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Nephrotoxicity of iodixanol versus iopamidol in patients undergoing peripheral angiography with or without endovascular therapy

  • Hong-liang Xiong
  • Meng Peng
  • Xiong-jing Jiang
  • Hui Dong
  • Wu-qiang Che
  • Yang Chen
  • Yu-bao Zou
  • Bo Xu
  • Yue-jin Yang
  • Run-lin Gao
Nephrology - Original Paper
  • 6 Downloads

Abstract

Purpose

To compare the nephrotoxic effects of iodixanol and iopamidol in patients undergoing peripheral angiography.

Methods

Patients scheduled for peripheral angiography were randomly assigned to the iodixanol group (n = 463) and iopamidol group (n = 458). The primary endpoint was the incidence of contrast associated acute kidney injury (CA-AKI), which was defined as an increase ≥ 25% or ≥ 44.2 µmol/l (0.5 mg/dl) in serum creatinine (SCr) from baseline within 72 h after receiving contrast media (CM). The secondary endpoints were the mean peak SCr increase within 72 h after receiving CM and major adverse renal events (SCr increased by two times after 30 days, the need for dialysis treatment, rehospitalization for acute renal failure, or kidney-related death) during hospitalization and within 30 day postdischarge.

Results

The incidence of CA-AKI did not differ significantly between the iodixanol group and iopamidol group (18.1% vs. 16.8%; p = 0.595). There was no significant difference in the mean peak SCr increase between the iodixanol group and iopamidol group (10.4 ± 13.0 vs. 10.6 ± 14.3 µmol/l, p = 0.919). There were four patients [1 (0.2%) patient in the iodixanol group and 1 (0.7%) patients in the iopamidol group, p = 0.609] with doubling of SCr; no other adverse renal events were observed.

Conclusions

Our data showed that the nephrotoxicity of iodixanol was comparable with that of iopamidol in patients undergoing peripheral angiography.

Keywords

Contrast medium Contrast associated acute kidney injury Peripheral angiography 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  • Hong-liang Xiong
    • 1
  • Meng Peng
    • 2
  • Xiong-jing Jiang
    • 1
  • Hui Dong
    • 1
  • Wu-qiang Che
    • 1
  • Yang Chen
    • 1
  • Yu-bao Zou
    • 1
  • Bo Xu
    • 1
  • Yue-jin Yang
    • 1
  • Run-lin Gao
    • 1
  1. 1.Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.Department of CardiologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

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