International Urology and Nephrology

, Volume 50, Issue 8, pp 1467–1476 | Cite as

A holistic approach to factors affecting depression in haemodialysis patients

  • Georgia Gerogianni
  • Anastasios Kouzoupis
  • Eirini Grapsa
Nephrology - Review


Depression in dialysis populations is affected by co-morbid diseases, such as cardiovascular disease, diabetes, and immune dysfunction, and it also includes high suicide risk and frequent hospitalizations. Depressive disorders have a close association with malnutrition and chronic inflammation, as well as with cognitive impairment. Impaired cognitive function may be manifested as low adherence to dialysis treatment, leading to malnutrition. Additionally, chronic pain and low quality of sleep lead to high rates of depressive symptoms in haemodialysis patients, while an untreated depression can cause sleep disturbances and increased mortality risk. Depression can also lead to sexual dysfunction and non-adherence, while unemployment can cause depressive disorders, due to patients’ feelings of being a financial burden on their family. The present review provides a holistic approach to the factors affecting depression in haemodialysis, offering significant knowledge to renal professionals.


Depression Haemodialysis Kidney failure Pain Sleep disorders Unemployment 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Georgia Gerogianni
    • 1
  • Anastasios Kouzoupis
    • 2
  • Eirini Grapsa
    • 3
  1. 1.Department of NursingUniversity of West AtticaAthensGreece
  2. 2.First Department of Psychiatry, ‘Eginition’ HospitalNational and Kapodistrian University of AthensAthensGreece
  3. 3.Department of Nephrology, ‘Aretaieio’ HospitalNational and Kapodistrian University of AthensAthensGreece

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