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  7. Isidora Grozdic Milojevic
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  8. Uros Bumbasirevic
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  9. Nikola Grubor
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  10. Sandra Sipetic Grujicic
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Corresponding author

Correspondence to Bogomir Milojevic.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Milojevic, B., Dzamic, Z., Bojanic, N. et al. Urothelial carcinoma of the upper urinary tract: preoperative pyuria is not correlated with bladder cancer recurrence and survival. Int Urol Nephrol 51, 831–838 (2019). https://doi.org/10.1007/s11255-019-02133-1

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  • DOI: https://doi.org/10.1007/s11255-019-02133-1

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