Effect of acupuncture on clinical symptoms and laboratory indicators for chronic prostatitis/chronic pelvic pain syndrome: a systematic review and meta-analysis
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To systematically review the efficacy and safety of acupuncture for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
PubMed, Cochrane library Central, Web of Science, Wang-fang Database, and CNKI were searched from their inception to June 30, 2016. Data of acupuncture for CP/CPPS following randomized controlled trials (RCTs) was included. The data were analyzed using the Cochrane Collaboration Review Manager. The primary data were the National Institute of Health-Chronic Prostatitis Index (NIH-CPSI) score at the end of follow-up.
Ten RCTs were enrolled. Acupuncture was superior to the control in NIH-CPSI (MD −3.98, [95 % CI −5.78 to −2.19]; P < 0.0001) and response rate (RR 4.12, [95 % CI 1.67–10.18]; P = 0.002). Acupuncture was superior to sham acupuncture on NIH-CPSI, response rate, pain, urinary, and quality of life (QOL). Standard medication was inferior to acupuncture in terms of NIH-CPSI (MD −3.08, [95 % CI −5.57 to −0.60]; P = 0.02) and response rate (RR 2.03, [95 % CI 1.04–3.97]; P = 0.04), but standard medication was superior to acupuncture on improving urinary symptoms. There was no significant difference in the adverse events. Acupuncture/acupuncture plus standard medication significantly down-regulated IL-1β compared with standard medication in prostatic fluid.
Acupuncture treating CP/CPPS is effective and safe. The effects of acupuncture on NIH-CPSI, response rate, pain symptoms, and QOF were superior to the control, but standard medication significantly improved urinary symptoms compared with acupuncture. Acupuncture can decrease the IL-1β in prostatic fluid for CP/CPPS.
KeywordsAcupuncture Chronic prostatitis Chronic pelvic pain syndrome Meta-analysis Review
This work was supported by Guangdong Provincial Science and technology Foundation of China (Grant No. 2010B031600268).
BP Liu, YT Wang, and SD Chen contributed equally to this study; BP Liu contributed to study design, data analysis and interpretation, manuscript drafting and revision, and statistical analysis support; YT Wang contributed to literature search, data acquisition and analysis, and manuscript drafting; SD Chen contributed to data acquisition, methodology assessment of included studies, interpretation, and statistical analysis.
Compliance with ethical standards
Conflict of interest
The authors have declared that no conflict of interests exists.
The present study is a meta-analysis of pooled data and systemic review of published data, the authors did not apply for ethics review committee.
- 9.Blanchet KD (2012) Acupuncture: gaining acceptance in urology: proves effective for a number of chronic conditions. BJU Int 109:ii–vGoogle Scholar
- 14.Ma Y, Sun ZX, Men B et al (2014) Efficacy observation on chronic pelvic pain syndrome of damp-heat stagnation pattern treated with acupoint catgut embedding therapy (Chinese). Chin Acupunct Moxib 34:351–355Google Scholar
- 15.Lee SW, Liong ML, Yuen KH et al (2008) Acupuncture versus sham acupuncture for chronic prostatitis/chronic pelvic pain. Am J Med 121(79):E1–E7Google Scholar
- 21.Qi XL, Pan FT, Wu WZ (2012) Effect of acupuncture on cytokine in patients with chronic nonbacterial prostatitis (Chinese). Shandong J Tradit Chin Med 31:418–420Google Scholar
- 22.Zhao JY, Song CS (2014) Clinical observation of Jiao Xue acupuncture treatment on IIIB prostatitis (Chinese). Chin J Hum Sex 23:57–59Google Scholar
- 23.Li SL, Tang L, Ye HX (2015) Clinical study of “Qing Zhuo Qu Du” Pills combined acupuncture for chronic non-bacterial prostatitis (Chinese). J Guangzhou Univ Tradit Chin Med 06:1035–1039 + 1046Google Scholar
- 24.Ma Y, Li XY, Li FQ et al (2015) Clinical study of catgut embedding treatment of male chronic pelvic pain syndrome (Chinese). Chin Acupunct Moxib 06:561–566Google Scholar
- 27.Chang S et al (2016) The efficacy of acupuncture in managing patients with chronic prostatitis/chronic pelvic pain syndrome: a systemic review and meta-analysis. Neurourol Urodyn. doi: 10.1002/nau.22958