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Association of H. pylori infection with chronic kidney disease among Chinese adults

  • Nephrology - Original Paper
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Abstract

Background

Some studies have suggested that Helicobacter pylori (H. Pylori) infection was associated with insulin resistance and metabolic syndrome, which may increase the risk of chronic kidney disease (CKD). But there is no conclusive evidence regarding the association between H. Pylori infection and CKD. To help clarify this, we conducted the cross-sectional study to investigate the association of H. pylori infection with CKD among Chinese adults.

Methods

A total of 22,044 adults aged 48.6 ± 14.3 years were enrolled. H. pylori-specific immunoglobulin G antibody titers were measured by ELISA. CKD was defined as estimated glomerular filtration rate (eGFR) less than <60 ml/min/1.73 m2 or presence of proteinuria (urine protein ≥ 1+) assessed using a repeated dipstick method.

Results

Among all participants in this study, the prevalence of H. Pylori infection was 20.6%. As a categorical outcome, the prevalence of decreased eGFR in the H. Pylori infection group was higher than in the non-H. Pylori infection group (1.6 vs. 1.2%, P = 0.04), but the prevalence of proteinuria and the overall CKD were not significantly different between these two groups (1.7 vs. 1.6%, P = 0.65 and 3.0 vs. 2.7%, P = 0.2). After adjusted for age, sex, hypertension, diabetes, body mass index, uric acid, smoking, drinking, total cholesterol, triglycerides, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, the odds of decreased eGFR and proteinuria were not significantly different between the H. Pylori positive and negative subjects.

Conclusions

This study did not find an association between H. Pylori infection and CKD.

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Acknowledgements

The research for this study was supported by the Key Science and Technology Research Projects from the natural science foundation of Shandong province (2013GSF11818).

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Author notes

    Authors and Affiliations

    1. Department of Nephrology, Qianfoshan Hospital, Shandong University, No.16766, Jingshi Road, 250014, Jinan, People’s Republic of China

      Xianglei Kong, Hong Su & Dongmei Xu

    2. Medical College, Shandong University, No.44, Wenhua West Road, Jinan, China

      Dayu Xu

    3. Department of Nephrology, Zaozhuang Municipal Hospital, Longtou Road, No.41, Zaozhuang, China

      Feng Li

    4. Department of Health Examination Center, Qianfoshan Hospital, Shandong University, No.16766, Jingshi Road, Jinan, China

      Xiaojing Ma

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    1. Xianglei Kong
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    Correspondence to Dongmei Xu.

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    Xianglei Kong and Dayu Xu have equally contributed to this work.

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    Kong, X., Xu, D., Li, F. et al. Association of H. pylori infection with chronic kidney disease among Chinese adults. Int Urol Nephrol 49, 845–850 (2017). https://doi.org/10.1007/s11255-016-1498-2

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    • DOI: https://doi.org/10.1007/s11255-016-1498-2

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