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The application of wrapping ureter by a pedicled gastrocolic omentum flap combined with an artificial external scaffold to prevent stoma stenosis in rabbit after ureterocutaneostomy

  • Urology - Original Paper
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Abstract

Objective

To evaluate the feasibility and possibility of wrapping ureter by a pedicled gastrocolic omentum flap combined with an artificial ureter external scaffold to prevent stoma stenosis in rabbit after ureterocutaneostomy.

Methods

Forty male New Zealand rabbits were involved in this study. For application of ureterocutaneostomy, the right ureter was wrapped by a pedicled gastrocolic omentum flap and combined with application of an artificial external scaffold, which served as experimental side. Traditional ureterocutaneostomy was applied in left ureter (control side). All rabbits were killed after 1 month, and the kidney, ureter and abdominal segment ureter were collected to study the morphological and pathological changes by using HE staining, Masson staining, immunohistochemistry staining and microvessel density (MVD) study.

Results

HE staining showed that renal medullary tubular dilatation, large number of collagen deposition, renal glomerular and renal tubular atrophy. Glomerular vascular leaves and interstitial fibrosis were detected in the kidney of control side. However, these abnormities in the kidney of experimental side were significantly alleviated compared to control side. The hydronephrosis and ureterectasia in the experimental side were dramatically attenuated compared to control side. Fibrosis in ureter around stoma and stoma stenosis were prevented by wrapping ureter by a pedicled gastrocolic omentum flap combined with an artificial external scaffold.

Conclusion

In this study, we have demonstrated that wrapping ureter by a pedicled gastrocolic omentum flap combined with an artificial external scaffold is capable of preventing stoma stenosis in rabbit after ureterocutaneostomy, which provided a new method and theoretical basis for clinical application in the future.

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Acknowledgements

This work was supported by grant from National Natural Science Foundation of China (No. 81300475 to Jiaming Wen).

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Authors and Affiliations

  1. Department of Urology, Second Affiliated Hospital, School of Medicine, Zhejiang University, 88# Jiefang Road, Hangzhou, 310009, Zhejiang, China

    Shigeng Zhang, Fei Gao, Chong Xue, Nan Zhang, Feng Gao, Shaojiang Li & Jiaming Wen

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  1. Shigeng Zhang
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  2. Fei Gao
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Correspondence to Jiaming Wen.

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The authors declare no conflict of interest.

Ethical approval

All rabbits were maintained and housed in accordance with NIH guidelines and with the approval of the Animal Care and Use Committee at the Second Affiliated Hospital of Zhejiang University.

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Zhang, S., Gao, F., Xue, C. et al. The application of wrapping ureter by a pedicled gastrocolic omentum flap combined with an artificial external scaffold to prevent stoma stenosis in rabbit after ureterocutaneostomy. Int Urol Nephrol 49, 255–261 (2017). https://doi.org/10.1007/s11255-016-1475-9

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  • DOI: https://doi.org/10.1007/s11255-016-1475-9

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