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Evaluation of hyoscine N-butyl bromide efficacy on the prevention of catheter-related bladder discomfort after transurethral resection of prostate: a randomized, double-blind control trial

  • Urology - Original Paper
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Abstract

Background

Transurethral resection of prostate (TURP) is the most common treatment for benign prostatic hyperplasia (BPH). Urinary tract catheter is inserted post-operatively which results in catheter-related bladder discomfort (CRBD) in many patients. The purpose of this study was to assess the preventive effect of hyoscine N-butyl bromide on CRBD caused by a urinary tract catheter after TURP surgery in patients with BPH.

Methods

Twenty-four and twenty-six patients in the treatment and control groups were enrolled, respectively. At the end of the surgery, slow intravenous injection of 20 mg hyoscine N-butyl bromide was administered to the patients of treatment group. The severity of CRBD was followed up at five different time periods and up to 2 h after surgery.

Results

On arrival to PACU and after 30 min of injection, statistically significant less CRBD was seen in the treatment group comparing to the control group (P ≤ 0.05 and P ≤ 0.007). The total utilized meperidine dose during PACU stay and the time to discharge for the intervention group were significantly lower than those for the control group (P ≤ 0.0001) with no significant difference in adverse effects (P > 0.05).

Conclusions

Hyoscine N-butyl bromide could reduce the severity of CRBD related to TURP in patients with BPH and their need for analgesic consumption either. It shortened the length of stay in the recovery room. Regarding its availability and low cost, it can be an effective pain relief drug for CRBD discomfort related to TURP in BPH patients.

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Acknowledgements

The authors would like to deeply thank all the staff working in operation theatres and PACU’s of Nemazee, Faghihi and Ali-Asghar hospitals for their kind help to the conduct of this study. Financial support was exclusively provided by Shiraz University of Medical Sciences. This article is the result of a thesis written by P. Adibi MD submitted to the school of medicine in partial fulfilment of the requirements for the degree of specialty in anaesthesiology.

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Correspondence to Elham Asadpour.

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Funding

This study was also funded by a Grant No. 4904 from Vice-Chancellery of Research and Technology in Shiraz University of Medical Sciences, Shiraz, Iran.

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

IRCT No.: 2013071013934N1.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Sabetian, G., Zand, F., Asadpour, E. et al. Evaluation of hyoscine N-butyl bromide efficacy on the prevention of catheter-related bladder discomfort after transurethral resection of prostate: a randomized, double-blind control trial. Int Urol Nephrol 49, 1907–1913 (2017). https://doi.org/10.1007/s11255-017-1663-2

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  • DOI: https://doi.org/10.1007/s11255-017-1663-2

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