Skip to main content

Advertisement

SpringerLink
Log in

Coronary risk score for mineral bone disease in chronic non-diabetic hemodialysis patients: results from a prospective pilot study

  • Nephrology - Original Paper
  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Introduction

Chronic kidney disease-mineral bone disorder enhances coronary artery impairment (often occult and difficult to diagnose) in hemodialysis (HD) patients. The aim of the study was to correlate biochemical and imagistic parameters of MBD with the degree of documented coronary artery disease (CAD) in non-diabetic HD patients, in order to obtain a MBD-coronary risk score as a screening algorithm.

Methods

A 3-year prospective study was conducted on 168 non-diabetic HD patients, evaluating MBD biochemical parameters along with pulse wave velocity (PWV) determination and valve/coronary calcification assessment; coronary angiography was performed in symptomatic patients. Correlations between noninvasive parameters and the degree of coronary obstruction were assessed using IBM SPSS Statistics 20 software, Chi-square test and the determination of odds ratio.

Results

Significant differences in serum calcium (p < 0.001), phosphates (p = 0.03), bicarbonate (p < 0.001), albumin and iPTH (p = 0.002), percentage of deviations from PWV normal values (p = 0.004), average doses of phosphate binders and vitamin D and the number of vascular/valve calcifications were noted between the study group (angina, n = 17) and control group (asymptomatic, n = 151). After applying MBD-coronary risk score in control group, coronary angiography was performed in high-score patients.

Conclusion

A noninvasive screening algorithm for early diagnosis of CAD in asymptomatic HD patients with altered MBD parameters is necessary. Applying MBD-coronary risk score might be an important step in the prevention of major coronary episodes by extending the indication for further investigations, early diagnosis and treatment management.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Cheung AK, Sarnak MJ, Yan G, Berkoben M, Heyka R, Kaufman A, Lewis J, Rocco M, Toto R, Windus D, Ornt D, Levey AS, HEMO Study Group (2004) Cardiac diseases in maintenance hemodialysis patients: results of the HEMO Study. Kidney Int 65(6):2380–2389

    Article  PubMed  Google Scholar 

  2. US Renal Data System (2011) USRDS 2011 Annual Data Report. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD

    Google Scholar 

  3. Herzog CA, Passman R (2016) Evaluation of sudden cardiac arrest and sudden cardiac death in dialysis patients. UpToDate http://www.uptodate.com/contents/evaluation-of-sudden-cardiac-arrest-and-sudden-cardiac-death-in-dialysis-patients.com. Accessed March 2016

  4. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY (2004) Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351(13):1296–1305

    Article  CAS  PubMed  Google Scholar 

  5. Foley RN, Parfrey PS, Sarnak MJ (1998) Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis 32(5 Suppl 3):S112–S119

    Article  CAS  PubMed  Google Scholar 

  6. Collins AJ, Foley RN, Chavers B, Gilbertson D, Herzog C, Johansen K, Kasiske B, Kutner N, Liu J, Stpeter W, Guo H, Gustafson S, Heubner B, Lamb K, Li S, Li S, Peng Y, Qiu Y, Roberts T, Skeans M, Snyder J, Solid C, Thompson B, Wang C, Weinhandl E, Zaun D, Arko C, Chen SC, Daniels F, Ebben J, Frazier E, Hanzlik C, Johnson R, Sheets D, Wang X, Forrest B, Constantini E, Everson S, Eggers P, Agodoa L (2012) United States Renal Data System 2011 Annual Data Report: atlas of chronic kidney disease end-stage renal disease in the United States. Am J Kidney Dis 59(1 Suppl 1):A7, e1–e420

    Google Scholar 

  7. Herzog CA, Ma JZ, Collins AJ (1998) Poor long-term survival after acute myocardial infarction among patients on long-term dialysis. N Engl J Med 339(12):799–805

    Article  CAS  PubMed  Google Scholar 

  8. Nakai S, Masakane I, Akiba T, Iseki K, Watanabe Y, Itami N, Kimata N, Shigematsu T, Shinoda T, Syoji T, Syoji T, Suzuki K, Tsuchida K, Nakamoto H, Hamano T, Marubayashi S, Morita O, Morozumi K, Yamagata K, Yamashita A, Wakai K, Wada A, Tsubakihara Y (2007) Overview of regular dialysis treatment in Japan (as of 31 December 2005). Ther Apher Dial 11(6):411–441

    Article  PubMed  Google Scholar 

  9. Takeda K, Harada A, Okuda S, Fujimi S, Oh Y, Hattori F, Motomura K, Hirakata H, Fujishima M (1997) Sudden death in chronic dialysis patients. Nephrol Dial Transplant 12(5):952–955

    Article  CAS  PubMed  Google Scholar 

  10. Vázquez E, Sánchez-Perales C, García-García F, García-Cortés MJ, Torres J, Borrego F, Salas D, Liébana A, Fernandez-Guerrero JC (2014) Sudden death in incident dialysis patients. Am J Nephrol 39(4):331–336

    Article  PubMed  Google Scholar 

  11. Nakano T, Ninomiya T, Sumiyoshi S, Fujii H, Doi Y, Hirakata H, Tsuruya K, Iida M, Kiyohara Y, Sueishi K (2010) Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: the Hisayama study. Am J Kidney Dis 55(1):21–30

    Article  PubMed  Google Scholar 

  12. McCullough PA, Soman S (2004) Cardiovascular calcification in patients with chronic renal failure. Are we on target with this risk factor? Kidney Int Suppl 90:S18–S24

    Article  CAS  Google Scholar 

  13. Fox CS, Larson MG, Keyers MJ, Clouse ME, Culleton B, O’Donnell CJ (2004) Kidney function is inversely associated with coronary artery calcification in men and women free of cardiovascular disease: the Framingham Heart Study. Kidney Int 66(5):2017–2021

    Article  PubMed  Google Scholar 

  14. Koukoulaki M, Papachristou E, Kalogeropoulou C, Papathanasiou M, Zampakis P, Vardoulaki M, Alexopoulos D, Goumenos DS (2012) Increased prevalence and severity of coronary artery calcification in patients with chronic kidney disease stage III and IV. Nephron Extra 2(1):192–204

    Article  PubMed  PubMed Central  Google Scholar 

  15. Baber U, de Lemos JA, Khera A, McGuire DK, Omland T, Toto RD, Hedayati SS (2008) Non-traditional risk factors predict coronary calcification in chronic kidney disease in a population-based cohort. Kidney Int 73(5):615–621

    Article  CAS  PubMed  Google Scholar 

  16. Checherita IA, Manda G, Hinescu ME, Peride I, Niculae A, Bilha S, Gramaticu A, Voroneanu L, Covic A (2016) New molecular insights in diabetic nephropathy. Int Urol Nephrol 48(3):373–387

    Article  CAS  PubMed  Google Scholar 

  17. Nakamura S, Ishibashi-Ueda H, Niizuma S, Yoshihara F, Horio T, Kawano Y (2009) Coronary calcification in patients with chronic kidney disease and coronary artery disease. Clin J Am Soc Nephrol 4(12):1892–1900

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. McCullough PA, Sandberg KR, Dumler F, Yanez JE (2004) Determinants of coronary vascular calcification in patients with chronic kidney disease and end-stage renal disease: a systemic review. J Nephrol 17(2):205–215

    PubMed  Google Scholar 

  19. McCullough PA, Agrawal V, Danielewicz E, Abela GS (2008) Accelerated atherosclerotic calcification and Monckeberg’s sclerosis: a continuum of advanced vascular pathology in chronic kidney disease. Clin J Am SocNephrol 3(6):1585–1598

    Article  CAS  Google Scholar 

  20. Amann K (2008) Media calcification and intima calcification are distinct entities in chronic kidney disease. Clin J Am SocNephrol 3(6):1599–1605

    Article  Google Scholar 

  21. Kumar S, Bogle R, Banerjee D (2014) Why do young people with chronic kidney disease die early? World J Nephrol 3(4):143–155

    Article  PubMed  PubMed Central  Google Scholar 

  22. Cheung AK, Henrich WL (2016) Risk factors and epidemiology of coronary heart disease in end-stage renal disease (dialysis). UpToDate http://www.uptodate.com/contents/risk-factors-and-epidemiology-of-coronary-heart-disease-in-end-stage-renal-disease-dialysis.com. Accessed February 2016

  23. Fraker TD Jr, Fihn SD, Gibbons RJ, Abrams J, Chatterjee K, Daley J, Deedwania PC, Douglas JS, Ferguson TB Jr, Fihn SD, Fraker TD Jr, Gardin JM, O’Rourke RA, Williams SV, Smith SC Jr, Jacobs AK, Adams CD, Anderson JL, Buller CE, Creager MA, Ettinger SM, Halperin JL, Hunt SA, Krumholz HM, Kushner FG, Lytle BW, Nishimura R, Page RL, Riegel B, Tarkington LG, Yancy CW, American College of Cardiology, American Heart Association, American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group (2007) 2007 chronic angina focused update of the ACC/AHA 2002 Guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group to develop the focused update of the 2002 Guidelines for the management of patients with chronic stable angina. Circulation 116(23):2762–2772

    Article  PubMed  Google Scholar 

  24. Onan B, Onan IS, Bakir I (2012) Left anterior descending coronary artery muscular bridge: lengthy and complete. Tex Heart Inst J 39(4):598–600

    PubMed  PubMed Central  Google Scholar 

  25. Afazali B, Goldsmith DJA (2014) Vascular calcification in chronic kidney disease. UpToDate http://www.uptodate.com/contents/vascular-calcification-in-chronic-kidney-disease.com. Accessed March 2016

  26. Román-García P, Rodríguez-García M, Cabezas-Rodríguez I, López-Ongil S, Díaz-López B, Cannata-Andía JB (2011) Vascular calcification in patients with chronic kidney disease: types, clinical impact and pathogenesis. Med Princ Pract 20(3):203–212

    Article  PubMed  Google Scholar 

  27. Shanahan CM, Crouthamel MH, Kapustin A, Giachelli CM (2011) Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Circ Res 109(6):697–711

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Checherita IA, Smarandache D, David C, Ciocalteu A, Ion DA, Lascar I (2012) Vascular calcifications in chronic kidney disease - clinical management. Rom J Morphol Embryol 53(1):7–13

    CAS  PubMed  Google Scholar 

  29. Lu KC, Wu CC, Yen JF, Liu WC (2014) Vascular calcification and renal bone disorders. ScientificWorldJournal 2014:637065

    PubMed  PubMed Central  Google Scholar 

  30. Checherita IA, Smarandache D, Radulescu D, Peride I, Bratu O, Ciocalteu A, Sebe I, Lascar I (2013) Calcific uremic arteriolopathy in hemodialyzed patients. Chirurgia (Bucur) 108(5):736–740

    CAS  Google Scholar 

  31. Johnson RC, Leopold JA, Loscalzo J (2006) Vascular calcification: pathobiological mechanisms and clinical implications. Circ Res 99(10):1044–1059

    Article  CAS  PubMed  Google Scholar 

  32. Mizobuchi M, Towler D, Slatopolsky E (2009) Vascular calcification: the killer of patients with chronic kidney disease. J Am Soc Nephrol 20(7):1453–1464

    Article  CAS  PubMed  Google Scholar 

  33. Block GA, Klassen PS, Lazarus JM, Ofsthun N, Lowrie EG, Chertow GM (2004) Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 15(8):2208–2218

    Article  CAS  PubMed  Google Scholar 

  34. Chang JF, Feng YF, Peng YS, Hsu SP, Pai MF, Chen HY, Wu HY, Yang JY (2014) Combined alkaline phosphatase and phosphorus levels as a predictor of mortality in maintenance hemodialysis patients. Medicine (Baltimore) 93(18):e106

    Article  CAS  Google Scholar 

  35. Goodman WG, Goldin J, Kuizon BD, Yoon C, Gales B, Sider D, Wang Y, Chung J, Emerick A, Greaser L, Elashoff RM, Salusky IB (2000) Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 342(20):1478–1483

    Article  CAS  PubMed  Google Scholar 

  36. Garland JS, Holden RM, Groome PA, Lam M, Nolan RL, Morton AR, Pickett W (2008) Prevalence and associations of coronary artery calcification in patients with stages 3 to 5 CKD without cardiovascular disease. Am J Kidney Dis 52(5):849–858

    Article  CAS  PubMed  Google Scholar 

  37. Palit S, Kendrick J (2014) Vascular calcification in chronic kidney disease: role of disordered mineral metabolism. Curr Pharm Des 20(37):5829–5833

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Ewence AE, Bootman M, Roderick HL, Skepper JN, McCarthy G, Epple M, Neumann M, Shanahan CM, Proudfoot D (2008) Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization. Circ Res 103:e28–e34

    Article  CAS  PubMed  Google Scholar 

  39. Larsson TE, Olauson H, Hagström E, Ingelsson E, Arnlöv J, Lind L, Sundström J (2010) Conjoint effects of serum calcium and phosphate on risk of total, cardiovascular, and noncardiovascular mortality in the community. Arterioscler Thromb Vasc Biol 30(2):333–339

    Article  CAS  PubMed  Google Scholar 

  40. Yamada K, Fujimoto S, Nishiura R, Komatsu H, Tatsumoto M, Sato Y, Hara S, Hisanaga S, Ochiai H, Nakao H, Eto T (2007) Risk factors of the progression of abdominal aortic calcification in patients on chronic haemodialysis. Nephrol Dial Transplant 22(7):2032–2037

    Article  PubMed  Google Scholar 

  41. West SL, Swan VJ, Jamal SA (2010) Effects of calcium on cardiovascular events in patients with kidney disease and in a healthy population. Clin J Am Soc Nephrol 5(Suppl 1):S41–S47

    Article  CAS  PubMed  Google Scholar 

  42. Bălăceanu A, Diaconu C, David C, Niculae A, Peride A, Aron G (2014) Vascular calcifications, major risk factor for cardiovascular events in chronic kidney disease: an update on the pathophysiological process. Mod Med 21(2):116–119

    Google Scholar 

  43. Shroff RC, McNair R, Skepper JN, Figg N, Schurgers LJ, Deanfield J, Rees L, Shanahan CM (2010) Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification. J Am Soc Nephrol 21(1):103–112

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Reynolds JL, Joannides AJ, Skepper JN, McNair R, Schurgers LJ, Proudfoot D, Jahnen-Dechent W, Weissberg PL, Shanahan CM (2004) Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol 15(11):2857–2867

    Article  CAS  PubMed  Google Scholar 

  45. Proudfoot D, Skepper JN, Hegyi L, Bennett MR, Shanahan CM, Weissberg PL (2000) Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies. Circ Res 87(11):1055–1062

    Article  CAS  PubMed  Google Scholar 

  46. Kalantar-Zadeh K, Kuwae N, Regidor DL, Kovesdy CP, Kilpatrick RD, Shinaberger CS, McAllister CJ, Budoff MJ, Salusky IB, Kopple JD (2006) Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients. Kidney Int 70(4):771–780

    Article  CAS  PubMed  Google Scholar 

  47. Kalantar-Zadeh K, Shah A, Duong U (2010) Kidney bone disease and mortality in CKD: revisiting the role of vitamin D, calcimimetics, alkaline phosphatase, and minerals. Kidney Int Suppl 117:S10–S21

    Article  CAS  Google Scholar 

  48. Covic A, Kothawala P, Bernal M, Robbins S, Chalian A, Goldsmith D (2009) Systematic review of the evidence underlying the association between mineral metabolism disturbances and risk of all-cause mortality, cardiovascular mortality and cardiovascular events in chronic kidney disease. Nephrol Dial Transplant 24(5):1506–1523

    Article  PubMed  Google Scholar 

  49. Pisoni RL, Gillespie BW, Dickinson DM, Chen K, Kutner MH, Wolfe RA (2004) The Dialysis Outcomes and Practice Patterns Study (DOPPS): design, data elements, and methodology. Am J Kidney Dis 44(5 Suppl 2):7–15

    Article  PubMed  Google Scholar 

  50. Tentori F, Blayney MJ, Albert JM, Gillespie BW, Kerr PG, Bommer J, Young EW, Akizawa T, Akiba T, Pisoni RL, Robinson BM, Port FK (2008) Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: The Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis 52(3):519–530

    Article  CAS  PubMed  Google Scholar 

  51. Young EW, Albert JM, Satayathum S, Goodkin DA, Pisoni RL, Akiba T, Akizawa T, Kurokawa K, Bommer J, Piera L, Port FK (2005) Predictors and consequences of altered mineral metabolism: The Dialysis Outcomes and Practice Patterns study. Kidney Int 67(3):1179–1187

    Article  CAS  PubMed  Google Scholar 

  52. Mancia G, Fagard R, Narkiewicz K, Redón J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM, Schmieder RE, Sirnes PA, Sleight P, Viigimaa M, Waeber B, Zannad F, Members Task Force (2013) 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 31(7):1281–1357

    Article  CAS  PubMed  Google Scholar 

  53. Jadhav UM, Kadam NN (2005) Non-invasive assessment of arterial stiffness by pulse-wave velocity correlates with endothelial dysfunction. Indian Heart J 57(3):226–232

    PubMed  Google Scholar 

  54. Safar ME, Henry O, Meaume S (2002) Aortic pulse wave velocity: an independent marker of cardiovascular risk. Am J Geriatr Cardiol 11(5):295–298

    Article  PubMed  Google Scholar 

  55. Blacher J, Asmar R, Djane S, London GM, Safar ME (1999) Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Hypertension 33(5):1111–1117

    Article  CAS  PubMed  Google Scholar 

  56. Nichols WW, O’Rourke MF (1990) Properties of the arterial wall. In: Nichols WW, O’Rourke MF, McDonald DA (eds) McDonald’s blood flow in arteries: theoretical, experimental and clinical principles, 3rd edn. Edward Arnold, London, pp 77–114

    Google Scholar 

  57. Lehmann ED, Gosling RG, Sönksen PH (1992) Arterial wall compliance in diabetes. Diabet Med 9(2):114–119

    Article  CAS  PubMed  Google Scholar 

  58. Wada T, Kodaira K, Fujishiro K, Maie K, Tsukiyama E, Fukumoto T, Uchida T, Yamazaki S (1994) Correlation of ultrasound-measured common carotid artery stiffness with pathological findings. Arterioscler Thromb Vasc Biol 14(3):479–482

    Article  CAS  Google Scholar 

  59. London GM, Marchais SJ, Safar ME, Genest AF, Guerin AP, Metivier F, Chedid K, London AM (1990) Aortic and large artery compliance in end-stage renal failure. Kidney Int 37(1):137–142

    Article  CAS  PubMed  Google Scholar 

  60. Shantouf R, Kovesdy CP, Kim Y, Ahmadi N, Luna A, Luna C, Rambod M, Nissenson AR, Budoff MJ, Kalantar-Zadeh K (2009) Association of serum alkaline phosphatase with coronary artery calcification in maintenance hemodialysis patients. Clin J Am Soc Nephrol 4(6):1106–1114

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Kaysen GA (2000) Malnutrition and the acute-phase reaction in dialysis patients - how to measure and how to distinguish. Nephrol Dial Transplant 15(10):1521–1524

    Article  CAS  PubMed  Google Scholar 

  62. Yamada S, Tokumoto M, Tatsumoto N, Tsuruya K, Kitazono T, Ooboshi H (2016) Very low protein diet enhances inflammation, malnutrition, and vascular calcification in uremic rats. Life Sci 146:117–123

    Article  CAS  PubMed  Google Scholar 

  63. Yamada S, Tokumoto M, Tatsumoto N, Taniguchi M, Noguchi H, Nakano T, Masutani K, Ooboshi H, Tsuruya K, Kitazono T (2014) Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia. Am J Physiol Renal Physiol 306(12):F1418–F1428

    Article  CAS  PubMed  Google Scholar 

  64. Nam HS, Lee SM, Jeong EG, Lee DY, Son YK, Kim SE, Chung SH, Cho YR, Park JS, Lee SW, Noh MH, An WS (2015) Vascular calcification on plain radiographs is related with the severity of lesions detected by coronary angiography in dialysis patients. Tohoku J Exp Med 235(2):135–144

    Article  CAS  PubMed  Google Scholar 

  65. Adragão T, Pires A, Birne R, Curto JD, Lucas C, Gonçalves M, Negrão AP (2009) A plain X-ray vascular calcification score is associated with arterial stiffness and mortality in dialysis patients. Nephrol Dial Transplant 24(3):997–1002

    Article  PubMed  Google Scholar 

  66. Moe SM, Chertow GM (2006) The case against calcium-based phosphate binders. Clin J Am Soc Nephrol 1(4):697–703

    Article  CAS  PubMed  Google Scholar 

  67. Ikizler TA, Cano NJ, Franch H, Fouque D, Himmelfarb J, Kalantar-Zadeh K, Kuhlmann MK, Stenvinkel P, TerWee P, Teta D, Wang AY, Wanner C, International Society of Renal Nutrition and Metabolism (2013) Prevention and treatment of protein energy wasting in chronic kidney disease patients: a consensus statement by the International Society of Renal Nutrition and Metabolism. Kidney Int 84(6):1096–1107

    Article  CAS  PubMed  Google Scholar 

  68. K/DOQI National Kidney Foundation (2000) Clinical practice guidelines for nutrition in chronic renal failure. Am J Kidney Dis 35(6 Suppl 2):S1–S140

    Google Scholar 

  69. Bommer J, Locatelli F, Satayathum S, Keen ML, Goodkin DA, Saito A, Akiba T, Port FK, Young EW (2004) Association of predialysis serum bicarbonate levels with risk of mortality and hospitalization in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis 44(4):661–671

    Article  PubMed  Google Scholar 

  70. Yonova D (2009) Vascular calcification and metabolic acidosis in end stage renal disease. Hippokratia 13(3):139–140

    CAS  PubMed  PubMed Central  Google Scholar 

  71. Mendoza FJ, Lopez I, Montes de Oca A, Perez J, Rodriguez M, Aguilera-Tejero E (2008) Metabolic acidosis inhibits soft tissue calcification in uremic rats. Kidney Int 73(4):407–414

    Article  CAS  PubMed  Google Scholar 

  72. Arnett T (2003) Regulation of bone cell function by acid-base balance. Proc Nutr Soc 62:511–520

    Article  CAS  PubMed  Google Scholar 

  73. Charytan D, Kuntz RE, Mauri L, DeFilippi C (2007) Distribution of coronary artery disease and relation to mortality in asymptomatic hemodialysis patients. Am J Kidney Dis 49(3):409–416

    Article  PubMed  Google Scholar 

  74. Ohtake T, Kobayashi S, Moriya H, Negishi K, Okamoto K, Maesato K, Saito S (2005) High prevalence of occult coronary artery stenosis in patients with chronic kidney disease at the initiation of renal replacement therapy: an angiographic examination. J Am Soc Nephrol 16(4):1141–1148

    Article  PubMed  Google Scholar 

  75. Hakeem A, Bhatti S, Chang SM (2014) Screening and risk stratification of coronary artery disease in end-stage renal disease. JACC Cardiovasc Imaging 7(7):715–728

    Article  PubMed  Google Scholar 

  76. Sosnov J, Lessard D, Goldberg RJ, Yarzebski J, Gore JM (2006) Differential symptoms of acute myocardial infarction in patients with kidney disease: a community-wide perspective. Am J Kidney Dis 47(3):378–384

    Article  PubMed  Google Scholar 

  77. Cai Q, Mukku VK, Ahmad M (2013) Coronary artery disease in patients with chronic kidney disease: a clinical update. Curr Cardiol Rev 9(4):331–339

    Article  PubMed  PubMed Central  Google Scholar 

  78. De Vriese AS, Vandecasteele SJ, Van den Bergh B, De Geeter FW (2012) Should we screen for coronary artery disease in asymptomatic chronic dialysis patients? Kidney Int 81(2):143–151

    Article  PubMed  Google Scholar 

  79. Schmidt A, Stefenelli T, Schuster E, Mayer G (2001) Informational contribution of noninvasive screening tests for coronary artery disease in patients on chronic renal replacement therapy. Am J Kidney Dis 37(1):56–63

    Article  CAS  PubMed  Google Scholar 

  80. Sedlis SP, Jurkovitz CT, Hartigan PM, Goldfarb DS, Lorin JD, Dada M, Maron DJ, Spertus JA, Mancini GB, Teo KK, O’Rourke RA, Boden WE, Weintraub WS, COURAGE Study Investigators (2009) Optimal medical therapy with or without percutaneous coronary intervention for patients with stable coronary artery disease and chronic kidney disease. Am J Cardiol 104(12):1647–1653

    Article  PubMed  Google Scholar 

  81. Avezum A, Makdisse M, Spencer FA, Gore JM, Fox KA, Montalescot G, Eagle KA, White K, Mehta RH, Knobel E, Collet JP, Investigators GRACE (2005) Impact of age on management and outcome of acute coronary syndrome: observations from the Global Registry of Acute Coronary Events (GRACE). Am Heart J 149(1):67–73

    Article  PubMed  Google Scholar 

  82. Pidgeon GB, Lynn KL, Bailey RR, Robson RA, Ikram H (1995) Coronary angiography prior to renal transplantation. Nephrology 1(1):59–64

    Article  Google Scholar 

  83. Gurm HS, Gore JM, Anderson FA Jr, Wyman A, Fox KAA, Steg PG, Eagle KA (2012) Comparison of acute coronary syndrome in patients receiving versus not receiving chronic dialysis (from the Global Registry of Acute Coronary Events [GRACE] Registry). Am J Cardiol 109(1):19–25

    Article  PubMed  Google Scholar 

  84. Erbel R, Budoff M (2012) Improvement of cardiovascular risk prediction using coronary imaging: subclinical atherosclerosis: the memory of lifetime risk factor exposure. Eur Heart J 33(10):1201–1213

    Article  PubMed  Google Scholar 

  85. Gowdak LHW, de Lima JJG (2011) Coronary angiography in patients with chronic kidney disease. In Kiraç SF (ed) Advances in the diagnosis of coronary atherosclerosis. InTech, http://www.intechopen.com/books/advances-in-the-diagnosis-of-coronary-atherosclerosis/coronary-angiography-in-patients-with-chronic-kidney-disease. Accessed March 2016

  86. Marwick TH, Steinmuller DR, Underwood DA, Hobbs RE, Go RT, Swift C, Braun WE (1990) Ineffectiveness of dipyridamole SPECT thallium imaging as a screening technique for coronary artery disease in patients with end-stage renal failure. Transplantation 49(1):100–103

    Article  CAS  PubMed  Google Scholar 

  87. Prati F, Regar E, Mintz GS, Arbustini E, Di Mario C, Jang IK, Akasaka T, Costa M, Guagliumi G, Grube E, Ozaki Y, Pinto F, Serruys PW, Expert’s OCT Review Document (2010) Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis. Eur Heart J 31(4):401–415

    Article  PubMed  Google Scholar 

  88. Voiculeţ C, David C, Dragomirescu RF, Zară OD, Tiron AT, Bălăceanu A, Aron G (2015) Tomografia prin coerență optică, metodă inovatoare de evaluare a microarhitecturii plăcilor de aterom la pacienţii dializați cronic. Med Intern 6:65–70

    Google Scholar 

  89. Patsalas S, Eleftheriadis T, Spaia S, Theodoroglou H, Panou E, Liakopoulos V, Antoniadi G, Passadakis P, Vayonas G, Kanakis E, Vargemezis V (2005) The value of computed tomography-derive d coronary artery calcification score in coronary artery disease detection in asymptomatic hemodialysis patients. Ren Fail 27(6):683–688

    Article  PubMed  Google Scholar 

  90. Patsalas S, Eleftheriadis T, Spaia S, Theodoroglou H, Antoniadi G, Liakopoulos V, Passadakis P, Vayonas G, Vargemezis V (2007) Thirty-month follow-up of coronary artery calcification in hemodialysis patients: different roles for inflammation and abnormal calcium-phosphorous metabolism? Ren Fail 29(5):623–629

    Article  CAS  PubMed  Google Scholar 

  91. Drüeke TB (2008) Arterial intima and media calcification: distinct entities with different pathogenesis or all the same? Clin J Am Soc Nephrol 3(6):1583–1584

    Article  PubMed  Google Scholar 

  92. Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group (2009) KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int Suppl 113:S1–S130

    Google Scholar 

Download references

Authors’ contribution

Authors whose names appear on the submission have contributed sufficiently to the scientific work and therefore share collective responsibility and accountability for the results. Consent to submit has been received explicitly from all co-authors, as well as from the responsible authorities at the institute where the work has been carried out, before the submission.

Author information

Authors and Affiliations

  1. Department of Nephrology and Dialysis, “St. John” Emergency Clinical Hospital Bucharest, 37th Dionisie Lupu StreetSector 2, 020021, Bucharest, Romania

    Cristiana David, Ileana Peride, Andrei Niculae & Ionel Alexandru Checherita

  2. Clinical Department No. 3, “Carol Davila” University of Medicine and Pharmacy Bucharest, Bucharest, Romania

    Cristiana David, Ileana Peride, Andrei Niculae & Ionel Alexandru Checherita

  3. Department of Nephrology, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain

    Jordi Bover

  4. Department of Internal Medicine, “St. John” Emergency Clinical Hospital Bucharest, Bucharest, Romania

    Cornelia Voiculet

  5. Clinical Department No. 1, “Carol Davila” University of Medicine and Pharmacy Bucharest, Bucharest, Romania

    Cornelia Voiculet

  6. Department of Biostatistics and Biophysics, Faculty of Dental Medicine, “Ovidius” University Constanta, Constanta, Romania

    Lucian Cristian Petcu

  7. Department of Nephrology, “Dr. C. I. Parhon” Clinical Hospital Iasi, Iasi, Romania

    Adrian Covic

  8. Department of Internal Medicine I, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Iasi, Romania

    Adrian Covic

Authors
  1. Cristiana David
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jordi Bover
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Cornelia Voiculet
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ileana Peride
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lucian Cristian Petcu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Andrei Niculae
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Adrian Covic
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Ionel Alexandru Checherita
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Andrei Niculae.

Ethics declarations

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study protocol was approved by the Ethics Committee of our hospital (No. 25151/18.03.2013).

Informed consent

Verbal informed consent was obtained from all individual participants included in the study, and written informed consent was obtained from all patients that performed coronary angiography.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

David, C., Bover, J., Voiculet, C. et al. Coronary risk score for mineral bone disease in chronic non-diabetic hemodialysis patients: results from a prospective pilot study. Int Urol Nephrol 49, 689–700 (2017). https://doi.org/10.1007/s11255-016-1481-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11255-016-1481-y

Keywords

Search

Navigation