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Is steroids therapy effective in treating phimosis? A meta-analysis

  • Urology - Review
  • Published:
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Abstract

Purpose

We evaluated a systematic review on the therapeutic efficacy of topical steroids in children with phimosis to provide data for the clinical options of pediatric phimosis.

Methods

We searched the related original studies on topical steroid therapy in pediatric phimosis before August 2014. Two reviewers independently performed the study selection, data extraction, risk of bias and reporting quality assessment with confirmation by cross-checking. The quality of eligible studies was appraised with the ‘Cochrane handbook.’ The meta-analysis was performed by REVMAN 5.2 software.

Results

Eleven studies were included with 1669 patients among which 1093 received topical steroids and 576 cases treated with placebo or only manual reduction. Significant difference of the treatment efficacy was detected among the three methods [OR 7.46, 95 % CI (4.42, 12.58), p < 0.00001]. In subgroup analysis, significant difference of the treatment efficacy was also detected whether with placebo or manual reduction only [respectively, OR 5.04, 95 % CI (3.19, 7.95), p < 0.00001; OR 16.28, 95 % CI (6.06, 43.69), p < 0.00001].

Conclusions

Compared to the placebo or manual reduction method, the topical steroid therapy is more effective in the treatment of phimosis in children. Although there is still controversy in the different type and dosage of steroid, this could be used against phimosis before circumcision.

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Author contributions

JML, JY and YTC drafted the manuscript. YTC, SHC, CX and TD performed the study selection, data extraction, risk of bias and reporting quality assessment. YTC performed the statistical work. All authors have read and approved the final manuscript.

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Correspondence to Jin Yang.

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Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Jiaming Liu, Jin Yang and Yuntian Chen have contributed equally to the work.

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Liu, J., Yang, J., Chen, Y. et al. Is steroids therapy effective in treating phimosis? A meta-analysis. Int Urol Nephrol 48, 335–342 (2016). https://doi.org/10.1007/s11255-015-1184-9

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  • DOI: https://doi.org/10.1007/s11255-015-1184-9

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