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Betel nut chewing and the risk of chronic kidney disease: evidence from a meta-analysis

International Urology and Nephrology volume 50, pages 1097–1104 (2018)Cite this article

Abstract

Purpose

To investigate and quantify the potential association between betel nut chewing and the risk of chronic kidney disease (CKD).

Methods

We searched five online databases including PubMed, EMBASE, ISI Web of Science, Wanfang and CNKI to identify observational studies that published prior to May, 1, 2017. The primary outcome was the association between betel nut chewing and CKD expressed as odds ratio (OR) and the corresponding 95% confidence interval (95%CI) after adjustment for other covariates. Meta-analysis was performed using RevMan 5.3 software; the leave-one-out sensitivity analysis was used to confirm the stability of drawn conclusion.

Results

Five studies comprising a total of 10,562 CKD patients and 34,038 subjects without CKD that analyzed the relationship between betel nut chewing and CKD were included in our study; all the included studies were performed in Taiwan. After the adjustment for covariates, the combined adjusted ORs showed that betel nut used had 1.44 times higher risk to develop CKD compared with non-chewers (OR 1.44, 95%CI 1.08–1.92).

Conclusions

Betel nut chewing could significantly increase the risk of CKD, indicating that betel nut chewing may exist as an independent risk factor for CKD. Further investigation should be warranted.

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Author information

Author notes

  1. Meng Wang and Si-yi Yu contributed equally to this work.

Affiliations

  1. Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou District, Wuhan, 430030, China

    Meng Wang & Ying Yao

  2. The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China

    Si-Yi Yu

  3. Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou District, Wuhan, 430030, China

    Zheng-tao Lv

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  1. Meng Wang
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  2. Si-Yi Yu
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Correspondence to Zheng-tao Lv or Ying Yao.

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Wang, M., Yu, SY., Lv, Zt. et al. Betel nut chewing and the risk of chronic kidney disease: evidence from a meta-analysis. Int Urol Nephrol 50, 1097–1104 (2018). https://doi.org/10.1007/s11255-018-1819-8

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  • DOI: https://doi.org/10.1007/s11255-018-1819-8

Keywords

  • Betel nut chewing
  • Chronic kidney disease
  • Meta-analysis
  • Epidemiology