Serum vitamin D level may be a novel potential risk factor for premature ejaculation: a comparative study



To compare serum level of vitamin D [25(OH)D] in patients with life-long premature ejaculation (LPE) versus healthy controls.


Healthy married potent males were recruited from February 2017 to January 2018. Group A included 40 patients suffering from LPE who were compared versus 40 healthy controls (Group B). Participants suffering from hormonal disorders, obesity, neurological, psychological, or chronic diseases or taking medications that may affect ejaculatory function, serum level of vitamin D, or the accuracy of intra-vaginal ejaculation latency time (IELT) were excluded. LPE was self-reported by the patients with subsequent feelings of frustration and measured by premature ejaculation diagnostic tool (PEDT) and IELT using stopwatch handled by their partners. 25(OH)D was measured by obtaining 2 ml of venous blood. Statistical analysis was performed using Student t, Mann–Whitney, Chi square tests, logistic regression analysis, and Spearman correlation.


Sixteen (20%) participants had vitamin D insufficiency/deficiency. All of them were in PE group. 25(OH)D correlated significantly with IELT (r2 = 0.349; p < 0.001) and PEDT (r2 = 0.425; p < 0.001). There was no statistically significant difference in age (p = 0.341), BMI (p = 1) or IIEF-5 (p = 0.408) in both groups. 25(OH)D was significantly lower in patients than controls (35.75 vs. 58.92 ng/ml, p < 0.001). ROC analysis revealed that the best cut-off value of 25(OH)D to detect patients suffering from LPE was 50.65 ng/ml with a sensitivity and specificity of 85% for both. 25(OH)D remained a significant risk factor for LPE in the logistic regression analysis (p < 0.001).


The current study showed that vitamin D has significant association with LPE and correlates significantly with IELT and PEDT.

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Correspondence to Mohammed Said ElSheemy.

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The authors declare that they have no conflict of interest. No Funding Source or industrial links and affiliations.

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All procedures performed were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the local ethical committee.

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Informed consent was obtained from all individual participants included in the study.

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Abd El aal, A.M., GamalEl Din, S.F., Rashed, L.A. et al. Serum vitamin D level may be a novel potential risk factor for premature ejaculation: a comparative study. Int Urol Nephrol 50, 1975–1980 (2018).

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  • Lifelong premature ejaculation
  • Serotonin
  • Serum vitamin D
  • Tryptophan hydroxylase
  • Vitamin D deficiency