The association of serum angiogenic growth factors with renal structure and function in patients with adult autosomal dominant polycystic kidney disease
- 15 Downloads
Autosomal dominant polycystic kidney disease (ADPKD) is a common congenital chronic kidney disease (CKD). We report here the relationship of serum angiopoietin-1 (Ang-1), Ang-2, and vascular endothelial growth factor (VEGF) with total kidney volume (TKV), total cyst volume (TCV), and renal failure in adult ADPKD patients at various stages of CKD.
This cross-sectional study was conducted with 50 patients diagnosed with ADPKD and a control group of 45 age-matched healthy volunteers. In patient group, TKV and TCV were determined with upper abdominal magnetic resonance imaging, whereas in controls, TKV was determined with ultrasonography according to ellipsoid formula. Renal function was assessed with serum creatinine, estimated glomerular filtration rate (eGFR), and spot urinary protein/creatinine ratio (UPCR). Ang-1, Ang-2, and VEGF were measured using enzyme-linked immunosorbent assay.
Patients with ADPKD had significantly higher TKV (p < 0.001) and UPCR (p < 0.001), and lower eGFR (p ≤ 0.001) compared to the controls. Log10Ang-2 was found to be higher in ADPKD patients at all CKD stages. Multiple linear regression analysis showed that there was no association between log10Ang-1, log10Ang-2, or log10VEGF and creatinine, eGFR, UPCR, log10TKV (p > 0.05).
There was no association of serum angiogenic growth factors with TKV or renal failure in ADPKD patients. Increased serum Ang-2 observed in stages 1–2 CKD suggests that angiogenesis plays a role in the progression of early stage ADPKD, but not at later stages of the disease. This may be explained by possible cessation of angiogenesis in advanced stages of CKD due to the increased number of sclerotic glomeruli.
KeywordsAutosomal dominant polycystic kidney disease Angiopoietin Vascular endothelial growth factor Total kidney volume Renal failure
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 2.Somlo S, Chapman AB (2012) Autosomal dominant polycystic kidney disease. In: Coffman TM, Falk RJ, Molitoris BA, Neilson EG, Schrier RW (eds) Schrier’s diseases of the kidney, 9th edn. Lippincott Williams & Wilkins, Philadelphia, pp 519–563Google Scholar
- 4.Chapman AB, Guay-Woodford LM, Grantham JJ et al (2003) Consortium for radiologic imaging studies of polycystic kidney disease cohort. Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): the consortium for radiologic imaging studies of polycystic kidney disease (CRISP) cohort. Kidney Int 64:1035–1045CrossRefPubMedGoogle Scholar
- 35.Brenchley P (1996) VEGF/VPF: a modulator of microvascular function with potential roles in glomerular pathophysiology. J Nephrol 9:10–17Google Scholar